Non-clasical Nucleation in Supercooled Nickel

The dynamics of homogeneous nucleation and growth of crystalline nickel from the super-cooled melt is examined during rapid quenching using molecular dynamics and a modified embedded atom method potential. The character of the critical nuclei of the crystallization transition is examined using common neighbor analysis and visualization. At nucleation the saddle point droplet consists of randomly stacked planar structures with an in plane triangular order. These results are consistent with previous theoretical results that predict that the nucleation process in some metals is non-classical due to the presence of long-range forces and a spinodal.Comment: 4 pages, 5 figure

Probing the Parsec-scale Accretion Flow of 3C 84 with Millimeter Polarimetry

We report the discovery of Faraday rotation toward radio source 3C 84, the active galactic nucleus in NGC1275 at the core of the Perseus Cluster. The rotation measure (RM), determined from polarization observations at wavelengths of 1.3 and 0.9 mm, is (8.7 +/- 2.3) x 10^5 radians/m^2, among the largest ever measured. The RM remained relatively constant over a 2 year period even as the intrinsic polarization position angle wrapped through a span of 300 degrees. The Faraday rotation is likely to originate either in the boundary layer of the radio jet from the nucleus, or in the accretion flow onto the central black hole. The accretion flow probably is disk-like rather than spherical on scales of less than a parsec, otherwise the RM would be even larger.Comment: 7 pages, 3 figures, accepted for publication in Ap

The Submillimeter Polarization of Sgr A*

We report on the submillimeter properties of Sagittarius A* derived from observations with the Submillimeter Array and its polarimeter. We find that the spectrum of Sgr A* between 230 and 690 GHz is slightly decreasing when measured simultaneously, indicating a transition to optically thin emission around 300-400 GHz. We also present very sensitive and well calibrated measurements of the polarization of Sgr A* at 230 and 345 GHz. With these data we are able to show for the first time that the polarization of Sgr A* varies on hour timescales, as has been observed for the total intensity. On one night we find variability that may arise from a polarized "blob" orbiting the black hole. Finally, we use the ensemble of observations to determine the rotation measure. This represents the first statistically significant rotation measure determination and the only one made without resorting to comparing position angles measured at separate epochs. We find a rotation measure of (-5.6+/-0.7)x10^5 rad/m^2, with no evidence for variability on inter-day timescales at the level of the measurement error. The stability constrains interday fluctuations in the accretion rate to 8%. The mean intrinsic polarization position angle is 167+/-7 degrees and we detect variations of 31+18/-9 degrees. This separation of intrinsic polarization changes and possible rotation measure fluctuations is now possible because of the frequency coverage and sensitivity of our data. The observable rotation measure restricts the accretion rate to the range 2x10^{-7} Msun/yr to 2x10^{-9} Msun/yr, if the magnetic field is near equipartition and ordered.Comment: v2: Minor change to orbital calculation. Invited contribution to the proceedings of the Galactic Center Workshop 200

ALMA Observations of the Terahertz Spectrum of Sagittarius A*

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations at 233, 678, and 870 GHz of the Galactic Center black hole, Sagittarius A*. These observations reveal a flat spectrum over this frequency range with spectral index α ≈ −0.3, where the flux density S ∝ ν α . We model the submillimeter and far-infrared spectrum with a one-zone synchrotron model of thermal electrons. We infer electron densities n = (2–5) × 106 cm−3, electron temperatures T e = (1–3) × 1011 K, and magnetic field strength B = 10–50 G. The parameter range can be further constrained using the observed quiescent X-ray luminosity. The flat submillimeter spectrum results in a high electron temperature and implies that the emitting electrons are efficiently heated. We also find that the emission is most likely optically thin at 233 GHz. These results indicate that millimeter and submillimeter wavelength very long baseline interferometry of Sgr A* including those of the Event Horizon Telescope should see a transparent emission region down to event horizon scales.Alexander von Humboldt foundation; NWO VICI grant [639.043.513]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Millimeter Observations of the Type II SN2023ixf: Constraints on the Proximate Circumstellar Medium

