13 research outputs found

    Dental caries and dental fluorosis in 7-12-year-old schoolchildren in Catalão, Goiás, Brazil Cárie e fluorose dentária em escolares de 7 a 12 anos de idade em Catalão, Goiás, Brasil

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    INTRODUCTION: Over the last two decades, the prevalence of dental caries in children has decreased and the prevalence of dental fluorosis has increased. Knowledge on the epidemiologic conditions of a population is fundamental for the planning of health programs. OBJECTIVES: To determine the prevalence of dental caries and dental fluorosis among schoolchildren, in Catalão, Goiás, Brazil. METHODS: A random sample of 432 schoolchildren aged 7-12-years old was obtained. WHO (1997) criteria for dental caries and fluorosis diagnosis were used. RESULTS: The DMFT indexes were 0.97; 1.20; 1.80; 1.62; 2.40 and 2.51 for 7, 8, 9, 10, 11 and 12 years old, respectively. Analysis of dental fluorosis for the same ages presented higher prevalence at 12 years old and for the female gender. The percentage of questionable dental fluorosis (Dean's classification) was 34.0%. Only 3% of the sample presented dental fluorosis with scores very mild, mild and moderate. CONCLUSIONS: The prevalence of caries in schoolchildren of Catalão, Goiás, Brazil, was low. In average, private schools showed better results than public schools; however, all schools presented a low DMFT index. In this study, dental fluorosis is not a public health problem and has not damaged dental esthetics.<br>INTRODUÇÃO: Nas últimas duas décadas, a prevalência de cárie dentária tem diminuído e a prevalência de fluorose dentária tem aumentado. Para se planejar programas de saúde é fundamental conhecer o perfil epidemiológico das populações. OBJETIVOS: Determinar a prevalência de cárie dentária e fluorose dentária em escolares do município de Catalão, Goiás, Brasil. MÉTODOS: A amostra randomizada foi composta por 432 escolares de 7 a 12 anos de idade. Os critérios utilizados para determinar a prevalência de cárie dentária e fluorose seguiram a metodologia proposta pela OMS, 1997. RESULTADOS: Os valores do Índice CPOD foram de 0,97; 1,20; 1,80; 1,62; 2,40 e 2,51 para as idades de 7, 8, 9, 10, 11 e 12 anos, respectivamente. Considerando o diagnóstico de fluorose dentária para as mesmas idades, houve maior prevalência nos estudantes de 12 anos de idade e no gênero feminino. A porcentagem de fluorose dentária questionável (classificação de Dean) foi de 34,0%. Somente 3,0% da amostra total, apresentou fluorose dentária nos escores muito leve, leve e moderado. CONCLUSÕES: A prevalência de cárie dentária em escolares de Catalão, Goiás, Brasil foi baixa. As escolas particulares mostraram melhores resultados que as escolas públicas, entretanto, em todas elas se verificou baixos valores do Índice CPOD. Neste estudo, a fluorose dentária não tem causado problemas à estética dental e não se caracterizou em um problema de Saúde Pública

    Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

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    Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike other systemic autoimmune diseases, in AS, the innate immune system has a dominant role characterized by aberrant activity of innate and innate-like immune cells, including γδ T cells, group 3 innate lymphoid cells, neutrophils, mucosal-associated invariant T cells and mast cells, at sites predisposed to the disease. The intestine is involved in disease manifestations, as it is at the forefront of the interaction between the mucosal-associated immune cells and the intestinal microbiota. Similarly, biomechanical factors, such as entheseal micro-trauma, might also be involved in the pathogenesis of the articular manifestation of AS, and sentinel immune cells located in the entheses could provide links between local damage, genetic predisposition and the development of chronic inflammation. Although these elements might support the autoinflammatory nature of AS, studies demonstrating the presence of autoantibodies (such as anti-CD74, anti-sclerostin and anti-noggin antibodies) and evidence of activation and clonal expansion of T cell populations support an autoimmune component to the disease. This Review presents the evidence for autoinflammation and the evidence for autoimmunity in AS and, by discussing the pathophysiological factors associated with each, aims to reconcile the two hypotheses.</p

    Pathogenesis of Brain Dysfunction in Inborn Errors of Amino Acid Metabolism

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    Microsomal Oxidation and Insecticide Metabolism

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