The effect of mindful eating on subsequent intake of a high calorie snack

This study examined the effects of applying a mindful eating strategy during lunch on subsequent intake of a palatable snack. It also looked at whether this effect occurred due to improved memory for lunch and whether effects varied with participant gender, level of interoceptive awareness or sensitivity to reward. Participants (n = 51) completed a heartbeat perception task to assess interoceptive awareness. They were then provided with a lunch of 825 calories. Participants in the experimental group ate lunch while listening to an audio clip encouraging them to focus on the sensory properties of the food (e.g. its smell, look, texture). Those in the control group ate lunch in silence. Two hours later participants were offered a snack. They then completed a questionnaire assessing sensitivity to reward as well as other measures assessing various aspects of their memory for lunch. The results showed no significant difference in lunch intake between the two groups but participants in the experimental group consumed significantly less snack than those in the control group; mean = 112.30 calories (SD = 70.24) versus mean = 203.20 calories (SD = 88.05) respectively, Cohen's d = 1.14. This effect occurred regardless of participant gender or level of interoceptive awareness. There was also no significant moderation by sensitivity to reward although one aspect, reward interest, showed a trend towards significance. There was no evidence to indicate that the mindful eating strategy enhanced participants' memory for their lunch. Further research is needed to assess the long-term effects of this strategy, as well as establish the underlying mechanisms. Future work on the relationship between sensitivity to reward and the effects of mindful eating may also benefit from larger sample sizes

Impacts of the Primary School Free Breakfast Initiative on socio-economic inequalities in breakfast consumption among 9–11-year-old schoolchildren in Wales

Objectives - Universal interventions may widen or narrow inequalities if disproportionately effective among higher or lower socio-economic groups. The present paper examines impacts of the Primary School Free Breakfast Initiative in Wales on inequalities in children's dietary behaviours and cognitive functioning.<p></p> Design Cluster - randomised controlled trial. Responses were linked to free school meal (FSM) entitlement via the Secure Anonymised Information Linkage databank. Impacts on inequalities were evaluated using weighted school-level regression models with interaction terms for intervention × whole-school percentage FSM entitlement and intervention × aggregated individual FSM entitlement. Individual-level regression models included interaction terms for intervention × individual FSM entitlement.<p></p> Setting - Fifty-five intervention and fifty-six wait-list control primary schools.<p></p> Subjects - Approximately 4500 children completed measures of dietary behaviours and cognitive tests at baseline and 12-month follow-up.<p></p> Results School-level models indicated that children in intervention schools ate a greater number of healthy items for breakfast than children in control schools (b = 0·25; 95 % CI 0·07, 0·44), with larger increases observed in more deprived schools (interaction term b = 1·76; 95 % CI 0·36, 3·16). An interaction between intervention and household-level deprivation was not significant. Despite no main effects on breakfast skipping, a significant interaction was observed, indicating declines in breakfast skipping in more deprived schools (interaction term b = −0·07; 95 % CI −0·15, −0·00) and households (OR = 0·67; 95 % CI 0·46, 0·98). No significant influence on inequality was observed for the remaining outcomes.<p></p> Conclusions - Universal breakfast provision may reduce socio-economic inequalities in consumption of healthy breakfast items and breakfast skipping. There was no evidence of intervention-generated inequalities in any outcomes

The pharmacology and function of receptors for short-chain fatty acids

Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry. One way that this issue might be addressed is via translation of recent deorphanization programs that have opened the prospect of extending the reach of new medicine design to novel receptor types with potential therapeutic value. Prominent among these receptors are those that respond to short-chain free fatty acids of carbon chain length 2–6. These receptors, FFA2 (GPR43) and FFA3 (GPR41), are each predominantly activated by the short-chain fatty acids acetate, propionate, and butyrate, ligands that originate largely as fermentation by-products of anaerobic bacteria in the gut. However, the presence of FFA2 and FFA3 on pancreatic β-cells, FFA3 on neurons, and FFA2 on leukocytes and adipocytes means that the biologic role of these receptors likely extends beyond the widely accepted role of regulating peptide hormone release from enteroendocrine cells in the gut. Here, we review the physiologic roles of FFA2 and FFA3, the recent development and use of receptor-selective pharmacological tool compounds and genetic models available to study these receptors, and present evidence of the potential therapeutic value of targeting this emerging receptor pair

The effect of organic farming systems on aspects of the environment - desk study OF0123

