Ongoing Mass Transfer in the Interacting Galaxy Pair NGC 1409/10

I present two-band HST STIS imaging, and WIYN spectral mapping, of ongoing mass transfer in the interacting galaxy pair NGC 1409/10 (where NGC 1410 is the Seyfert galaxy also catalogued as III Zw 55). Archival snapshot WFPC2 imaging from the survey by Malkan et al. showed a dust feature stretching between the galaxies, apparently being captured by NGC 1409. The new images allow estimates of the mass being transferred and rate of transfer. An absorption lane typically 0.25" (100 pc) wide with a representative optical depth tau_B = 0.2 cuts across the spiral structure of NGC 1410, crosses the 7-kpc projected space between the nuclei, wraps in front of and, at the limits of detection, behind NGC 1409, and becomes a denser (tau_B = 0.4) polar feature around the core of NGC 1409. Combination of extinction data in two passbands allows a crude three-dimensional recovery of the dust structure, supporting the front/back geometry derived from colors and extinction estimates. The whole feature contains of order $10^6$ solar masses in dust, implying about 2x10^7 solar masses of gas, requiring a mass transfer rate averaging ~1 solar mass per year unless we are particularly unlucky in viewing angle. Curiously, this demonstrable case of mass transfer seems to be independent of the occurrence of a Seyfert nucleus, since the Seyfert galaxy in this pair is the donor of the material. Likewise, the recipient shows no signs of recent star formation from incoming gas, although NGC 1410 has numerous luminous young star clusters and widespread H-alpha emission.Comment: 27 pages, 9 figures. Accepted for the Astronomical Journal, March 200

Attosecond Streaking in the Water Window: A New Regime of Attosecond Pulse Characterization

We report on the first streaking measurement of water-window attosecond pulses generated via high harmonic generation, driven by sub-2-cycle, CEP-stable, 1850 nm laser pulses. Both the central photon energy and the energy bandwidth far exceed what has been demonstrated thus far, warranting the investigation of the attosecond streaking technique for the soft X-ray regime and the limits of the FROGCRAB retrieval algorithm under such conditions. We also discuss the problem of attochirp compensation and issues regarding much lower photo-ionization cross sections compared with the XUV in addition to the fact that several shells of target gases are accessed simultaneously. Based on our investigation, we caution that the vastly different conditions in the soft X-ray regime warrant a diligent examination of the fidelity of the measurement and the retrieval procedure.Comment: 14 Pages, 12 figure

Distribution and Content of Dust in Overlapping Galaxy Systems

Partially overlapping galaxies are used to directly determine the effective absorption in spiral galaxy disks. The non-overlapping parts of the galaxies and symmetry considerations are used to reconstruct, via differential photometry, how much background galaxy light is lost in passing through the foreground disks.Comment: 4 PostScript pages; to appear in proceedings of "Dust-Morphology" Conference, Johannesburg, South Africa, 22-26 January 1996, ed. D. Block (Dordrecht: Kluwer); also available with 3 PostScript figures at http://www.astr.ua.edu/preprints/white

Tailoring treatment of salivary duct carcinoma (SDC) by liquid biopsy: ARv7 expression in circulating tumor cells

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Circulating Tumor Cells Prediction in Hormone Receptor Positive HER2-Negative Advanced Breast Cancer: A Retrospective Analysis of the MONARCH 2 Trial

