DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE MUCOADHESIVE MICROBEADS CONTAINING SIMVASTATIN WITH DIFFERENT CROSS LINKING AGENTS

Objective: The aim of the present work was to prepare and examine drug release of the oral controlled release microbeads using different curing agents by emulsification internal ionic gelation technique. Methods: Cross-linked alginate microbeads were prepared with different cross linking agents by using mucoadhesive properties. The formation and compatibility of microbeads were confirmed by compatibility studies. Prepared microbeads evaluated for encapsulated efficiency, micromeritic properties, drug loading, in vitro wash off studies, in vitro dissolution studies, drug release kinetics and stability studies Results: The in vitro drug release was influenced by both type of curing agents and type of polymers and no significant changes in characterization parameters was observed after 3 mo stability studies. The sustained release profile of optimized batch was found to be 99.66±0.18% in comparison to pure drug profile of 28.64±0.02% at 12 h release study. Results of both wash-off and in vitro studies suggests that batch (SF2) prepared with aluminium chloride has shown better mucoadhesive property. Drug release of optimized batch follows zero order with non fickian mechanism according to Korsmeyer-Peppas equation. Conclusion: The data suggest the use of simvastatin mucoadhesive cross linked microbeads to offer the potential for oral controlled drug delivery with improved gastric retention and capable to provide sustained drug release by using cross linking agents

Mossbauer & Other Spectral Studies on Iron(III) Complexes with Ligands Containing Amide Group

485-48

Effect of Kayyonyadi churna in the management of Pandu roga (Anaemia)

Pandu roga is one of the diseases mentioned in Ayurveda characterized by the whitish discolouration of the skin due to the loss of blood. The disease is comparable with Anaemia in the modern medical literature. The incidence of the problem is high in school going children, adolescents and pregnant women. So to find a cost effective remedy for the management of anaemia, Kayyonyadi churna is taken for the study which contains most of the commonly available plants and Mandura bhasma. Both of them act to reduce the Anaemia by virtue of their properties and acts as a supplement of Iron. An open end clinical trial was taken up for the study on 30 patients and 1-2 gms of the churna is given twice daily along with Takra for 30 days. It was observed from the study that the drug showed marked reduction in the clinical symptoms (p value <0.0001) and improvement in the Hb% (p value <0.0001)

A formal stereoselective synthesis of (−)-maurenone

An efficient formal synthesis of marine polypropionate (−)-maurenone is described. Highlights of the strategy include the utilization of a desymmetrization technique and the activation of the epoxide oxygen with a silyl triflate followed by intramolecular -hydride transfer - a novel transformation

Total synthesis of (+)-bourgeanic acid utilizing desymmetrization strategy

A highly stereoselective total synthesis of an aliphatic depside (+)-bourgeanic acid via (-)-hemibourgeanic acid and bourgeanic lactone is described. The key steps involved in this synthesis are desymmetrization of bicyclic olefin with Brown's asymmetric hydroboration, Gillman's reaction, TEMPO-BAIB mediated selective oxidation of 1,3-diol, Yamaguchi macro-lactonization and LiOH-mediated partial hydrolysis of unusually stable eight-membered cyclic dilactone

Total synthesis of (+)-aculeatin D and (+)-6-epi-aculeatin D

The stereoselective total synthesis of spiroketal natural product (+)-aculeatin D and unnatural (+)-6-epi-aculeatin D has been accomplished. Sharpless kinetic resolution of secondary allylic alcohol and phenyliodine(III) bis(trifluoroacetate) (PIFA)-mediated oxidative spirocyclization were used as key steps in this synthesis

Correlation between structural, magnetic and spectroscopic properties of Mg substituted CoFe2O4

Mg substituted cobalt ferrite spinel powder samples with the general formula MgxCo1-xFe2O4 (x = 0 to 0.25) were synthesized chemically through sol-gel method and annealed at 1100 degrees C for 2 h. They were initially screened for the structural and morphological properties by X-ray diffraction and field emission scanning electron microscopy, respectively. Vibrational properties of the samples were studied by Raman and infrared spectroscopies. X-ray diffraction confirmed the formation of single pure or near-pure phase with cubic spinel structure for all the samples with expected occupancy values. The field emission scanning electron microscopy revealed a decrease in the particle size with an increase in Mg concentration. Both structural and magnetic properties of the samples were characterized using Mossbauer spectroscopy while the magnetic properties were studied using vibrating sample magnetometry. The changes in magnetic moment of ions, their coupling with neighboring ions and cation exchange interactions were confirmed from the Mossbauer spectroscopy analysis. Saturation magnetization and coercivity values can be explained based on the Slater-Pauling curve. The magnetometry results showed a decrease in saturation magnetization of the samples with increase in Mg concentration

Stereoseletive total synthesis of 11-α-and 11-β-methoxycurvularins

Total synthesis of 11-α-methoxycurvularin and 11-β-methoxycurvularin has been accomplished in a highly stereoselective manner by utilizing Jacobsen hydrolytic kinetic resolution, Maruoka asymmetric allylation and intramolecular Friedel-Crafts acylation as key steps

Total synthesis of xestodecalactone C from L-malic acid

An efficient total synthesis of the ten-membered macrolide, xestodecalactone C is described. The synthetic sequence uses Barbier-allylation, LiAlH<SUB>4</SUB>/LiI-mediated syn-stereoselective 1,3-asymmetric reduction, and intramolecular Friedel-Crafts acylation as key steps