Linens That Last

What\u27s fun to plan a linen trousseau l Think of the array of colors, the difference of textures and weaves in sheets, towels, and table linens from which you can choose. No need for confusion, though, if you know what to look for before you start

Dream of Summer in the Winter

Winter\u27s a good time for figuring out where you want to go. See that you\u27re comfortably situated in an armchair and begin. A little dreaming and planning for future activities will divert your mind and lift your spirits before those wintry blues bog you down. Make June come in January

The Iowa Homemaker vol.34, no.6

Westgate, Jean Daggett, page 5 AHEA goes to Minneapolis, Jane Hammerly, page 6 Go West in Fashion, Gwen Olson, page 7 Summer Work Calendar, Doris Jirsa and Muriel McLain, page 8 Dream of Summer in the Winter, Jean Redman, page 10 Alum Serves 10,000 Women Every Year, Sally Young, page 12 Viewed by a Waiter, Carolyn Shehan, page 14 What’s New, Mary Vandecar, page 16 Trends, Kay Scholten, page 1

The Iowa Homemaker vol.34, no.3

Star your college goals, Gwen Olson, page 5 Encourage your Cyclones, Carolyn Shehan, page 6 Brighten up, Sally Young, page 9 Dollars for scholars, Becky Metcalf, page 10 Forecast, Donna Mumford, page 12 What’s new, Jean Redman, page 14 That missing leaf, Joan Mertens, page 17 Trends, Kay Scholten, page 1

The Iowa Homemaker vol.34, no.4

Weather or not, Jean Redman, page 5 Flaming dinners, Jane Brintlinger, page 6 You and AHEA, Sally Young, page 7 Polish with wax, Joan Mertens, page 8 What’s new, Donna Mumford, page 10 Sell ISC, Doris Jirsa, page 11 Do it yourself, Mary Vandecar, page 12 Trends, Carolyn Shehan, page 1

A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilatorassociated pneumonia

INTRODUCTION: The aim of this study was to compare a 7-day course of doripenem to a 10-day course of imipenem-cilastatin for ventilator-associated pneumonia (VAP) due to Gram-negative bacteria. METHODS: This was a prospective, double-blinded, randomized trial comparing a fixed 7-day course of doripenem one gram as a four-hour infusion every eight hours with a fixed 10-day course of imipenem-cilastatin one gram as a one-hour infusion every eight hours (April 2008 through June 2011). RESULTS: The study was stopped prematurely at the recommendation of the Independent Data Monitoring Committee that was blinded to treatment arm assignment and performed a scheduled review of data which showed signals that were close to the pre-specified stopping limits. The final analyses included 274 randomized patients. The clinical cure rate at the end of therapy (EOT) in the microbiological intent-to-treat (MITT) population was numerically lower for patients in the doripenem arm compared to the imipenem-cilastatin arm (45.6% versus 56.8%; 95% CI, -26.3% to 3.8%). Similarly, the clinical cure rate at EOT was numerically lower for patients with Pseudomonas aeruginosa VAP, the most common Gram-negative pathogen, in the doripenem arm compared to the imipenem-cilastatin arm (41.2% versus 60.0%; 95% CI, -57.2 to 19.5). All cause 28-day mortality in the MITT group was numerically greater for patients in the doripenem arm compared to the imipenem-cilastatin arm (21.5% versus 14.8%; 95% CI, -5.0 to 18.5) and for patients with P. aeruginosa VAP (35.3% versus 0.0%; 95% CI, 12.6 to 58.0). CONCLUSIONS: Among patients with microbiologically confirmed late-onset VAP, a fixed 7-day course of doripenem was found to have non-significant higher rates of clinical failure and mortality compared to a fixed 10-day course of imipenem-cilastatin. Consideration should be given to treating patients with VAP for more than seven days to optimize clinical outcome. TRIAL REGISTRATION: ClinicalTrials.gov: NCT0058969

The Iowa Homemaker vol.34, no.5

What’s new, Carolyn Shehan, page 4 Christmas, Jane Brintlinger, page 7 Quick to make, Marilyn Mound, page 8 Belle Lowe goes to market, Jean Redman, page 9 Gift guide, Mary Vandecar, page 10 Holiday tables, Gwen Olson, page 12 Your electives have a future, Mary Vandecar, page 14 Is there a Santa Claus?, Mary Anne Larson, page 16 Felt, Carol Krebill, page 18 Heard at Frisco, Dorothy Will, page 19 Chafing dish hot, Kay Scholten, page 20 Trends, Donna Mumford, page 2

A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia

<p>Abstract</p> <p>Background</p> <p>Preeclampsia is a frequent complication of pregnancy and a leading cause of perinatal mortality. Both genetic and environmental risk factors have been identified. Lipid metabolism, particularly cholesterol metabolism, is associated with this disease. Liver X receptors alpha (NR1H3, also known as LXRalpha) and beta (NR1H2, also known as LXRbeta) play a key role in lipid metabolism. They belong to the nuclear receptor superfamily and are activated by cholesterol derivatives. They have been implicated in preeclampsia because they modulate trophoblast invasion and regulate the expression of the endoglin (CD105) gene, a marker of preeclampsia. The aim of this study was to investigate associations between the <it>NR1H3 </it>and <it>NR1H2 </it>genes and preeclampsia.</p> <p>Methods</p> <p>We assessed associations between single nucleotide polymorphisms of <it>NR1H3 </it>(rs2279238 and rs7120118) and <it>NR1H2 </it>(rs35463555 and rs2695121) and the disease in 155 individuals with preeclampsia and 305 controls. Genotypes were determined by high-resolution melting analysis. We then used a logistic regression model to analyze the different alleles and genotypes for those polymorphisms as a function of case/control status.</p> <p>Results</p> <p>We found no association between <it>NR1H3 </it>SNPs and the disease, but the <it>NR1H2 </it>polymorphism rs2695121 was found to be strongly associated with preeclampsia (genotype C/C: adjusted odds ratio, 2.05; 95% CI, 1.04-4.05; <it>p </it>= 0.039 and genotype T/C: adjusted odds ratio, 1.85; 95% CI, 1.01-3.42; <it>p </it>= 0.049).</p> <p>Conclusions</p> <p>This study provides the first evidence of an association between the <it>NR1H2 </it>gene and preeclampsia, adding to our understanding of the links between cholesterol metabolism and this disease.</p

Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/1/aji12860_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/2/aji12860.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/3/aji12860-sup-0001-Supinfo.pd