10 research outputs found
Healthy blue man: congenital methemoglobinemia
Congenital methemoglobinemia, though often discussed in medical teachings is rarely encountered in clinical practice as the condition is asymptomatic. Here we present such a case and discuss in detail the clinical presentation of both congenital and acquired methemoglobinemia. We also outlined the management of the conditions. One should suspect methemoglobinemia when cyanosis is not being corrected by supplementing oxygen and and when the oxygen saturation is low by pulse oximetry and normal by arterial blood gas analysis. Treatment modalities for congenital methemoglobinemia is of cosmetic purpose, but timely intervention in acquired methemoglobinemia could be lifesaving. Methylene blue, Ascorbic acid and Riboflavin are drugs of choice
Estimation of annual risk of tuberculosis infection (ARTI) among children aged 1–9 years in the south zone of India
OBJECTIVE: To estimate the annual risk of tuberculosis
infection (ARTI) among children aged 1–9 years in the
south zone of India.
SETTING: The survey was carried out in a representative
sample of villages and census enumeration blocks of
towns in four south Indian states, as a part of a nationwide
tuberculin survey.
DESIGN: Six districts were selected through systematic
random sampling. Four hundred and twenty rural clusters
and 180 urban clusters were selected from these districts
on the basis of the rural–urban ratio in the entire
zone. To obtain the required sample of 12 000 children
without bacille Calmette-Guérin (BCG) vaccination,
51 000 had to be covered. Eighty-five children from each
cluster were tuberculin tested and read for reaction sizes.
The ARTI was computed from the estimated prevalence
of TB infection among children without a BCG scar.
RESULT: Among 52 951 children registered for the
study, 50 846 (96%) had a tuberculin test result. The
BCG coverage for the study population was about 65%.
Among 17 811 children without a BCG scar, the prevalence
of infection was 5.9% (95%CI 4.0–7.7%); the corresponding
ARTI was 1.7% (95%CI 0.7–1.4%).
CONCLUSION: The estimated ARTI for the south zone
is 1.0%, as compared to the national average of 1.7%
used for programme evaluation. This baseline information
should be useful for the assessment of future trends