15 research outputs found

    Pubertal mammary gland development: Insights from mouse models

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    During puberty the mammary gland develops from a rudimentary tree to a branched epithelial network of ducts which can support alveolar development and subsequent milk production during pregnancy and lactation. This process involves growth, proliferation, migration, branching, invasion, apoptosis and above all, tight regulation which allows these processes to take place simultaneously during the course of just a few weeks to create an adult gland. The process is under hormonal control and is thus coordinated with reproductive development. Mouse models, with overexpressed or knocked-out genes, have highlighted a number of pubertal mammary gland phenotypes and given significant insight into the regulatory mechanisms controlling this period of development. Here we review the published findings of the wide range of gene-manipulated mammary mouse models, documenting the common pubertal mammary gland phenotypes observed, and summarizing their contribution to our current understanding of how pubertal mammary gland development occurs

    Atherosclerosis

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    In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we elaborate on the disease process that can result in myocardial infarction (heart attack), ischaemic stroke and peripheral arterial disease. We have discussed broadly the homeostatic mechanisms in place that help autoregulate the cardiovascular system including the vital role of cholesterol and lipid clearance as well as the role lipid homeostasis plays in cardiovascular disease in the context of atherosclerosis. We then elaborate on the role played by the immune system in this setting, namely, major players from the innate and adaptive immune system, as well as discussing in greater detail specifically the role played by monocytes and macrophages.This chapter should represent an overview of the role played by the immune system in cardiovascular homeostasis; however further reading of the references cited can expand the reader's knowledge of the detail, and we point readers to many excellent reviews which summarise individual immune systems and their role in cardiovascular disease

    Remodeling of reactive lymph nodes: Dynamics of stromal cells and underlying chemokine signaling

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    International audienc

    Ammonoid Intraspecific Variability

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    Because ammonoids have never been observed swimming, there is no alternative to seeking indirect indications of the locomotory abilities of ammonoids. This approach is based on actualistic comparisons with the closest relatives of ammonoids, the Coleoidea and the Nautilida, and on the geometrical and physical properties of the shell. Anatomical comparison yields information on the locomotor muscular systems and organs as well as possible modes of propulsion while the shape and physics of ammonoid shells provide information on buoyancy, shell orientation, drag, added mass, cost of transportation and thus on limits of acceleration and swimming speed. On these grounds, we conclude that ammonoid swimming is comparable to that of Recent nautilids and sepiids in terms of speed and energy consumption, although some ammonoids might have been slower swimmers than nautilids
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