Aneurysmal bone cyst in proximal phalanx treated without bone grafting

Aneurysmal bone cyst involving the hand are a rare occurrence especially in the proximal phalanx. We report a case of 5 years old female child with proximal phalanx aneurysmal bone cyst treated without bone grafting. Magnetic resonance imaging may show fluid filled spaces but definite diagnosis can only be obtained histologically. It is a benign lesion still it can involve growth plate hence intervention is necessary. The treatment includes curettage with or without bone grafting

Design and Implementation of Modified P&O Algorithm for Industrial Waste Heat Recovery System Using Thermoelectric Module

This paper proposes a novel Maximum Power Point Tracking (MPPT) control method of thermoelectric power generation for the constant load. This paper reveals the characteristics and the internal resistance of thermoelectric power module (TM). To control the operating point & to extract the maximum power from waste heat using TEG is essential as there is a wastage of heat from Industries, automobiles etc. To fix maximum power point from waste heat, a good number of algorithms has been proposed, one of them is P&O algorithm. Analyzing the thermoelectric power generation system with boost chopper by P&O Method, the output voltage and current of TM are estimated by with only single current sensor. The basic principle of the proposed MPPT control method is discussed, and then confirmed by digital computer simulation using Matlab. Simulation results demonstrate that the output voltage can track the maximum power point voltage by the proposed MPPT control method. The comparative analysis between P&O and modified Perturb & Observe (P&O) algorithm for extracting the power from thermoelectric array TM is analyzed briefly below

Analysis, Design and Experimental Validation of Modified Simple Soft Switching DC-DC Boost Converter

This paper investigates a modified simple soft switching dc-dc converter for low power applications. This simple topology uses an auxiliary switch, an inductor and a capacitor to operate the converter without switching losses. The efficiency of the converter is improved by transferring the energy that would be dissipated during the switching to the load. The main switch turns-on with zero current switching (ZCS) and turns-off with zero voltage switching (ZVS), while the auxiliary switch turns-on and turns-off with zero voltage switching (ZVS). The detailed theoretical analysis and the design equations are described. In addition to that, the analysis of proposed converter is demonstrated by both simulation and experimental results for effectiveness of the study.Web of Science16433733

Biocompatibility and Toxicity of Poly(vinyl alcohol)/N,O-Carboxymethyl Chitosan Scaffold

The in vivo biocompatibility and toxicity of PVA/NOCC scaffold were tested by comparing them with those of a biocompatible inert material HAM in a rat model. On Day 5, changes in the blood parameters of the PVA/NOCC-implanted rats were significantly higher than those of the control. The levels of potassium, creatinine, total protein, A/G, hemoglobulin, erythrocytes, WBC, and platelets were not significantly altered in the HAM-implanted rats, when compared with those in the control. On Day 10, an increase in potassium, urea, and GGT levels and a decrease in ALP, platelet, and eosinophil levels were noted in the PVA/NOCC-implanted rats, when compared with control. These changes were almost similar to those noted in the HAM-implanted rats, except for the unaltered potassium and increased neutrophil levels. On Day 15, the total protein, A/G, lymphocyte, monocyte, and eosinophil levels remained unaltered in the PVA/NOCC-implanted rats, whereas urea, A/G, WBC, lymphocyte, and monocyte levels remained unchanged in the HAM-implanted rats. Histology and immunohistochemistry analyses revealed inflammatory infiltration in the PVA/NOCC-implanted rats, but not in the HAM-implanted rats. Although a low toxic tissue response was observed in the PVA/NOCC-implanted rats, further studies are necessary to justify the use of this material in tissue engineering applications

Projective Ring Line Encompassing Two-Qubits

The projective line over the (non-commutative) ring of two-by-two matrices with coefficients in GF(2) is found to fully accommodate the algebra of 15 operators - generalized Pauli matrices - characterizing two-qubit systems. The relevant sub-configuration consists of 15 points each of which is either simultaneously distant or simultaneously neighbor to (any) two given distant points of the line. The operators can be identified with the points in such a one-to-one manner that their commutation relations are exactly reproduced by the underlying geometry of the points, with the ring geometrical notions of neighbor/distant answering, respectively, to the operational ones of commuting/non-commuting. This remarkable configuration can be viewed in two principally different ways accounting, respectively, for the basic 9+6 and 10+5 factorizations of the algebra of the observables. First, as a disjoint union of the projective line over GF(2) x GF(2) (the "Mermin" part) and two lines over GF(4) passing through the two selected points, the latter omitted. Second, as the generalized quadrangle of order two, with its ovoids and/or spreads standing for (maximum) sets of five mutually non-commuting operators and/or groups of five maximally commuting subsets of three operators each. These findings open up rather unexpected vistas for an algebraic geometrical modelling of finite-dimensional quantum systems and give their numerous applications a wholly new perspective.Comment: 8 pages, three tables; Version 2 - a few typos and one discrepancy corrected; Version 3: substantial extension of the paper - two-qubits are generalized quadrangles of order two; Version 4: self-dual picture completed; Version 5: intriguing triality found -- three kinds of geometric hyperplanes within GQ and three distinguished subsets of Pauli operator

Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways

Parasitic nematodes cause significant morbidity and mortality globally. Excretory/secretory products (ESPs) such as fatty acid- and retinol- binding proteins (FARs) are hypothesized to suppress host immunity during nematode infection, yet little is known about their interactions with host tissues. Leveraging the insect parasitic nematode, Steinernema carpocapsae, we describe here the first in vivo study demonstrating that FARs modulate animal immunity, causing an increase in susceptibility to bacterial co-infection. Moreover, we show that FARs dampen key components of the fly immune response including the phenoloxidase cascade and antimicrobial peptide (AMP) production. Our data also reveal that FARs deplete lipid signaling precursors in vivo as well as bind to these fatty acids in vitro, suggesting that FARs elicit their immunomodulatory effects by altering the availability of lipid signaling molecules necessary for an efficient immune response. Collectively, these data support a complex role for FARs in immunosuppression in animals and provide detailed mechanistic insight into parasitism in phylum Nematoda

Incidence of seed migration to the chest, abdomen, and pelvis after transperineal interstitial prostate brachytherapy with loose 125I seeds

<p>Abstract</p> <p>Background</p> <p>The aim was to determine the incidence of seed migration not only to the chest, but also to the abdomen and pelvis after transperineal interstitial prostate brachytherapy with loose ¹²⁵I seeds.</p> <p>Methods</p> <p>We reviewed the records of 267 patients who underwent prostate brachytherapy with loose ¹²⁵I seeds. After seed implantation, orthogonal chest radiographs, an abdominal radiograph, and a pelvic radiograph were undertaken routinely to document the occurrence and sites of seed migration. The incidence of seed migration to the chest, abdomen, and pelvis was calculated. All patients who had seed migration to the abdomen and pelvis subsequently underwent a computed tomography scan to identify the exact location of the migrated seeds. Postimplant dosimetric analysis was undertaken, and dosimetric results were compared between patients with and without seed migration.</p> <p>Results</p> <p>A total of 19,236 seeds were implanted in 267 patients. Overall, 91 of 19,236 (0.47%) seeds migrated in 66 of 267 (24.7%) patients. Sixty-nine (0.36%) seeds migrated to the chest in 54 (20.2%) patients. Seven (0.036%) seeds migrated to the abdomen in six (2.2%) patients. Fifteen (0.078%) seeds migrated to the pelvis in 15 (5.6%) patients. Seed migration occurred predominantly within two weeks after seed implantation. None of the 66 patients had symptoms related to the migrated seeds. Postimplant prostate D90 was not significantly different between patients with and without seed migration.</p> <p>Conclusion</p> <p>We showed the incidence of seed migration to the chest, abdomen and pelvis. Seed migration did not have a significant effect on postimplant prostate D90.</p

Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome.

BACKGROUND: The loss of alveolar epithelial and endothelial integrity is a central component in acute respiratory distress syndrome (ARDS); however, experimental models investigating the mechanisms of epithelial injury are lacking. The purpose of the present study was to design and develop an experimental porcine model of ARDS by inducing lung injury with intrapulmonary administration of sodium polyacrylate (SPA). METHODS: The present study was performed at the Centre for Comparative Medicine, University of British Columbia, Vancouver, British Columbia. Human alveolar epithelial cells were cultured with several different concentrations of SPA; a bioluminescence technique was used to assess cell death associated with each concentration. In the anesthetized pig model (female Yorkshire X pigs (n = 14)), lung injury was caused in 11 animals (SPA group) by injecting sequential aliquots (5 mL) of 1% SPA gel in aqueous solution into the distal airway via a rubber catheter through an endotracheal tube. The SPA was dispersed throughout the lungs by manual bag ventilation. Three control animals (CON group) underwent all experimental procedures and measurements with the exception of SPA administration. RESULTS: The mean (± SD) ATP concentration after incubation of human alveolar epithelial cells with 0.1% SPA (0.92 ± 0.27 μM/well) was approximately 15% of the value found for the background control (6.30 ± 0.37 μM/well; p < 0.001). Elastance of the respiratory system (E RS) and the lung (E L) increased in SPA-treated animals after injury (p = 0.003 and p < 0.001, respectively). Chest wall elastance (E CW) did not change in SPA-treated animals. There were no differences in E RS, E L, or E CW in the CON group when pre- and post-injury values were compared. Analysis of bronchoalveolar lavage fluid showed a significant shift toward neutrophil predominance from before to after injury in SPA-treated animals (p < 0.001) but not in the CON group (p = 0.38). Necropsy revealed marked consolidation and congestion of the dorsal lung lobes in SPA-treated animals, with light-microscopy evidence of bronchiolar and alveolar spaces filled with neutrophilic infiltrate, proteinaceous debris, and fibrin deposition. These findings were absent in animals in the CON group. Electron microscopy of lung tissue from SPA-treated animals revealed injury to the alveolar epithelium and basement membranes, including intra-alveolar neutrophils and fibrin on the alveolar surface and intravascular fibrin (microthrombosis). CONCLUSIONS: In this particular porcine model, the nonimmunogenic polymer SPA caused a rapid exudative lung injury. This model may be useful to study ARDS caused by epithelial injury and inflammation