Caracterização física, química e sensorial de um salgado hiperproteico consumido por atletas e praticantes de atividade física

Como uma alternativa aos suplementos proteicos, muitos atletas e praticantes de atividade física têm consumido um salgado que tem sido amplamente divulgado através de redes sociais na internet. A versão mais popular do salgado tem sido a de massa elaborada com carne de peito de frango e couve-flor. Porém, a relação entre carne de frango e couve-flor tem variado e até o presente momento nenhum estudo foi desenvolvido para caracterização desse salgado. Assim, o objetivo do presente trabalho foi avaliar física, química e sensorialmente formulações (F) do salgado elaboradas com diferentes percentuais de couve-flor (F1 - 33% e F2 - 47%). Na avaliação física, foram determinados os valores médios de peso, volume aparente, volume específico e fator térmico. A composição química das amostras procedeu-se de acordo com os métodos oficiais. O pH, acidez titulável e valor energético também foram determinados. Na análise sensorial, 50 provadores não treinados, de ambos os sexos, realizaram em prova aberta o teste sensorial afetivo de escala hedônica de 9 pontos. A aceitabilidade das amostras foi avaliada quanto ao aspecto geral e atributos cor, aroma, sabor e textura. Os resultados obtidos mostraram que a relação entre carne de frango e couve-flor levou a uma diminuição significativa no peso da formulação F2 antes e após a cocção, bem como no volume aparente e fator térmico. O teor de proteínas da formulação F2 também foi significativamente mais baixo. Contudo, na avaliação sensorial, ambas as formulações obtiveram índice de aceitabilidade acima de 70% para todos os atributos sensoriais avaliados. ABSTRACTPhysical, Chemical and Sensory Characterization of a Hyperproteic Snack Eaten by Athletes and Physical Activity PractitionersAs an alternative to protein supplements, athletes and physical activity practitioners have consumed a snack that has been widely disseminated through social networks on the internet.  Its most popular version has been that of dough produced with chicken breast and cauliflower. However, the relation between both ingredients has varied and so far no study has been developed to characterize this snack. The aim of this study was to evaluate physical, chemical and sensorial two formulations (F) of the snack (F1 - 33% e F2 - 47%). On the physical evaluation, the mean values of weight, apparent volume, specific volume and thermal factor were determined. The chemical composition of the samples was carried out in accordance with the official methods. The values of pH, titratable acidity and energy were also determined. In the sensory evaluation, 50 untrained panelist, of both sexes, held in an open assay the affective sensory test of a nine-point hedonic scale ranging from 1 = dislike extremely to 9 = like extremely. The acceptability of the samples was evaluated for general appearance and the attributes color, aroma, flavor and texture. The results obtained showed that the relation between chicken meat and cauliflower led to a significant decrease in the weight of the formulation F2 before and after cooking, as well as in the apparent volume and heat factor. The protein content of formulation F2 was also significantly lower. However, in the sensory evaluation, both formulations showed acceptability index above 70% for all sensory attributes evaluated

Food security:reflections on a complex problem

RESUMO. O combate à má alimentação em todas as suas formas, que também se expressa na epidemia da obesidade, é uma das prioridades da Agenda 2030 e dos Objetivos de Desenvolvimento Sustentável. Este artigo traz elementos sobre insegurança alimentar no Brasil, a partir de temas relativos ao crescimento populacional, mudanças climáticas, biodiversidade e sistemas alimentares tradicionais e regenerativos; trata também do papel dos movimentos sociais para a garantia do Direito Humano à Alimentação Adequada. O Grupo de Pesquisa em Nutrição e Pobreza, o Saúde Planetária Brasil, e o Centro de Inteligência Artificial (C4AI) - Eixo AgriBio, entendem que a retomada organizada e sistêmica das frentes apontadas neste artigo de posicionamento, pode constituir um caminho para a articulação entre pesquisa, serviço e políticas públicas na direção do combate à fome e às demais manifestações da má alimentação, enquanto problema complexo prioritário para a garantia do bem-estar social

CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION

Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy.Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy

