14 research outputs found
Orientation of Galaxies in the Local Supercluster: A Review
The progress of the studies on the orientation of galaxies in the Local
Supercluster (LSC) is reviewed and a summary of recent results is given.
Following a brief introduction of the LSC, we describe the results of early
studies based on two-dimensional analysis, which were mostly not conclusive. We
describe next the three-dimensional analysis, which is used widely today.
Difficulties and systematic effects are explained and the importance of
selection effects is described. Then, results based on the new method and
modern databases are given, which are summarized as follows. When the LSC is
seen as a whole, galaxy planes tend to align perpendicular to the LSC plane
with lenticulars showing the most pronounced tendency. Projections onto the LSC
plane of the spin vectors of Virgo cluster member galaxies, and to some extent,
those of the total LSC galaxies, tend to point to the Virgo cluster center.
This tendency is more pronounced for lenticulars than for spirals. It is
suggested that 'field' galaxies, i.e., those which do not belong to groups with
more than three members, may be better objects than other galaxies to probe the
information at the early epoch of the LSC formation through the analysis of
galaxy orientations. Field lenticulars show a pronounced anisotropic
distribution of spin vectors in the sense that they lay their spin vectors
parallel to the LSC plane while field spirals show an isotropic spin-vector
distribution.Comment: 21 pages, 10 figures; Accepted for publication in Astrophysics and
Space Scienc
Association study of parkin gene polymorphisms with idiopathic Parkinson disease
Background Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD.
Objective To investigate the association of 7 previously studied Parkin single-nucleotide polymorphisms (SNPs) throughout the promoter and most of the open reading frame with PD in a large cohort of patients with primarily late-onset PD.
Methods One promoter, 3 intronic, and 3 exonic Parkin SNPs were genotyped in 1580 individuals belonging to 397 families, and their association with PD was evaluated using family-based association tests.
Results No significant association (P>.05) between PD and any Parkin SNP allele or genotype was detected. Haplotype analysis and stratification by age at onset or family history also failed to produce significant results.
Conclusions These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD