Letter: Faecal volatile organic metabolites, promising biomarkers in inflammatory bowel disease and Letter: Faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Authors' reply

The aetiology of inflammatory bowel disease (IBD) remains poorly understood. Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may be associated with changes in faecal volatile organic metabolites (VOMs).To describe the changes in the faecal VOMs of patients with IBD and establish their diagnostic potential as non-invasive biomarkers.Faecal samples were obtained from 117 people with Crohn's disease (CD), 100 with ulcerative colitis (UC), and 109 healthy controls. Faecal VOMs were extracted using solid-phase micro-extraction and analysed by gas chromatography mass spectrometry. Data analysis was carried out using partial least squares-discriminate analysis (PLS-DA) to determine class membership based on distinct metabolomic profiles.The PLS-DA model showed clear separation of active CD from inactive disease and healthy controls (P < 0.001). Heptanal, 1-octen-3-ol, 2-piperidinone and 6-methyl-2-heptanone were up-regulated in the active CD group [variable important in projection (VIP) score 2.8, 2.7, 2.6 and 2.4, respectively], while methanethiol, 3-methyl-phenol, short-chain fatty acids and ester derivatives were found to be less abundant (VIP score of 3.5, 2.6, 1.5 and 1.2, respectively). The PLS-DA model also separated patients with small bowel CD from healthy controls and those with colonic CD from UC (P < 0.001). In contrast, less distinct separation was observed between active UC, inactive UC and healthy controls.Analysis of faecal volatile organic metabolites can provide an understanding of gut metabolomic changes in IBD. It has the potential to provide a non-invasive means of diagnosing IBD, and can differentiate between UC and CD

‘Ethnic group’, the state and the politics of representation

The assertion, even if only by implication, that ‘ethnic group’ categories represent ‘real’ tangible entities, indeed identities, is commonplace not only in the realms of political and policy discourse but also amongst contemporary social scientists. This paper, following Brubaker (2002), questions this position in a number of key respects: of these three issues will dominate the discussion that follows. First, there is an interrogation of the proposition that those to whom the categories/labels refer constitute sociologically meaningful ‘groups’ as distinct from (mere) human collectivities. Secondly, there is the question of how these categories emerge, i.e. exactly what series of events, negotiations and contestations lie behind their construction and social acceptance. Thirdly, and as a corollary to the latter point, we explore the process of reification that leads to these categories being seen to represent ‘real things in the world’ (ibid.)

Razvojni prospekti bankarstva u novim i budućim zemljama članicama EU

Bank consolidation has substantially decreased the number of banks in European banking, which has had important implications for the banking sectors structure in all EU member countries. The consolidation processes have had a tremendous impact on the developments in banking sectors of new EU member countries, where major structural changes have been initiated mostly by new entrant banks from the old EU member countries. The future banking development in new EU member countries will very likely follow some main patterns known from the old EU members. Rather speculative conjectures, which are based on a comparison with banking sectors in other EU member countries indicate, that the total-asset-to-GDP ratio in new member countries should further improve in the future. The banking sector growth will be based mostly on the growth of the credit to non-banking sector, while banks are not expected anymore to use non-bank deposits as a predominant way of funding. Instead potentials for alternative funding possibilities should be activated. Although the non-bank financial intermediaries in new EU members represent a serious competition to banks, their relative underdevelopment prevents them from impacting the developments in banking sectors as known from old EU member countries.Konsolidacija banaka znatno je smanjila broj banaka u europskom bankarstvu, što ima značajne implikacije na bankarski sektor u svim zemljama članicama EU. Konsolidacija banaka imala je veliki utjecaj na razvoj bankarskog sektora svih novih zemalja članica, gdje su najveće strukturalne promjene inicirane stvaranjem novih banaka uz sudioništvo starih članica EU. Budući bankarski razvoj u novim zemljama članicama EU vjerojatno će se temeljiti na onom starih članica. Više spekulativna nagađanja, koja se temelje na usporedbi s bankarskim sektorima u drugim zemljama članicama, pokazuju da će se odnos kapitala prema BDP u novim zemljama članicama povećavati u budućnosti. Rast bankarskog sektora temeljit će se većim dijelom na rastu zajmova nebankarskim sektorima, a od banaka se očekuje da više ne rabe nebankarske depozite kao glavni oblik financiranja. Umjesto toga, trebaju se aktivirati mogućnosti za alternativnim financiranjem. Nebankarski financijski posrednici u novim zemljama članicama EU bankama predstavljaju ozbiljnu konkurenciju, međutim, njihova relativna nerazvijenost sprečava ih da utječu na razvoj u bankarskom sektoru kao što je to bio slučaj u starim zemljama članicama EU

