16 research outputs found

    A Study Of Flexural With Cut Off Intensification Of RC Joist

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    This study presents a final report on adaptive concrete adjustment / bonding system for flexural conditioning of RC participants. The use of adhesive tape in this system has actually reduced the elastic modulus when extending as much as tensile crack. Thus, the bonding line between FRP and concrete can generate a huge shear deviation to delay or prevent the regional UI removal event. Derived from FRP panels / concrete user interface withdrawal tests, research lab tests on constant efficiency along with participant depletion in RC reinforced with FRP sheets, and also reported a complete inspection on a 15m T-beam at this paper. Failed systems for reinforcing participants in typical bonding situations as well as relatively adaptable bonding systems are inspected. In contrast to the typical bonding system, the versatile system has already confirmed its attractive validity in improving the RC spotlight beam for improved stiffness and deformation. However, this method is preferred for the maximum constraint boost function only because it adds a less rigid optimization under the Restricted Service Condition

    A study of age as a risk factor in ischemic stroke of elderly

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    Background: The aim of the study was to determine the effect of age as a risk factor and a determinant of outcome in elderly ischemic stroke patients.Methods: This is an observational study. One hundred, successive elderly patients aged 60 years and above, admitted with acute ischemic stroke in PESIMSR over a period of 18 months were prospectively studied. Patients with hemorrhagic stroke, neurological deficits following trauma or following infection were excluded. Demographics, risk factors, stroke severity at admission were estimated by NIHSS. Risk factors and clinical profile were noted and compared among male and female patients. Outcome at discharge was measured by-mRS-modified ranking score.Results: Patients in age group 60-75 years presented with less severe stroke and better mRS when compared to >75 years age group. Complications were significantly higher among the older age group.Conclusions: The risk factors identified for ischemic stroke in the present study are diabetes, hypertension, dyslipidaemia, obesity, smoking, and alcohol. Severity of stroke at presentation, clinical outcome and complication rate during the in-hospital stay were all significantly affected by the age, more so in ischemic stroke. Age specific factors of stroke prevention are crucial for successful prevention and implementation of well-organized stroke care

    INVESTIGATION, THERAPY AND USE OF MOLECULAR BIOMARKER IN CHRONIC KIDNEY DISEASE

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    Abstract In this article we will discuss anatomy and physiology of kidney in the body. We will define causes, symptoms, stage, complications of chronic kidney disease and use of new technologies of biomarker. When the kidneys are not working properly creatinine levels increased in body, which cause the symptoms of renal failure. Hypertension, tiredness, headache, swelling face and ankles are the symptoms of kidney disease. The Biomarkers use is important for the chronic kidney disease. It is used to confirm the presence of disease. The molecular biomarker in GFR Test is the most important role in chronic renal disease. This study came across the biomarkers of identification of CKD. Disease-specific markers may supplement more general biomarkers. Biomarkers can range from simple physiologic measurements of pulse and blood pressure. Blood samples are test by the help of GFR Test. The GFR is estimated using serum creatinine, a readily available and inexpensive marker. However, serum creatinine varies with age, sex, muscle mass, dietary habits, and medications. Similarly, urine albumin reflects glomerular injury, glomerular permeability, or tubular injury, inflammation, fibrosis, and glomerular hyper filtration .Finally these biomarkers have confirmed the capability to identify early damage, localize injury. Whether the newly identified or kidney biomarkers of underlying pathophysiological processes are purely associations are need to be determine. An approach to bio-marker advance that incorporate mutual with regulatory science involving discipline that is required to make sure that balanced, proof based biomarker development keeps speed with technical and medical need

    Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

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    The drug-induced liver injury network (DILIN) is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study

    Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

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    IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

    Assessing Clinical Global Impressions Severity Scores in an adolescent ASD and DD population across counties

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    The Indiana NeuroDiagnostic Institute (NDI) embodies comprehensive care, stabilization, and transition support for teenagers with autism, across the stages like waitlist, preadmission, admission, discharge, and follow-up, focusing on sustainable community integration and preventing re-admission. The project employs the Clinical Global Impressions (CGI; adapted from Guy, 1976), gauging illness severity and patient progress on a scale of 1 (Normal) to 7 (Extremely ill), assessed preadmission and post-discharge. Most counties initially had high severity scores (7 and 6) but showed a marked shift towards level 5 after leaving the care facility. This positive trend persisted at 1 month, 9 months, and 12 months post-discharge, though data samples were limited. The findings emphasize the enduring benefits of interventions. Factors like individual response variations and external support may have influenced outcomes, warranting further investigation. Overall, the study underscores the effectiveness of tailored interventions for individuals with autism, with potential for broader validation in larger, diverse samples

    Eeficiency of conventional technique and surgical operating microscope in crown lengthening: An original research

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    Background: The success of any  periodontal therapy always depends on better visual access and, magnification is an important component which provides good hand eye coordination with a better treatment outcome. The aim of our study is to assess the effectiveness of magnification over conventional method while performing surgical crown lengthening and to evaluate the patient comfort level and pain perception over a period of 3 months. Methods -The study was conducted amongst 20 patients, 10 in each group requiring crown lengthening for restorative purpose and was evaluated ever a period of 3 months. Results - During 3months follow up, significant differences were found between the groups for probing depth with mean difference of 1.22±0.6, position of gingival margin as with mean  2.7±1.15 and biologic width with mean difference 2.8±0.42.Regarding patient comfort and patients pain perception it was found low for microscope group with mean difference of 2±0.67 Conclusion – A good visual access is a primary requisite behind the success of any periodontal therapy and it was concluded from our study that there was significant reduction in probing depth and improvement in biologic width, gingival margin
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