Successful transition from fed-batch to continuous manufacturing within a mAb process development cycle

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An Approximation for the rp-Process

Hot (explosive) hydrogen burning or the Rapid Proton Capture Process (rp-process) occurs in a number of astrophysical environments. Novae and X-ray bursts are the most prominent ones, but accretion disks around black holes and other sites are candidates as well. The expensive and often multidimensional hydro calculations for such events require an accurate prediction of the thermonuclear energy generation, while avoiding full nucleosynthesis network calculations. In the present investigation we present an approximation scheme applicable in a temperature range which covers the whole range of all presently known astrophysical sites. It is based on the concept of slowly varying hydrogen and helium abundances and assumes a kind of local steady flow by requiring that all reactions entering and leaving a nucleus add up to a zero flux. This scheme can adapt itself automatically and covers situations at low temperatures, characterized by a steady flow of reactions, as well as high temperature regimes where a $(p,\gamma)-(\gamma,p)$-equilibrium is established. In addition to a gain of a factor of 15 in computational speed over a full network calculation, and an energy generation accurate to more than 15 %, this scheme also allows to predict correctly individual isotopic abundances. Thus, it delivers all features of a full network at a highly reduced cost and can easily be implemented in hydro calculations.Comment: 18 pages, LaTeX using astrobib and aas2pp4, includes PostScript figures; Astrophysical Journal, in press. PostScript source also available at http://quasar.physik.unibas.ch/preps.htm

Future changes in snowmelt-driven runoff timing over the western US

We use a high-resolution nested climate model to investigate future changes in snowmelt-driven runoff (SDR) over the western US. Comparison of modeled and observed daily runoff data reveals that the regional model captures the present-day timing and trends of SDR. Results from an A2 scenario simulation indicate that increases in seasonal temperature of approximately 3° to 5°C resulting from increasing greenhouse gas concentrations could cause SDR to occur as much as two months earlier than present. These large changes result from an amplified snow-albedo feedback driven by the topographic complexity of the region, which is more accurately resolved in a high-resolution nested climate model. Earlier SDR could affect water storage in reservoirs and hydroelectric generation, with serious consequences for land use, agriculture, and water management in the American West

ATLAST detector needs for direct spectroscopic biosignature characterization in the visible and near-IR

Are we alone? Answering this ageless question will be a major focus for astrophysics in coming decades. Our tools will include unprecedentedly large UV-Optical-IR space telescopes working with advanced coronagraphs and starshades. Yet, these facilities will not live up to their full potential without better detectors than we have today. To inform detector development, this paper provides an overview of visible and near-IR (VISIR; $\lambda=0.4-1.8~\mu\textrm{m}$) detector needs for the Advanced Technology Large Aperture Space Telescope (ATLAST), specifically for spectroscopic characterization of atmospheric biosignature gasses. We also provide a brief status update on some promising detector technologies for meeting these needs in the context of a passively cooled ATLAST.Comment: 8 pages, Presented 9 August 2015 at SPIE Optics + Photonics, San Diego, C

Hybrid Fiber Layup and Fiber-Reinforced Polymeric Composites Produced Therefrom

Embodiments of a hybrid fiber layup used to form a fiber-reinforced polymeric composite, and a fiber-reinforced polymeric composite produced therefrom are disclosed. The hybrid fiber layup comprises one or more dry fiber strips and one or more prepreg fiber strips arranged side by side within each layer, wherein the prepreg fiber strips comprise fiber material impregnated with polymer resin and the dry fiber strips comprise fiber material without impregnated polymer resin

Projected Future Changes in Vegetation in Western North America in the Twenty-First Century

Rapid and broad-scale forest mortality associated with recent droughts, rising temperature, and insect outbreaks has been observed over western North America (NA). Climate models project additional future warming and increasing drought and water stress for this region. To assess future potential changes in vegetation distributions in western NA, the Community Earth System Model (CESM) coupled with its Dynamic Global Vegetation Model (DGVM) was used under the future A2 emissions scenario. To better span uncertainties in future climate, eight sea surface temperature (SST) projections provided by phase 3 of the Coupled Model Intercomparison Project (CMIP3) were employed as boundary conditions. There is a broad consensus among the simulations, despite differences in the simulated climate trajectories across the ensemble, that about half of the needleleaf evergreen tree coverage (from 24% to 11%) will disappear, coincident with a 14% (from 11% to 25%) increase in shrubs and grasses by the end of the twenty-first century in western NA, with most of the change occurring over the latter half of the twenty-first century. The net impact is a ~6 GtC or about 50% decrease in projected ecosystem carbon storage in this region. The findings suggest a potential for a widespread shift from tree-dominated landscapes to shrub and grass-dominated landscapes in western NA because of future warming and consequent increases in water deficits. These results highlight the need for improved process-based understanding of vegetation dynamics, particularly including mortality and the subsequent incorporation of these mechanisms into earth system models to better quantify the vulnerability of western NA forests under climate change