A RELAÇÃO ENTRE A ENDOMETRIOSE E A INFERTILIDADE FEMININA

  Endometriosis and female infertility are interconnected in complex ways. Infertility is defined as the inability to conceive after twelve months of regular sexual intercourse, and endometriosis, an estrogen-dependent condition, has a well-established association with difficulty conceiving. Although the exact cause and cause-and-effect relationship remain controversial, endometriosis affects fertility in several ways. Peritoneal lesions, ovarian endometrioma and deep endometriosis negatively influence reproductive health, which can lead to anatomical distortions, endocrine and immunological dysfunctions. Identify the factors of endometriosis that affect female infertility. Data collection was conducted through the following databases: Nursing Database (BDENF), Scientific Electronic Library Online (SCIELO), PubMed, Latin American Caribbean Literature in Health Sciences (LILACS). Various types of publications were consulted, including scientific articles, monographs and magazines, with the aim of obtaining relevant information on the topic. The results revealed a substantial correlation between the severity of endometriosis and infertility rates, highlighting the importance of early detection and appropriate management. Additionally, therapeutic interventions such as laparoscopic surgeries and IVF treatments have been associated with improvements in conception rates. The discussion emphasizes the need for multidisciplinary approaches, integrating gynecology and assisted reproduction, to optimize reproductive results in women with endometriosis. In summary, endometriosis presents itself as a significant factor in the occurrence of female infertility, negatively impacting conception. Understanding this relationship is crucial to guide clinical approaches and treatment strategies, aiming to improve the chances of pregnancy in women affected by this condition.A endometriose e a infertilidade feminina estão interligadas de maneira complexa. A infertilidade é definida como a incapacidade de conceber após doze meses de relações sexuais regulares, e a endometriose, uma condição estrogênio-dependente, apresenta associação bem estabelecida com a dificuldade de engravidar. Embora a causa exata e a relação de causa e efeito permaneçam controversas, a endometriose afeta a fertilidade de várias maneiras. Lesões peritoneais, ovário endometrioma e endometriose profunda influenciam negativamente na saúde reprodutiva, podendo levar a distorções anatômicas, disfunções endócrinas e imunológica. Identificar os fatores da endometriose com o acometimento da infertilidade feminina. A coleta de dados, esta foi conduzida por meio dos bancos de dados: Base de Dados em Enfermagem (BDENF), Scientific Electronic Library Online (SCIELO), PubMed, Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS). Foram consultados diversos tipos de publicações, incluindo artigos científicos, monografias e revistas, com o objetivo de obter informações relevantes sobre o tema. Os resultados revelaram uma correlação substancial entre a gravidade da endometriose e as taxas de infertilidade, destacando a importância da detecção precoce e do manejo adequado. Além disso, intervenções terapêuticas, como cirurgias laparoscópicas e tratamentos de fertilização in vitro, foram associadas a melhorias nas taxas de concepção. A discussão enfatiza a necessidade de abordagens multidisciplinares, integrando a ginecologia e a reprodução assistida, para otimizar os resultados reprodutivos em mulheres com endometriose. Em síntese, a endometriose apresenta-se como um fator significativo na ocorrência de infertilidade feminina, impactando negativamente a concepção. A compreensão dessa relação é crucial para orientar abordagens clínicas e estratégias de tratamento, visando melhorar as chances de gestação em mulheres afetadas por essa condição

Avanços na abordagem terapêutica da insuficiência cardíaca com fração de ejeção preservada (ICFEP): O uso de inibidores de SGLT-2

A insuficiência cardíaca (IC) com fração de ejeção preservada (ICFEP) é a forma mais prevalente de IC em pacientes com mais de 65 anos e representa mais de 50% dos casos prevalentes de IC na população. As intervenções terapêuticas da ICFEP ainda estão sendo exploradas e pesquisadas, como o uso de inibidores de SGLT-2. O presente estudo de revisão buscou avaliar novos avanços na abordagem terapêutica da insuficiência cardíaca com fração de ejeção preservada (ICFEP) a partir do uso de inibidores de SGLT-2, documentados por meio de estudos clínicos e randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos e testes controlados e aleatórios; artigos publicados no último ano; que possuíam texto completo disponível e que abordassem acerca do uso de inibidores de SGLT-2 na ICFEP. Ficou constatado que a dapagliflozina resultou em melhora dos sintomas relacionados à insuficiência cardíaca e limitações físicas nesses pacientes, bem como a canagliflozina, a qual trouxe resultados de melhora rápida e clinicamente significativa dos sintomas de IC. Já a empagliflozina demonstrou uma redução significativa no risco de morte cardiovascular ou hospitalizações por insuficiência cardíaca. Por fim, verificou-se que a ipragliflozina pode contribuir, em determinados subgrupos, reduzindo o índice de massa ventricular esquerda e, ainda, uma redução dos níveis de NT-proBNP, um marcador de disfunção ventricular. Dessa forma, os inibidores de SGLT-2 se fazem importantes medicações para a terapêutica efetiva da ICFEP atualmente

