Near-infrared photoluminescence of erbium tris(8-hydroxyquinoline) spin-coated thin films induced by low coherence light sources

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Bright X-ray flares in Orion young stars from COUP: evidence for star-disk magnetic fields?

We have analyzed a number of intense X-ray flares observed in the Chandra Orion Ultradeep Project (COUP), a 13 days observation of the Orion Nebula Cluster (ONC). Analysis of the flare decay allows to determine the size, peak density and magnetic field of the flaring structure. A total of 32 events (the most powerful 1% of COUP flares), have sufficient statistics for the analysis. A broad range of decay times (from 10 to 400 ks) are present in the sample. Peak flare temperatures are often very high, with half of the flares in the sample showing temperatures in excess of 100 MK. Significant sustained heating is present in the majority of the flares. The magnetic structures which are found, are in a number of cases very long, with semi-lengths up to 10^12 cm, implying the presence of magnetic fields of hundreds of G extending to comparable distance from the stellar photosphere. These very large sizes for the flaring structures ($ >> R_*) are not found in more evolved stars, where, almost invariably, the same type of analysis results in structures with L <= R_*. As the majority of young stars in the ONC are surrounded by disks, we speculate that the large magnetic structures which confine the flaring plasma are actually the same type of structures which channel the plasma in the magnetospheric accretion paradigm, connecting the star's photosphere with the accretion disk.Comment: Accepted to ApJS, COUP special issu

X-ray flares in Orion young stars. I. Flare characteristics

Pre-main sequence (PMS) stars are known to produce powerful X-ray flares which resemble magnetic reconnection solar flares scaled by factors up to 10^4. However, numerous puzzles are present including the structure of X-ray emitting coronae and magnetospheres, effects of protoplanetary disks, and effects of stellar rotation. To investigate these issues in detail, we examine 216 of the brightest flares from 161 PMS stars observed in the Chandra Orion Ultradeep Project (COUP). These constitute the largest homogeneous dataset of PMS, or indeed stellar flares at any stellar age, ever acquired. Our effort is based on a new flare spectral analysis technique that avoids nonlinear parametric modeling. It can be applied to much weaker flares and is more sensitive than standard methods. We provide a catalog with >30 derived flare properties and an electronic atlas for this unique collection of stellar X-ray flares. The current study (Paper I) examines the flare morphologies, and provides general comparison of COUP flare characteristics with those of other active X-ray stars and the Sun. Paper II will concentrate on relationships between flare behavior, protoplanetary disks, and other stellar properties. Several results are obtained. First, the COUP flares studied here are among the most powerful, longest, and hottest stellar X-ray flares ever studied. Second, no significant statistical differences in peak flare luminosity or temperature distributions are found among different morphological flare classes, suggesting a common underlying mechanism for all flares. Third, comparison with the general solar-scaling laws indicates that COUP flares may not fit adequately proposed power-temperature and duration-temperature solar-stellar fits. Fourth, COUP super-hot flares are found to be brighter but shorter than ... ABRIDGEDComment: Accepted for publication in ApJ (07/11/08); 63 pages, 16 figures, 4 table

Influence of experimental parameters on in vitro human skin permeation of Bisphenol A.

Bisphenol A (BPA) in vitro skin permeation studies have shown inconsistent results, which could be due to experimental conditions. We studied the impact of in vitro parameters on BPA skin permeation using flow-through diffusion cells with ex-vivo human skin (12 donors, 3-12 replicates). We varied skin status (viable or frozen skin) and thickness (200, 400, 800 μm), BPA concentrations (18, 250 mg/l) and vehicle volumes (10, 100 and 1000 μl/cm &lt;sup&gt;2&lt;/sup&gt; ). These conditions led to a wide range of BPA absorption (2%-24% after 24 h exposure), peak permeation rates (J = 0.02-1.31 μg/cm &lt;sup&gt;2&lt;/sup&gt; /h), and permeability coefficients (K &lt;sub&gt;p&lt;/sub&gt; = 1.6-5.2 × 10 &lt;sup&gt;-3&lt;/sup&gt; cm/h). This is the first time steady state conditions were reached for BPA aqueous solutions in vitro (1000 μl/cm &lt;sup&gt;2&lt;/sup&gt; applied at concentration 250 mg/l). A reduction of the skin thickness from 800 and 400 μm to 200 μm led to a 3-fold increase of J (P &lt; 0.05). A reduction of the vehicle volume from 1000 to 100 led to a 2-fold decrease in J (P &gt; 0.05). Previously frozen skin led to a 3-fold increase in J compared to viable skin (P &lt; 0.001). We found that results from published studies were consistent when adjusting J according to experimental parameters. We propose appropriate J values for different exposure scenarios to calculate BPA internal exposures for use in risk assessment

Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

Objective. Tranexamic acid (TXA) is increasingly used in orthopedic surgery to reduce blood loss; however, there are concerns about the risk of venous thromboembolic (VTE) complications. The aim of this study was to evaluate TXA safety in patients undergoing lower limb orthopedic surgical procedures. Design. A meta-analysis was performed on the PubMed, Web of Science, and Cochrane Library databases in January 2020 using the following string (Tranexamic acid) AND ((knee) OR (hip) OR (ankle) OR (lower limb)) to identify RCTs about TXA use in patients undergoing every kind of lower limb surgical orthopedic procedures, with IV, IA, or oral administration, and compared with a control arm to quantify the VTE complication rates. Results. A total of 140 articles documenting 9,067 patients receiving TXA were identified. Specifically, 82 studies focused on TKA, 41 on THA, and 17 on other surgeries, including anterior cruciate ligament reconstruction, intertrochanteric fractures, and meniscectomies. The intravenous TXA administration protocol was studied in 111 articles, the intra-articular in 45, and the oral one in 7 articles. No differences in terms of thromboembolic complications were detected between the TXA and control groups neither in the overall population (2.4% and 2.8%, respectively) nor in any subgroup based on the surgical procedure and TXA administration route. Conclusions. There is an increasing interest in TXA use, which has been recently broadened from the most common joint replacement procedures to the other types of surgeries. Overall, TXA did not increase the risk of VTE complications, regardless of the administration route, thus supporting the safety of using TXA for lower limb orthopedic surgical procedures

dReDBox: Materializing a full-stack rack-scale system prototype of a next-generation disaggregated datacenter

Current datacenters are based on server machines, whose mainboard and hardware components form the baseline, monolithic building block that the rest of the system software, middleware and application stack are built upon. This leads to the following limitations: (a) resource proportionality of a multi-tray system is bounded by the basic building block (mainboard), (b) resource allocation to processes or virtual machines (VMs) is bounded by the available resources within the boundary of the mainboard, leading to spare resource fragmentation and inefficiencies, and (c) upgrades must be applied to each and every server even when only a specific component needs to be upgraded. The dRedBox project (Disaggregated Recursive Datacentre-in-a-Box) addresses the above limitations, and proposes the next generation, low-power, across form-factor datacenters, departing from the paradigm of the mainboard-as-a-unit and enabling the creation of function-block-as-a-unit. Hardware-level disaggregation and software-defined wiring of resources is supported by a full-fledged Type-1 hypervisor that can execute commodity virtual machines, which communicate over a low-latency and high-throughput software-defined optical network. To evaluate its novel approach, dRedBox will demonstrate application execution in the domains of network functions virtualization, infrastructure analytics, and real-time video surveillance.This work has been supported in part by EU H2020 ICTproject dRedBox, contract #687632.Peer ReviewedPostprint (author's final draft

Rainbow trout (Oncorhynchus mykiss, Walbaum 1792) develop a more robust body shape under organic rearing

Prolonged exposure to captive conditions has led to the development of a rainbow trout ‘farmed’ pheno- type, which is different from that of wild trout. Selec- tion for desirable productive traits in hatcheries has resulted in the development of some morphological traits that are maladaptive in nature. The recent development of organic aquaculture, guided by the well-being of the fish, could potentially produce a new farmed phenotype that would be more adaptive in nature. In this study, rainbow trout reared in intensive and organic farms were compared by means of shape analysis, to detect patterns of shape variation associated with rearing environment. The results of this study highlight a significant effect of the rearing method on rainbow trout shape: organi- cally reared trout showed a higher body profile, in particular in the head and trunk regions, shorter median fins and a deeper caudal peduncle. A combined effect of density and habitat complexity could have contributed to the observed shape differences: in organic rearing systems, lower densi- ties and steady water could increase territoriality and aggressive interactions, promoting body designs more functional in rapid attacks and escapes