Projected Future Changes in Vegetation in Western North America in the Twenty-First Century

Rapid and broad-scale forest mortality associated with recent droughts, rising temperature, and insect outbreaks has been observed over western North America (NA). Climate models project additional future warming and increasing drought and water stress for this region. To assess future potential changes in vegetation distributions in western NA, the Community Earth System Model (CESM) coupled with its Dynamic Global Vegetation Model (DGVM) was used under the future A2 emissions scenario. To better span uncertainties in future climate, eight sea surface temperature (SST) projections provided by phase 3 of the Coupled Model Intercomparison Project (CMIP3) were employed as boundary conditions. There is a broad consensus among the simulations, despite differences in the simulated climate trajectories across the ensemble, that about half of the needleleaf evergreen tree coverage (from 24% to 11%) will disappear, coincident with a 14% (from 11% to 25%) increase in shrubs and grasses by the end of the twenty-first century in western NA, with most of the change occurring over the latter half of the twenty-first century. The net impact is a ~6 GtC or about 50% decrease in projected ecosystem carbon storage in this region. The findings suggest a potential for a widespread shift from tree-dominated landscapes to shrub and grass-dominated landscapes in western NA because of future warming and consequent increases in water deficits. These results highlight the need for improved process-based understanding of vegetation dynamics, particularly including mortality and the subsequent incorporation of these mechanisms into earth system models to better quantify the vulnerability of western NA forests under climate change

Detection of a Westward Hotspot Offset in the Atmosphere of a Hot Gas Giant CoRoT-2b

Short-period planets exhibit day-night temperature contrasts of hundreds to thousands of degrees K. They also exhibit eastward hotspot offsets whereby the hottest region on the planet is east of the substellar point; this has been widely interpreted as advection of heat due to eastward winds. We present thermal phase observations of the hot Jupiter CoRoT-2b obtained with the IRAC instrument on the Spitzer Space Telescope. These measurements show the most robust detection to date of a westward hotspot offset of 23 $\pm$ 4 degrees, in contrast with the nine other planets with equivalent measurements. The peculiar infrared flux map of CoRoT-2b may result from westward winds due to non-synchronous rotation magnetic effects, or partial cloud coverage, that obscures the emergent flux from the planet's eastern hemisphere. Non-synchronous rotation and magnetic effects may also explain the planet's anomalously large radius. On the other hand, partial cloud coverage could explain the featureless dayside emission spectrum of the planet. If CoRoT-2b is not tidally locked, then it means that our understanding of star-planet tidal interaction is incomplete. If the westward offset is due to magnetic effects, our result represents an opportunity to study an exoplanet's magnetic field. If it has Eastern clouds, then it means that our understanding of large-scale circulation on tidally locked planets is incomplete.Comment: 30 pages, 4 figures, 15 supplementary figure

NIMBUS: The Near-Infrared Multi-Band Ultraprecise Spectroimager for SOFIA

We present a new and innovative near-infrared multi-band ultraprecise spectroimager (NIMBUS) for SOFIA. This design is capable of characterizing a large sample of extrasolar planet atmospheres by measuring elemental and molecular abundances during primary transit and occultation. This wide-field spectroimager would also provide new insights into Trans-Neptunian Objects (TNO), Solar System occultations, brown dwarf atmospheres, carbon chemistry in globular clusters, chemical gradients in nearby galaxies, and galaxy photometric redshifts. NIMBUS would be the premier ultraprecise spectroimager by taking advantage of the SOFIA observatory and state of the art infrared technologies. This optical design splits the beam into eight separate spectral bandpasses, centered around key molecular bands from 1 to 4 microns. Each spectral channel has a wide field of view for simultaneous observations of a reference star that can decorrelate time-variable atmospheric and optical assembly effects, allowing the instrument to achieve ultraprecise calibration for imaging and photometry for a wide variety of astrophysical sources. NIMBUS produces the same data products as a low-resolution integral field spectrograph over a large spectral bandpass, but this design obviates many of the problems that preclude high-precision measurements with traditional slit and integral field spectrographs. This instrument concept is currently not funded for development.Comment: 14 pages, 9 figures, SPIE Astronomical Telescopes and Instrumentation 201