Sepsis – An Impendence That Needs a Global Solution Know Safety – No Infection

Sepsis has been called a hidden public health disaster. Sepsis arises from the host response to infection, which is directed to kill the invading pathogens. It is an extreme response to an infection and one of the most common causes of multiorgan failure. The human body sends a flood of chemicals into the bloodstream to fight the threat. This causes widespread inflammation which, over time, can slow blood flow and damage the organs. Sepsis is clinically diagnosed by a combination of clinical signs, laboratory tests and microbiologically confirmed by the detection of bacteria in blood by culture. Early and aggressive management with appropriate antimicrobials and rapid and complete hemodynamic stabilization has been shown to be associated with improved outcomes. Detecting sepsis early and starting immediate treatment is often the difference between life and death

An Enigma of Lower Airway Mucormycosis Infection

Saprophytic zygomycetes (e.g., Mucor, Rhizopus) are occasionally found in tissues of compromised hosts, in persons suffering from diabetes mellitus (particularly acidosis), extensive burns, leukemia, lymphoma or other chronic illness or immunosuppression. Rhizopus species, Mucor species and other zygomycetes invade the walls of blood vessels, producing thrombosis. This occurs commonly in paranasal sinus, the lungs and result in ischemic necrosis of surrounding tissue with an intense polymorphonuclear infiltrate. The organisms are rarely cultured during life but are seen in histologic preparations of tissues as broad nonseptate, irregular hyphae in thrombosed vessels or sinuses with surrounding leukocyte and giant cell response