You Built It, but Can You Talk About It?

Gettysburg College and Bucknell University have adopted library-led summer research fellowships for undergraduates that focus on teaching research skills with digital methods. In the summer of 2017, Gettysburg and Bucknell\u27s student cohorts met to learn how to create elevator speeches for their research topics; R.C. Miessler (Gettysburg), and Carrie Pirmann and Courtney Paddick (Bucknell), talk about the structure and goals of their summer programs, with a focus on their combined session and the importance of helping students learn how to talk about their research

Bridging Communities of Practice: Cross-Institutional Collaboration for Undergraduate Digital Scholars

At Bucknell University and Gettysburg College, an increasing focus on supporting creative undergraduate research as intensive, high-impact experiences has resulted in both institutions implementing library-led digital scholarship fellowships for their students. Gettysburg’s Digital Scholarship Summer Fellowship began in 2016, and Bucknell’s Digital Scholarship Summer Research Fellowship in 2017. While academic libraries have emerged as leaders on college campuses for digital humanities (DH) services, the programs at Gettysburg and Bucknell are distinctive in their structured curricula, a focus on independent student research, and the development of a local community of practice. In this chapter, we explore the development of cross-institutional communities of practice grounded in the digital humanities, and the ways in which we brought students in our two programs together

Bridging Communities of Practice: Cross-Institutional Collaboration for Undergraduate Digital Scholars

At Bucknell University and Gettysburg College, an increasing focus on supporting creative undergraduate research as intensive, high-impact experiences has resulted in both institutions implementing library-led digital scholarship fellowships for their students. Gettysburg’s Digital Scholarship Summer Fellowship began in 2016, and Bucknell’s Digital Scholarship Summer Research Fellowship in 2017.1 While academic libraries have emerged as leaders on college campuses for digital humanities (DH) services, the programs at Gettysburg and Bucknell are distinctive in their structured curricula, a focus on independent student research, and the development of a local community of practice. Each program situates undergraduate research in the field of digital humanities, providing methodological and technological support as students explore their own topics of humanistic inquiry and develop public-facing digital projects during the summer. [excerpt

Effects of Intermittent IL-2 Alone or with Peri-Cycle Antiretroviral Therapy in Early HIV Infection: The STALWART Study

The Study of Aldesleukin with and without antiretroviral therapy (STALWART) evaluated whether intermittent interleukin-2 (IL-2) alone or with antiretroviral therapy (ART) around IL-2 cycles increased CD4+ counts compared to no therapy

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD. © 2021, The Author(s).EU/EFPIA/Innovative Medicines Initiative 2 Joint Undertaking

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

Hot spots$ and mantle convection

SIGLEAvailable from British Library Document Supply Centre- DSC:D59182 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Experimental considerations for the calibration of personnel dosimeters with photons

The criteria for irradiating radiation dosimeters for test purposes are defined quite clearly in Draft ANSI Standard N13.11. In this Draft the use of phantoms, constructed of a near tissue equivalent material, is prescribed for backing the dosimeters while being irradiated, thus simulating a dosimeter being irradiated while attached to a person. When the phantom is placed in the photon beam it becomes a major source of scattered radiation. The scatter component into the dosimeter is a function of the energy of the photon beam and must be defined for each effective energy used. In addition, it is usually cost effective to irradiate more than one dosimeter at the same time, which may result in mutual interference from the dosimeters themselves. The effects of these parameters upon a centrally positioned dosimeter in the presence of a phantom are studied