Background: The MONARCH 2 trial (NCT02107703) showed the efficacy of abemaciclib, a cyclin-dependent kinase 4 & 6 inhibitor (CDK4/6i), in combination with fulvestrant for hormone receptor-positive, HER2-negative metastatic breast cancer (MBC). The aim of this analysis was to explore the prediction of circulating tumor cells (CTCs) stratification using machine learning for hypothesis generation of biomarker-driven clinical trials. Patients and Methods: Predicted CTCs were computed in the MONARCH 2 trial through a K nearest neighbor (KNN) classifier trained on a dataset comprising 2436 patients with MBC. Patients were categorized into predicted Stage IVaggressive (pStage IVaggressive, ≥5 predicted CTCs) or predicted Stage IVindolent (pStage IVindolent, <5 predicted CTCs). Prognosis was tested in terms of progression-free-survival (PFS) and overall survival (OS) through Cox regression. Results: Patients classified as predicted pStage IVaggressive and predicted pStage Stage IVindolent were, respectively, 183 (28%) and 461 (72%). After multivariable Cox regression, predicted CTCs were confirmed as independently associated with prognosis in terms of OS, together with ECOG performance status, liver involvement, bone-only disease, and treatment arm. Patients in the pStage Stage IVindolent subgroup treated with abemaciclib experienced the best prognosis both in terms of PFS and OS. The treatment effect of abemaciclib on OS was then explored through subgroup analysis, showing a consistent benefit across all subgroups. Conclusion: This study is the first analysis of CTCs modeling for stage IV disease stratification. These results show the need to expand biomarker profiling in combination with CTCs stratification for improved biomarker-driven drug development

Observation and Control of Laser-Enabled Auger Decay

Single photon laser enabled Auger decay (spLEAD) has been redicted theoretically [Phys. Rev. Lett. 111, 083004 (2013)] and here we report its first experimental observation in neon. Using coherent, bichromatic free-electron laser pulses, we have detected the process and coherently controlled the angular distribution of the emitted electrons by varying the phase difference between the two laser fields. Since spLEAD is highly sensitive to electron correlation, this is a promising method for probing both correlation and ultrafast hole migration in more complex systems.Comment: 5 pages, 3 figure

Small Scale Systems of Galaxies. III. X-ray detected E+S galaxy pairs in low density environments

We present a comprehensive study of the local environments of four E+S galaxy pairs with the main goal to investigate their formation/evolution histories. New XMM-Newton data were obtained for two pairs (RR 143 and RR 242) that complements existing ROSAT data for the other two (RR 210 and RR 216). The new observations reveal diffuse X-ray emission in both pairs. The emission is asymmetric in both cases and extends out to 120 kpc and 160 kpc in RR 143 and RR 242 respectively. The nucleus of RR 242 hosts a low luminosity mildly absorbed AGN. We find that the early-type components of pairs with diffuse hot gas appear to be relaxed objects while those in RR 210 and RR 216, where no diffuse emission has been found, display unambiguous signatures of ongoing interaction. Wide-field V and R-band data are used to study the photometric properties of the early-type components and to search for a candidate faint galaxy populations around each of the pairs. While no diffuse optical light is found for any of the pairs, all of the early-type members show very extended and concentric luminous envelopes. We identify a faint galaxy sample in each field and we consider whether they could be physically associated with the luminous pairs based upon (V-R) colors and photometric properties. We find that the distribution of r_e and M_R for the candidates are similar in three of the fields (RR 143, 216 and 242). The same selection criteria applied to the field of RR 210 suggest a fainter and more compact population possibly suggesting a larger background fraction than in the other fields.Comment: 47 pages, 18 figures, Astron. J. in pres

Revealing electronic state-switching at conical intersections in alkyl iodides by ultrafast XUV transient absorption spectroscopy

Conical intersections between electronic states often dictate the chemistry of photoexcited molecules. Recently developed sources of ultrashort extreme ultraviolet (XUV) pulses tuned to element-specific transitions in molecules allow for the unambiguous detection of electronic state-switching at a conical intersection. Here, the fragmentation of photoexcited iso-propyl iodide and tert-butyl iodide molecules (i-C3H7I and t-C4H9I) through a conical intersection between 3Q0/1Q1 spin–orbit states is revealed by ultrafast XUV transient absorption measuring iodine 4d core-to-valence transitions. The electronic state-sensitivity of the technique allows for a complete mapping of molecular dissociation from photoexcitation to photoproducts. In both molecules, the sub-100 fs transfer of a photoexcited wave packet from the 3Q0 state into the 1Q1 state at the conical intersection is captured. The results show how differences in the electronic state-switching of the wave packet in i-C3H7I and t-C4H9I directly lead to differences in the photoproduct branching ratio of the two systems