75 research outputs found
Performance monitoring in service-based computing
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Anti-inflamatĂłrio choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters
The impact on in vivo efficacy and safety of two novel ionic liquids based on the association of choline with nonsteroidal
anti-inflammatory drugs, ketoprofen and naproxen forming IL-APIs, was evaluated. Their lipophilicity,
solubility and toxicity were assessed aiming the illustration of the pharmaceutical profile and potential toxic
impact.
Partition coefficientwas determined usingmicelles of hexadecylphosphocholine and UV–Vis derivative spectroscopy.
Additionally, solubility in phosphate buffer pH 7.4 wasmeasured using amodified shake flaskmethod and
UV–Vis spectroscopy as detection technique. Ultimately, toxicity was considered resorting to a fully automated
cytochrome c oxidase assay based onmicrofluidics. The obtained results demonstrated that the IL-APIs' drug format
has the ability to interact with biological membranes and also improves solubility up to 58 times. Moreover,
it was evidenced that, although being a nutrient, choline influences the IL-APIs' toxicity. The studied anti-inflammatory
IL-APIs exhibited promising properties regarding their incorporation in pharmaceutical formulations
Topically Applied Minoxidil in Baldness
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65198/1/j.1365-4362.1985.tb05381.x.pd
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