The Family Gives Thanks

It is good for families to have a special holiday set aside for expressing thanks to Almighty God for national and personal blessings. Of course this is no substitute for daily thankfulness, but it is a way of reminding us impressively of the importance of being thankful. A spirit of true thankfulness is one of the marks of wholesome family life

The Iowa Homemaker vol.35, no.12

The Family Gives Thanks, Dr. E. W. Remley, page 5 Better Planning For Better Living, Margot Copeland, page 6 To Win, Decorate Your Room!, page 8 “Sweater Dress-Up”, Sue Mullins, page 10 Introducing: Rose Liu From Formosa, Margot Copeland, page 11 Dr. P. Mabel Nelson, Amy Millen, page 12 Extra Dollars For You, Marilyn Ogland, page 14 Connaisseur De La Cuisine, Martha Burleigh and Martha Elder, page 15 Trends To A New Figure, Anne Beem, page 16 Glasses… For Modern Lasses, Donna Schneider, page 17 What’s New, Pat McBride, page 1

Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes

Doxorubicin (Dox) is an anthracycline used to effectively treat several forms of cancer. Unfortunately, the use of Dox is limited due to its association with cardiovascular complications which are manifested as acute and chronic cardiotoxicity. The pathophysiological mechanism of Dox induced cardiotoxicity appears to involve increased expression of the tumor suppressor protein p53 in cardiomyocytes, followed by cellular apoptosis. It is not known whether downregulation of p53 expression in cardiomyocytes would result in decreased rates of myocardial fibrosis which occurs in response to cardiomyocyte loss. Further, it is not known whether Dox can induce perivascular necrosis and associated fibrosis in the heart. In this study we measured the effects of acute Dox treatment on myocardial and perivascular apoptosis and fibrosis in a conditional knockout (CKO) mouse model system which harbours inactive p53 alleles specifically in cardiomyocytes. CKO mice treated with a single dose of Dox (20 mg/kg), did not display lower levels of myocardial apoptosis or reactive oxygen and nitrogen species (ROS/RNS) compared to control mice with intact p53 alleles. Interestingly, CKO mice also displayed higher levels of interstitial and perivascular fibrosis compared to controls 3 or 7 days after Dox treatment. Additionally, the decrease in levels of the microtubule protein α-tubulin, which occurs in response to Dox treatment, was not prevented in CKO mice. Overall, these results indicate that selective loss of p53 in cardiomyocytes is not sufficient to prevent Dox induced myocardial ROS/RNS generation, apoptosis, interstitial fibrosis and perivascular fibrosis. Further, these results support a role for p53 independent apoptotic pathways leading to Dox induced myocardial damage and highlight the importance of vascular lesions in Dox induced cardiotoxicity

EXPERIMENTAL STUDIES ON THE KINETIC BEHAVIOR OF WATER BOILER TYPE REACTORS

The KEWB Program is devoted to the study of the dynamic behavior of homogeneous type research reactors. The objectives of this program include studies to develop better and more complete understanding of phenomena which contribute to the kinetic behavior and the inherent safety of the water boiler reactor. The approach to the objectives has heen to construct a prototype 50 kw homogeneous reactor with the necessary auxiliary apparatus and to study the transient behavior of the system as a function of the more significant parameters which affect this behavior. These include the amount of reactivity release, rate of reactivity release, initial core pressure, initial core temperature, initial reactor power, and void volume above the core. Data are plotted. (auth

Program review of the water boiler reactor kinetic experiments /

"NAA-SR-1525 ; Physics.""Contract AT-11-1-GEN-8 ; Issue date: March 15, 1956."Includes bibliographical references (page 85).U.S. Atomic Energy Commission Contract ;Mode of access: Internet

The kinetic behavior of water boiler type reactors /

"NAA-SR-1618 ; Physics.""Contract AT-11-1-GEN-8 ; Issue date: April 1, 1956."Includes bibliographical references (page 32).U.S. Atomic Energy Commission Contract ;Mode of access: Internet