Key Conclusions 1. The crop rotations of organic systems maintain landscape diversity and biodiversity whilst the maintenance of field boundaries on organic units produces benefits to a wide range of organisms. 2. Inorganic nitrogen fertilisation and herbicide treatments of conventionally managed grassland has reduced the floral diversity of permanent pastures and maintained the low diversity of re-seeded pastures, greatly reducing their value as wildlife habitats. 3. Pesticide use is responsible for the removal of food sourcesfor birds and mammals in the form of weeds and invertebrates, as well as removing whole populations of potentially beneficial insects. 4. The majority of water pollution incidents from farms are caused during storage and spreading of cattle and pig slurries. A higher proportion of organic cattle and virtually all organic pigs are kept on solid manure systems and therefore are les of a risk. 5. The nitrogen balance of individual 'conventional' and 'organic' systems will depend greatly on the circumstances and management practices of the individual farms. Consequently it is not possible to generalise that one system is always better than the other in terms of nitrate leaching risk. With this qualification the literature does indicate that generally, organic systems offer less risk of nitrate leaching. 6. Organic systems are less likely to cause loss of phosphate into surface and ground waters. Both leaching and loss in eroded soil are likely to be reduced. 7. Organic management practicess such as rotations, the regular use of manures and non-use of pesticides usually increase soil organic matter contents. 8. Organic practices are likely to increase earthworm numbers compared to conventional systems. The increased numbers are universally acknowledged to benefit soil fertility although such effects are difficult to quantify. 9. Soil erosion is less of a problem on organic units. 10. Accumulations of copper and zinc in soils are much reduced in organic systems because organic pig and poultry producers do not supplement feeds with these metals as growth promoters. Copper fungicides are more widely used on organic farms and their use should be carefully monitored to prevent harmful effects. 11. The practices adopted by organic farmers can reduce emissions of nitrous oxide and methane. Ammonia emissions will not necessarily be less in organic than in conventional farming. 12. Organic farmers adopt practices which benefit the landscape. They maintain and introduce features largely because they are required by the Organic Standards to do so. They introduce such management practices because they are technically necessary for successful organic production

Recent history, current status, conservation and management of native mammalian carnivore species in Great Britain

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record After historical declines in population sizes and ranges, we compare and contrast the recent history and contemporary variation in the status of Great Britain's eight native mammalian carnivore species from the 1960s to 2017. Wildcat Felis silvestris conservation status is unfavourable and is masked by hybridisation with domestic cats Felis catus. Red foxes Vulpes vulpes remain widespread but are currently declining. European otter Lutra lutra, European pine marten Martes martes and European polecat Mustela putorius populations are characterised by rapid recovery. Otters have almost completely recolonised Great Britain, polecats have expanded their range throughout southern Britain from refugia in Wales and pine martens have expanded their range from the Scottish Highlands. European badgers Meles meles have generally increased in population density. Status assessments of stoats Mustela erminea and weasels Mustela nivalis are data-deficient but available evidence suggests that stoats may have increased while weasels may have declined. Anthropogenic processes influencing carnivore status include legal protections, habitat quality, reintroductions, predator control, pollutants, hybridisation and diseases and their associated control practices. Population effects of contaminants, such as anticoagulant rodenticides, remain poorly characterised. The widespread interface with domestic and feral cats makes the wildcat's situation precarious. Recent declines in rabbit Oryctolagus cuniculus populations are a concern, given that several carnivore species depend on them as food. We conclude that, with the exception of the wildcat, the status of Great Britain's mammalian carnivores has markedly improved since the 1960s. Better understanding of the social aspects of interactions between humans and expanding predator populations is needed if conflict is to be avoided and long-term co-existence with people is to be possible.Vincent Wildlife TrustUniversity of Exete

Universal secure rank-metric coding schemes with optimal communication overheads

We study the problem of reducing the communication overhead from a noisy wire-tap channel or storage system where data is encoded as a matrix, when more columns (or their linear combinations) are available. We present its applications to reducing communication overheads in universal secure linear network coding and secure distributed storage with crisscross errors and erasures and in the presence of a wire-tapper. Our main contribution is a method to transform coding schemes based on linear rank-metric codes, with certain properties, to schemes with lower communication overheads. By applying this method to pairs of Gabidulin codes, we obtain coding schemes with optimal information rate with respect to their security and rank error correction capability, and with universally optimal communication overheads, when $n \leq m$, being $n$ and $m$ the number of columns and number of rows, respectively. Moreover, our method can be applied to other families of maximum rank distance codes when $n > m$. The downside of the method is generally expanding the packet length, but some practical instances come at no cost.Comment: 21 pages, LaTeX; parts of this paper have been accepted for presentation at the IEEE International Symposium on Information Theory, Aachen, Germany, June 201

The Quality and Outcomes of Care Provided to Patients with Cirrhosis by Advanced Practice Providers

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/1/hep30695.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/2/hep30695_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153696/3/hep30695-sup-0001-TableS1-S6.pd

Block-Simultaneous Direction Method of Multipliers: A proximal primal-dual splitting algorithm for nonconvex problems with multiple constraints

We introduce a generalization of the linearized Alternating Direction Method of Multipliers to optimize a real-valued function $f$ of multiple arguments with potentially multiple constraints $g_\circ$ on each of them. The function $f$ may be nonconvex as long as it is convex in every argument, while the constraints $g_\circ$ need to be convex but not smooth. If $f$ is smooth, the proposed Block-Simultaneous Direction Method of Multipliers (bSDMM) can be interpreted as a proximal analog to inexact coordinate descent methods under constraints. Unlike alternative approaches for joint solvers of multiple-constraint problems, we do not require linear operators $L$ of a constraint function $g(L\ \cdot)$ to be invertible or linked between each other. bSDMM is well-suited for a range of optimization problems, in particular for data analysis, where $f$ is the likelihood function of a model and $L$ could be a transformation matrix describing e.g. finite differences or basis transforms. We apply bSDMM to the Non-negative Matrix Factorization task of a hyperspectral unmixing problem and demonstrate convergence and effectiveness of multiple constraints on both matrix factors. The algorithms are implemented in python and released as an open-source package.Comment: 13 pages, 4 figure