Management of acute myeloid leukemia in Covid 19 era

The covid 19 pandemic has not spared patients with hematological malignancies. The hematologist community faces unprecedented challenge since the first identification of this new virus .in this study, we aim to describe characteristics and outcome of patients with acute myeloid leukemia (AML) diagnosed with covid 19 infection at different states of the disease.A total of 16 COVID-19-infected patients with AML were included; 4 (25%) patients were male. Median age was 37 years. 7 patients had a favorable, 7 intermediate and 2 high risk AML. we noted no case of hemorrhagic syndrome and only 1 patient developed a deep vein thrombosis. treatment of AML was postponed in 11 patients. 4 patients attracted SARS-COV2 infection undergoing intensive myelosuppressive chemotherapy. 2 patients had severe events and only 1 patient died. Patients with AML may show favorable outcomes of COVID 19 infection even while treated with intensive chemotherapy. Coronavirus disease has change life overnight and impact the management of patients suffering from cancer in general and particularly patients with AML, we need more studies to better understand different aspects of this tiny microorganism and its impact on the management of these patients

A rare cause of acute esophageal necrosis: A case report

Acute esophageal necrosis (AEN) or black esophagus is a rare entity characterized by diffuse circumferential black pigmentation of the esophageal mucosa due to ischemic necrosis. It may be lethal, especially among elderly patients with multiple comorbidities and hemodynamic instability. Diagnosis is based on gastroscopy. Treatment consists of intravenous fluids, proton pump inhibitors, and additional therapies to treat the underlying illness. We report a rare case of a woman in her 50s with cervical cancer who presented with hematemesis and sepsis. Upper gastrointestinal endoscopy showed a black esophagus and an ulcerobudding duodenal process. Few days later, she developed abdominal distension with diffuse pain. Abdominal CT scan demonstrated perforation of gastroduodenal tumor. The treatment was based on resuscitation, proton pump inhibitors, antibiotics, and surgery of the perforated tumor. Unfortunately, the patient died 2 days later because of septic shock. The black esophagus is a fatal complication, thus diagnosis at an early stage and timely management may improve survival. This is the first case reported of AEN due to perforated duodenal tumor explained by septic shock leading to an ischemic esophageal injury

Probabilistic tsunami hazard assessment along Oman coast from submarine earthquakes in the Makran subduction zone

The Sultanate of Oman is among the Indian Ocean countries that were subjected to at least two confirmed tsunamis during the twentieth and twenty-first centuries: the 1945 tsunami due to an earthquake in the Makran subduction zone in the Sea of Oman (near-regional field tsunami) and the Indian-Ocean tsunami in 2004, caused by an earthquake from the Andaman Sumatra subduction zone (far - field tsunami). In this paper, we present a probabilistic tsunami hazard assessment for the entire coast of Oman from tectonic sources generated along the Makran subduction zone. The tsunami hazard is assessed taking into account the contribution of small-and large-event magnitudes. Results of the earthquake recurrence rate studies and the tsunami numerical modeling for different magnitudes were used through a logic-tree to estimate the tsunami hazard probabilities. We derive probability hazard exceedance maps for the Omani coast considering the exposure times of 100, 250, 500, and 1000 years. The hazard maps consist of computing the likelihood that tsunami waves exceed a specific amplitude. We find that the probability that a maximum wave amplitude exceeds 1 m somewhere along the coast of Oman reaches, respectively, 0.7 and 0.85 for 100 and 250 exposure times, and it is up to 1 for 500 and 1000 years of exposure times. These probability values decrease significantly toward the southern coast of Oman where the tsunami impact, from the earthquakes generated at Makran subduction zone, is low.info:eu-repo/semantics/publishedVersio

Tsunami hazard assessment along Diba-Oman and Diba-Al-Emirates coasts

Tsunami is among the most devastating natural hazards phenomenon responsible for significant loss of life and property throughout history. The Sultanate of Oman and United Arab Emirates are among the Indian Ocean countries that were subjected to one confirmed tsunami in November 27, 1945 due to an Mw 8.1 earthquake in Makran Subduction Zone. In this study, we present preliminary deterministic tsunami hazard assessment for the coasts of Diba Oman and Diba Al-Emirates, which are located on the western coast of the Oman Sea. The tsunami vulnerability of these cities increases due to the construction of many critical infrastructures and urban concentration along their coasts. Therefore, tsunami hazard assessment is necessary to mitigate the risk on the socio-economic system and sustainable developments. The major known source of tsunamis able to impact both coasts of Oman and United Arab Emirates is the Makran Subduction Zone (MSZ) which extends for approximately 900 km. The deterministic approach uses specific scenarios considering the maximum credible earthquakes occurring in the MSZ and computes the ensuing tsunami impact in the coasts of the study area. The maximum wave height graphs and inundation maps are obtained for tsunami scenarios caused by 8.8 earthquake magnitude in eastern MSZ and 8.2 magnitude from western MSZ. The Mw8.8 eastern MSZ causes a maximum inundation distance of 447 meters and a maximum flow depth of 1.37 meter. Maximum inundation distance larger than 420 meters occurs due to the Mw8.2 western MSZ scenario. For this scenario, numerical simulations show a maximum flow depth of about 2.34 meters