We present 1.3 mm (230 GHz) observations of the recent and nearby Type II supernova, SN2023ixf, obtained with the Submillimeter Array (SMA) at 2.6-18.6 days after explosion. The observations were obtained as part the SMA Large Program POETS (Pursuit of Extragalactic Transients with the SMA). We do not detect any emission at the location of SN2023ixf, with the deepest limits of $L_\nu(230\,{\rm GHz})\lesssim 8.6\times 10^{25}$ erg s$^{-1}$ Hz$^{-1}$ at 2.7 and 7.7 days, and $L_\nu(230\,{\rm GHz})\lesssim 3.4\times 10^{25}$ erg s$^{-1}$ Hz$^{-1}$ at 18.6 days. These limits are about a factor of 2 times dimmer than the mm emission from SN2011dh (IIb), about an order of magnitude dimmer compared to SN1993J (IIb) and SN2018ivc (IIL), and about 30 times dimmer than the most luminous non-relativistic SNe in the mm-band (Type IIb/Ib/Ic). Using these limits in the context of analytical models that include synchrotron self-absorption and free-free absorption we place constraints on the proximate circumstellar medium around the progenitor star, to a scale of $\sim 2\times 10^{15}$ cm, excluding the range $\dot{M}\sim {\rm few}\times 10^{-6}-10^{-2}$ M$_\odot$ yr$^{-1}$ (for a wind velocity, $v_w=115$ km s$^{-1}$, and ejecta velocity, $v_{\rm eje}\sim (1-2)\times 10^4$ km s$^{-1}$). These results are consistent with an inference of the mass loss rate based on optical spectroscopy ($\sim 2\times 10^{-2}$ M$_\odot$ yr$^{-1}$ for $v_w=115$ km s$^{-1}$), but are in tension with the inference from hard X-rays ($\sim 7\times 10^{-4}$ M$_\odot$ yr$^{-1}$ for $v_w=115$ km s$^{-1}$). This tension may be alleviated by a non-homogeneous and confined CSM, consistent with results from high-resolution optical spectroscopy.Comment: Submitte

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD reporter transgene in naive mESCs correlated with lower levels of genomic DNA methylation, high expression of 5-methylcytosine hydroxylases Tet1/2 and low levels of DNA methyltransferases Dnmt3a/b. Moreover, naive mESCs, in which the BMP-SMAD reporter transgene was activated, showed higher resistance to differentiation. Using double Smad1;Smad5 knockout mESCs, we showed that BMP-SMAD signaling is dispensable for self-renewal in both naive and ground state. These mutant mESCs were still pluripotent, but they exhibited higher levels of DNA methylation than their wild-type counterparts and had a higher propensity to differentiate. We showed that BMP-SMAD signaling modulates lineage priming in mESCs, by transiently regulating the enzymatic machinery responsible for DNA methylation

Stability of cellular patterns in directional solidification

FWN – Publicaties zonder aanstelling Universiteit Leide

A Claudin-9–Based Ion Permeability Barrier Is Essential for Hearing

Hereditary hearing loss is one of the most common birth defects, yet the majority of genes required for audition is thought to remain unidentified. Ethylnitrosourea (ENU)–mutagenesis has been a valuable approach for generating new animal models of deafness and discovering previously unrecognized gene functions. Here we report on the characterization of a new ENU–induced mouse mutant (nmf329) that exhibits recessively inherited deafness. We found a widespread loss of sensory hair cells in the hearing organs of nmf329 mice after the second week of life. Positional cloning revealed that the nmf329 strain carries a missense mutation in the claudin-9 gene, which encodes a tight junction protein with unknown biological function. In an epithelial cell line, heterologous expression of wild-type claudin-9 reduced the paracellular permeability to Na+ and K+, and the nmf329 mutation eliminated this ion barrier function without affecting the plasma membrane localization of claudin-9. In the nmf329 mouse line, the perilymphatic K+ concentration was found to be elevated, suggesting that the cochlear tight junctions were dysfunctional. Furthermore, the hair-cell loss in the claudin-9–defective cochlea was rescued in vitro when the explanted hearing organs were cultured in a low-K+ milieu and in vivo when the endocochlear K+-driving force was diminished by deletion of the pou3f4 gene. Overall, our data indicate that claudin-9 is required for the preservation of sensory cells in the hearing organ because claudin-9–defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph. In the tight-junction complexes of hair cells, claudin-9 is localized specifically to a subdomain that is underneath more apical tight-junction strands formed by other claudins. Thus, the analysis of claudin-9 mutant mice suggests that even the deeper (subapical) tight-junction strands have biologically important ion barrier function