Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

It is usually considered that larger brains have larger neurons, which consume more energy individually, and are therefore accompanied by a larger number of glial cells per neuron. These notions, however, have never been tested. Based on glucose and oxygen metabolic rates in awake animals and their recently determined numbers of neurons, here I show that, contrary to the expected, the estimated glucose use per neuron is remarkably constant, varying only by 40% across the six species of rodents and primates (including humans). The estimated average glucose use per neuron does not correlate with neuronal density in any structure. This suggests that the energy budget of the whole brain per neuron is fixed across species and brain sizes, such that total glucose use by the brain as a whole, by the cerebral cortex and also by the cerebellum alone are linear functions of the number of neurons in the structures across the species (although the average glucose consumption per neuron is at least 10× higher in the cerebral cortex than in the cerebellum). These results indicate that the apparently remarkable use in humans of 20% of the whole body energy budget by a brain that represents only 2% of body mass is explained simply by its large number of neurons. Because synaptic activity is considered the major determinant of metabolic cost, a conserved energy budget per neuron has several profound implications for synaptic homeostasis and the regulation of firing rates, synaptic plasticity, brain imaging, pathologies, and for brain scaling in evolution

[Social medical themes and the health intervention: violence against women in the professional's discourse].

This study deals with violence against women as a health care matter. It was part of a research in public services of São Paulo (Brazil), including the prevalence of violence among users from 15 to 49 years old; the study of their medical records; the description of the services; and interview with 50 professionals, focusing the routine and the ideals of health work, the perception on the existence of violence cases, the offer of assistance or its obstacles and the representations on violence. This article analyses the content of the professional narratives and uses the other data to characterise the assistance context. Confirming the literature, violence was almost always regarded as a relevant problem but outside the professional's intervention boundaries. Isolated actions and in a personal basis were reported. Fear and professional impotence were mentioned, but none positive aspect for potential interventions. The professionals showed lack of knowledge of specialized reference services. In conclusion, the difficulties in the acceptance of violence cases should be worked in three dimensions: the narrow definition of professionals' competence that excludes violence as an object; the absence of technological definitions for professional actions; and effective support in their services

Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury

Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, and to test candidate therapies before they are applied to human patients. The lesion model consists of a lateral spinal cord hemisection at the C7 spinal level with subsequent examination of behavioral, electrophysiological, and anatomical outcomes. Results to date have revealed significant neuroanatomical and functional differences between rodents and primates that impact the development of candidate therapies. Moreover, these findings suggest the importance of testing some therapeutic approaches in nonhuman primates prior to the use of invasive approaches in human clinical trials. Our primate model is intended to: 1) lend greater positive predictive value to human translatable therapies, 2) develop appropriate methods for human translation, 3) lead to basic discoveries that might not be identified in rodent models and are relevant to human translation, and 4) identify new avenues of basic research to “reverse-translate” important questions back to rodent model