637 research outputs found
Impact of physician specialty on classification of physician-perceived patient severity for patients with osteoarthritis
Lesbian and bisexual women's human rights, sexual rights and sexual citizenship: negotiating sexual health in England.
Lesbian and bisexual women's sexual health is neglected in much Government policy and practice in England and Wales. This paper examines lesbian and bisexual women's negotiation of sexual health, drawing on findings from a small research project. Themes explored include invisibility and lack of information, influences on decision-making and sexual activities and experiences of services and barriers to sexual healthcare. Key issues of importance in this respect are homophobic and heterosexist social contexts. Drawing on understandings of lesbian, gay and bisexual human rights, sexual rights and sexual citizenship, it is argued that these are useful lenses through which to examine and address lesbian and bisexual women's sexual health and related inequalities
Differential Cross Section for Higgs Boson Production Including All-Orders Soft Gluon Resummation
The transverse momentum distribution is computed for inclusive Higgs
boson production at the energy of the CERN Large Hadron Collider. We focus on
the dominant gluon-gluon subprocess in perturbative quantum chromodynamics and
incorporate contributions from the quark-gluon and quark-antiquark channels.
Using an impact-parameter -space formalism, we include all-orders
resummation of large logarithms associated with emission of soft gluons. Our
resummed results merge smoothly at large with the fixed-order
expectations in perturbative quantum chromodynamics, as they should, with no
need for a matching procedure. They show a high degree of stability with
respect to variation of parameters associated with the non-perturbative input
at low . We provide distributions for Higgs boson masses
from to 200 GeV. The average transverse momentum at zero rapidity
grows approximately linearly with mass of the Higgs boson over the range ~GeV. We provide analogous results
for boson production, for which we compute GeV. The
harder transverse momentum distribution for the Higgs boson arises because
there is more soft gluon radiation in Higgs boson production than in
production.Comment: 42 pages, latex, 26 figures. All figures replaced. Some changes in
wording. Published in Phys. Rev. D67, 034026 (2003
Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration
PURPOSE. Age-related macular degeneration (AMD) is the worldwide leading cause of blindness
among the elderly. Although genome-wide association studies (GWAS) have identified AMD
risk variants, their roles in disease etiology are not well-characterized, and they only explain a
portion of AMD heritability.
METHODS. We performed pathway analyses using summary statistics from the International
AMD Genomics Consortium’s 2016 GWAS and multiple pathway databases to identify
biological pathways wherein genetic association signals for AMD may be aggregating. We
determined which genes contributed most to significant pathway signals across the databases.
We characterized these genes by constructing protein-protein interaction networks and
performing motif analysis.
RESULTS. We determined that eight genes (C2, C3, LIPC, MICA, NOTCH4, PLCG2, PPARA, and
RAD51B) ‘‘drive’’ the statistical signals observed across pathways curated in the Kyoto
Encyclopedia of Genes and Genomes (KEGG), Reactome, and Gene Ontology (GO) databases.
We further refined our definition of statistical driver gene to identify PLCG2 as a candidate
gene for AMD due to its significant gene-level signals (P < 0.0001) across KEGG, Reactome,
GO, and NetPath pathways.
CONCLUSIONS. We performed pathway analyses on the largest available collection of advanced
AMD cases and controls in the world. Eight genes strongly contributed to significant pathways
from the three larger databases, and one gene (PLCG2) was central to significant pathways from
all four databases. This is, to our knowledge, the first study to identify PLCG2 as a candidate
gene for AMD based solely on genetic burden. Our findings reinforce the utility of integrating in
silico genetic and biological pathway data to investigate the genetic architecture of AMD
High-Density Amplicon Sequencing Identifies Community Spread and Ongoing Evolution of SARS-CoV-2 in the Southern United States
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constantly evolving. Prior studies focused on high-case-density locations, such as the northern and western metropolitan areas of the United States. This study demonstrates continued SARS-CoV-2 evolution in a suburban southern region of the United States by high-density amplicon sequencing of symptomatic cases. 57% of strains carry the spike D614G variant, which is associated with higher genome copy numbers, and its prevalence expands with time. Four strains carry a deletion in a predicted stem loop of the 3′ UTR. The data are consistent with community spread within local populations and the larger continental United States. The data instill confidence in current testing sensitivity and validate “testing by sequencing” as an option to uncover cases, particularly nonstandard coronavirus disease 2019 (COVID-19) clinical presentations. This study contributes to the understanding of COVID-19 through an extensive set of genomes from a non-urban setting and informs vaccine design by defining D614G as a dominant and emergent SARS-CoV-2 isolate in the United States
Effective interaction between helical bio-molecules
The effective interaction between two parallel strands of helical
bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using
computer simulations of the "primitive" model of electrolytes. In particular we
study a simple model for B-DNA incorporating explicitly its charge pattern as a
double-helix structure. The effective force and the effective torque exerted
onto the molecules depend on the central distance and on the relative
orientation. The contributions of nonlinear screening by monovalent counterions
to these forces and torques are analyzed and calculated for different salt
concentrations. As a result, we find that the sign of the force depends
sensitively on the relative orientation. For intermolecular distances smaller
than it can be both attractive and repulsive. Furthermore we report a
nonmonotonic behaviour of the effective force for increasing salt
concentration. Both features cannot be described within linear screening
theories. For large distances, on the other hand, the results agree with linear
screening theories provided the charge of the bio-molecules is suitably
renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS
The chi_b(nP) quarkonium states are produced in proton-proton collisions at
the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS
detector. Using a data sample corresponding to an integrated luminosity of 4.4
fb^-1, these states are reconstructed through their radiative decays to
Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks
corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new
structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is
also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes.
This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table,
corrected author list, matches final version in Physical Review Letter
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