Tendências Atuais na Eficácia e Mecanismos de Ação: Uma Revisão Sistemática sobre o Uso de Análogos de GLP-1 no Tratamento da Obesidade

This work presents a systematic review on current trends in the effectiveness and mechanisms of action of GLP-1 analogs in the treatment of obesity. The introduction highlights the growing prevalence of obesity as a global public health challenge, positioning GLP-1 analogs as a promising approach. The methodology describes the formulation of the research question, study selection criteria, data extraction, and the analysis of study quality. The results emphasize the efficacy of these analogs in weight reduction, explore the neurobiological mechanisms involved, and demonstrate improvements in obesity-related comorbidities. The conclusion underscores the consistency of the reviewed evidence and the need for further research to optimize personalized therapeutic approaches.Este trabalho apresenta uma revisão sistemática sobre as tendências atuais na eficácia e nos mecanismos de ação dos análogos de GLP-1 no tratamento da obesidade. A introdução destaca a crescente prevalência da obesidade como um desafio global de saúde pública, situando os análogos de GLP-1 como uma abordagem promissora. A metodologia descreve a formulação da pergunta de pesquisa, os critérios de seleção de estudos, a extração de dados e a análise da qualidade dos estudos. Os resultados destacam a eficácia desses análogos na redução de peso, exploram os mecanismos neurobiológicos envolvidos e evidenciam melhorias nas comorbidades associadas à obesidade. A conclusão ressalta a consistência da evidência revisada e a necessidade de pesquisas adicionais para otimizar abordagens terapêuticas personalizadas

Applications of platelet- and leukocyte-rich fibrin (L-PRF) in Oral and Maxillofacial Surgery

Introduction: Oral and maxillofacial surgery plays a crucial role in the reconstruction and restoration of facial structures, seeking to improve both aesthetics and function. The use of platelet-rich fibrin (L-PRF) represents a notable advance, accelerating healing and improving surgical outcomes. Materials and Methods: This review covers 710 studies from various electronic databases (PubMed, Scopus, Web of Science, Science Direct and Google Scholar). The aim is to thoroughly investigate the applications of platelet- and leukocyte-rich fibrin (L-PRF) in Oral and Maxillofacial Surgery and Traumatology. Results: The analysis reveals that L-PRF stands out as an effective autologous therapy in oral and maxillofacial surgery. Its application shows remarkable potential for accelerating the healing process, contributing significantly to the effectiveness of procedures. Discussion: L-PRF has emerged as an excellent choice in oral and maxillofacial surgery and traumatology, improving both the aesthetic and functional aspects of facial reconstructions. This highlights the relevance of this autologous therapy and its benefits in surgical practice. Conclusion: The applications of platelet and leukocyte-rich fibrin (L-PRF) in Oral and Maxillofacial Surgery and Traumatology are fundamental and promising. This advance represents not only a means of accelerating healing, but also a significant contribution to better aesthetic and functional results in surgical procedures in this area.Introduction: Oral and maxillofacial surgery plays a crucial role in the reconstruction and restoration of facial structures, seeking to improve both aesthetics and function. The use of platelet-rich fibrin (L-PRF) represents a notable advance, accelerating healing and improving surgical outcomes. Materials and Methods: This review covers 710 studies from various electronic databases (PubMed, Scopus, Web of Science, Science Direct and Google Scholar). The aim is to thoroughly investigate the applications of platelet- and leukocyte-rich fibrin (L-PRF) in Oral and Maxillofacial Surgery and Traumatology. Results: The analysis reveals that L-PRF stands out as an effective autologous therapy in oral and maxillofacial surgery. Its application shows remarkable potential for accelerating the healing process, contributing significantly to the effectiveness of procedures. Discussion: L-PRF has emerged as an excellent choice in oral and maxillofacial surgery and traumatology, improving both the aesthetic and functional aspects of facial reconstructions. This highlights the relevance of this autologous therapy and its benefits in surgical practice. Conclusion: The applications of platelet and leukocyte-rich fibrin (L-PRF) in Oral and Maxillofacial Surgery and Traumatology are fundamental and promising. This advance represents not only a means of accelerating healing, but also a significant contribution to better aesthetic and functional results in surgical procedures in this area

2 nd Brazilian Consensus on Chagas Disease, 2015

Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research