483 research outputs found
How do SYMPtoms and management tasks in chronic heart failure imPACT a person's life (SYMPACT)? Protocol for a mixed-methods study.
AIMS: Patients with chronic heart failure (CHF) struggle to follow self-care plans, which may lead to worsening illness and poor quality of life. Burden of treatment (BoT) describes this workload and its impact on patients' lives. Suggesting the balance between a patient's treatment workload and their capability to manage it is crucial. If BoT is reduced, self-care engagement and quality of life may improve. This article describes the SYMPACT study design and methods used to explore how symptoms and management tasks impact CHF patients' lives. METHODS AND RESULTS: We used a sequential exploratory mixed-methods design to investigate the interaction between symptoms and BoT in CHF patients. CONCLUSIONS: If symptoms and BoT are intrinsically linked, then the high level of symptoms experienced by CHF patients may lead to increased treatment burden, which likely decreases patients' engagement with self-care plans. SYMPACT may identify modifiable factors to improve CHF patients' experience
Mg/Ti multilayers: structural, optical and hydrogen absorption properties
Mg-Ti alloys have uncommon optical and hydrogen absorbing properties,
originating from a "spinodal-like" microstructure with a small degree of
chemical short-range order in the atoms distribution. In the present study we
artificially engineer short-range order by depositing Pd-capped Mg/Ti
multilayers with different periodicities and characterize them both
structurally and optically. Notwithstanding the large lattice parameter
mismatch between Mg and Ti, the as-deposited metallic multilayers show good
structural coherence. Upon exposure to H2 gas a two-step hydrogenation process
occurs, with the Ti layers forming the hydride before Mg. From in-situ
measurements of the bilayer thickness L at different hydrogen pressures, we
observe large out-of-plane expansions of the Mg and Ti layers upon
hydrogenation, indicating strong plastic deformations in the films and a
consequent shortening of the coherence length. Upon unloading at room
temperature in air, hydrogen atoms remain trapped in the Ti layers due to
kinetic constraints. Such loading/unloading sequence can be explained in terms
of the different thermodynamic properties of hydrogen in Mg and Ti, as shown by
diffusion calculations on a model multilayered systems. Absorption isotherms
measured by hydrogenography can be interpreted as a result of the elastic
clamping arising from strongly bonded Mg/Pd and broken Mg/Ti interfaces
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Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF
The Vela Cloud: A Giant HI Anomaly in the NGC 3256 Group
We present Australia Telescope Compact Array (ATCA) observations of a
galaxy-sized intergalactic HI cloud (the Vela Cloud) in the NGC 3256 galaxy
group. The group contains the prominent merging galaxy NGC 3256, which is
surrounded by a number of HI fragments, the tidally disturbed galaxy NGC 3263,
and several other peculiar galaxies. The Vela Cloud, with an HI mass of 3-5 *
10**9 solar masses, resides southeast of NGC 3256 and west of NGC 3263, within
an area of 9' x 16' (100 kpc x 175 kpc for an adopted distance of 38 Mpc). In
our ATCA data the Vela Cloud appears as 3 diffuse components and contains 4
density enhancements. The Vela Cloud's properties, together with its group
environment, suggest that it has a tidal origin. Each density enhancement
contains ~10**8 solar masses of HI gas which is sufficient material for the
formation of globular cluster progenitors. However, if we represent the
enhancements as Bonnor-Ebert spheres, then the pressure of the surrounding HI
would need to increase by at least a factor of 6 in order to cause the collapse
of an enhancement. Thus we do not expect them to form massive bound stellar
systems like super star clusters or tidal dwarf galaxies. Since the HI density
enhancements have some properties in common with High Velocity Clouds, we
explore whether they may evolve to be identified with these starless clouds
instead.Comment: 47 pages, 13 figures (incl. a & b), accepted by AJ, changes are minor
additions, rearranging, and clarifications esp. in sections 6 &
Adding a Little Reality to Building Ontologies for Biology
BACKGROUND: Many areas of biology are open to mathematical and computational modelling. The application of discrete, logical formalisms defines the field of biomedical ontologies. Ontologies have been put to many uses in bioinformatics. The most widespread is for description of entities about which data have been collected, allowing integration and analysis across multiple resources. There are now over 60 ontologies in active use, increasingly developed as large, international collaborations. There are, however, many opinions on how ontologies should be authored; that is, what is appropriate for representation. Recently, a common opinion has been the "realist" approach that places restrictions upon the style of modelling considered to be appropriate. METHODOLOGY/PRINCIPAL FINDINGS: Here, we use a number of case studies for describing the results of biological experiments. We investigate the ways in which these could be represented using both realist and non-realist approaches; we consider the limitations and advantages of each of these models. CONCLUSIONS/SIGNIFICANCE: From our analysis, we conclude that while realist principles may enable straight-forward modelling for some topics, there are crucial aspects of science and the phenomena it studies that do not fit into this approach; realism appears to be over-simplistic which, perversely, results in overly complex ontological models. We suggest that it is impossible to avoid compromise in modelling ontology; a clearer understanding of these compromises will better enable appropriate modelling, fulfilling the many needs for discrete mathematical models within computational biology
High-Resolution Radio Imaging of Gravitational Lensing Candidates in the 1 Jansky BL Lac Sample
While BL Lacertae objects are widely believed to be highly beamed,
low-luminosity radio galaxies, many radio-selected BL Lacs have extended radio
power levels and optical emission lines that are too luminous to be
low-luminosity radio galaxies. Also, Stocke & Rector discovered an excess of
MgII absorption systems along BL Lac sightlines compared to quasars, suggesting
that gravitational lensing may be another means of creating the BL Lac
phenomenon in some cases. We present a search for gravitationally-lensed BL
Lacs with deep, high-resolution, two-frequency VLA radio maps of seven lensing
candidates from the 1 Jansky BL Lac sample. We find that none of these objects
are resolved into an Einstein ring like B 0218+357, nor do any show multiple
images of the core. All of the lensing candidates that were resolved show a
flat-spectrum core and very unusual, steep-spectrum extended morphology that is
incompatible with a multiply lensed system. Thus, while these observations do
not rule out microlensing, no macrolensing is observed.Comment: Accepted, A
Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients
BACKGROUND/OBJECTIVES: Heart rate recovery (HRR), a cardiac autonomic control marker, was shown to be related to body composition (BC), yet this was not tested in non-alcoholic fatty liver disease (NAFLD) patients. The aim of this study was to determine if, and to what extent, markers of BC and body fat (BF) distribution are related to cardiac autonomic control in NAFLD patients. SUBJECTS/METHODS: BC was assessed with dual-energy X-ray absorptiometry in 28 NAFLD patients (19 men, 51±13 years, and 9 women, 47±13 years). BF depots ratios were calculated to assess BF distribution. Subjects’ HRR was recorded 1 (HRR1) and 2 min (HRR2) immediately after a maximum graded exercise test.