Peaks in the Hartle-Hawking Wave Function from Sums over Topologies

Recent developments in ``Einstein Dehn filling'' allow the construction of infinitely many Einstein manifolds that have different topologies but are geometrically close to each other. Using these results, we show that for many spatial topologies, the Hartle-Hawking wave function for a spacetime with a negative cosmological constant develops sharp peaks at certain calculable geometries. The peaks we find are all centered on spatial metrics of constant negative curvature, suggesting a new mechanism for obtaining local homogeneity in quantum cosmology.Comment: 16 pages,LaTeX, no figures; v2: some changes coming from revision of a math reference: wave function peaks sharp but not infinite; v3: added paragraph in intro on interpretation of wave functio

A return to strong radio flaring by Circinus X-1 observed with the Karoo Array Telescope test array KAT-7

Circinus X-1 is a bright and highly variable X-ray binary which displays strong and rapid evolution in all wavebands. Radio flaring, associated with the production of a relativistic jet, occurs periodically on a ~17-day timescale. A longer-term envelope modulates the peak radio fluxes in flares, ranging from peaks in excess of a Jansky in the 1970s to an historic low of milliJanskys during the years 1994 to 2007. Here we report first observations of this source with the MeerKAT test array, KAT-7, part of the pathfinder development for the African dish component of the Square Kilometre Array (SKA), demonstrating successful scientific operation for variable and transient sources with the test array. The KAT-7 observations at 1.9 GHz during the period 13 December 2011 to 16 January 2012 reveal in temporal detail the return to the Jansky-level events observed in the 1970s. We compare these data to contemporaneous single-dish measurements at 4.8 and 8.5 GHz with the HartRAO 26-m telescope and X-ray monitoring from MAXI. We discuss whether the overall modulation and recent dramatic brightening is likely to be due to an increase in the power of the jet due to changes in accretion rate or changing Doppler boosting associated with a varying angle to the line of sight.Comment: 7 pages, 5 figures, accepted for publication in MNRAS 14 May 201

Geometric Finiteness, Holography and Quasinormal Modes for the Warped AdS_3 Black Hole

We show that there exists a precise kinematical notion of holography for the Euclidean warped $AdS_3$ black hole. This follows from the fact that the Euclidean warped $AdS_3$ black hole spacetime is a geometrically finite hyperbolic manifold. For such manifolds a theorem of Sullivan provides a one-to-one correspondence between the hyperbolic structure in the bulk and the conformal structure of its boundary. Using this theorem we obtain the holographic quasinormal modes for the warped $AdS_3$ black hole.Comment: Latex file, 7 pages. Journal versio

Can the polarization of the strange quarks in the proton be positive ?

Recently, the HERMES Collaboration at DESY, using a leading order QCD analysis of their data on semi-inclusive deep inelastic production of charged hadrons, reported a marginally positive polarization for the strange quarks in the proton. We argue that a non-negative polarization is almost impossible.Comment: 6 pages, latex, minor changes in the discussion after Eq. (9

A comparison of weak-turbulence and PIC simulations of weak electron-beam plasma interaction

Quasilinear theory has long been used to treat the problem of a weak electron beam interacting with plasma and generating Langmuir waves. Its extension to weak-turbulence theory treats resonant interactions of these Langmuir waves with other plasma wave modes, in particular ion-sound waves. These are strongly damped in plasma of equal ion and electron temperatures, as sometimes seen in, for example, the solar corona and wind. Weak turbulence theory is derived in the weak damping limit, with a term describing ion-sound wave damping then added. In this paper we use the EPOCH particle-in-cell code to numerically test weak turbulence theory for a range of electron-ion temperature ratios. We find that in the cold ion limit the results agree well, but increasing ion temperature the three-wave resonance becomes broadened in proportion to the ion-sound wave damping rate. This may be important in, for example, the theory of solar radio bursts, where the spectrum of Langmuir waves is critical. Additionally we establish lower limits on the number of simulation particles needed to accurately reproduce the electron and wave distributions in their saturated states, and to reproduce their intermediate states and time evolution.Comment: Accepted by PO