RESULTS: BC and BF distribution were related to HRR; particularly weight, trunk BF and trunk BF-to-appendicular BF ratio showed a negative relation with HRR1 (r 1⁄4 0.613, r 1⁄4 0.597 and r 1⁄4 0.547, respectively, Po0.01) and HRR2 (r 1⁄4 0.484, r 1⁄4 0.446, Po0.05, and r 1⁄4 0.590, Po0.01, respectively). Age seems to be related to both HRR1 and HRR2 except when controlled for BF distribution. The preferred model in multiple regression should include trunk BF-to-appendicular BF ratio and BF to predict HRR1 (r2 1⁄4 0.549; Po0.05), and trunk BF-to-appendicular BF ratio alone to predict HRR2 (r2 1⁄4 0.430; Po0.001).
CONCLUSIONS: BC and BF distribution were related to HRR in NAFLD patients. Trunk BF-to-appendicular BF ratio was the best independent predictor of HRR and therefore may be best related to cardiovascular increased risk, and possibly act as a mediator in age-related cardiac autonomic control variation.info:eu-repo/semantics/publishedVersio
Beyond Volume: The Impact of Complex Healthcare Data on the Machine Learning Pipeline
From medical charts to national census, healthcare has traditionally operated
under a paper-based paradigm. However, the past decade has marked a long and
arduous transformation bringing healthcare into the digital age. Ranging from
electronic health records, to digitized imaging and laboratory reports, to
public health datasets, today, healthcare now generates an incredible amount of
digital information. Such a wealth of data presents an exciting opportunity for
integrated machine learning solutions to address problems across multiple
facets of healthcare practice and administration. Unfortunately, the ability to
derive accurate and informative insights requires more than the ability to
execute machine learning models. Rather, a deeper understanding of the data on
which the models are run is imperative for their success. While a significant
effort has been undertaken to develop models able to process the volume of data
obtained during the analysis of millions of digitalized patient records, it is
important to remember that volume represents only one aspect of the data. In
fact, drawing on data from an increasingly diverse set of sources, healthcare
data presents an incredibly complex set of attributes that must be accounted
for throughout the machine learning pipeline. This chapter focuses on
highlighting such challenges, and is broken down into three distinct
components, each representing a phase of the pipeline. We begin with attributes
of the data accounted for during preprocessing, then move to considerations
during model building, and end with challenges to the interpretation of model
output. For each component, we present a discussion around data as it relates
to the healthcare domain and offer insight into the challenges each may impose
on the efficiency of machine learning techniques.Comment: Healthcare Informatics, Machine Learning, Knowledge Discovery: 20
Pages, 1 Figur
Hierarchical Structure Formation and Modes of Star Formation in Hickson Compact Group 31
The handful of low-mass, late-type galaxies that comprise Hickson Compact
Group 31 is in the midst of complex, ongoing gravitational interactions,
evocative of the process of hierarchical structure formation at higher
redshifts. With sensitive, multicolor Hubble Space Telescope imaging, we
characterize the large population of <10 Myr old star clusters that suffuse the
system. From the colors and luminosities of the young star clusters, we find
that the galaxies in HCG 31 follow the same universal scaling relations as
actively star-forming galaxies in the local Universe despite the unusual
compact group environment. Furthermore, the specific frequency of the globular
cluster system is consistent with the low end of galaxies of comparable masses
locally. This, combined with the large mass of neutral hydrogen and tight
constraints on the amount of intragroup light, indicate that the group is
undergoing its first epoch of interaction-induced star formation. In both the
main galaxies and the tidal-dwarf candidate, F, stellar complexes, which are
sensitive to the magnitude of disk turbulence, have both sizes and masses more
characteristic of z=1-2 galaxies. After subtracting the light from compact
sources, we find no evidence for an underlying old stellar population in F --
it appears to be a truly new structure. The low velocity dispersion of the
system components, available reservoir of HI, and current star formation rate
of ~10 solar masses per year, indicate that HCG31 is likely to both exhaust its
cold gas supply and merge within ~1 Gyr. We conclude that the end product will
be an isolated, X-ray-faint, low-mass elliptical.Comment: 24 pages, 14 figures (including low resolution versions of color
images), latex file prepared with emulateapj. Accepted for publication by the
Astronomical Journa
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