Industrija čelika u novim članicama EU u usporedbi s globalnim trendovima

Accession of the metallurgically significant countries of the Central and Eastern Europe to the EU in 2004 was conditioned by fulfilling the Restructuring Programs as the foundation for achievement of competitiveness and guarancy of viability. The Restructuring Programs, which fulfilling and regular monitoring had lasted 5 years, demonstrated the right of the significant position of the steel industry in the new EU members, especially in Poland, Czech Republic, Slovakia, and in Hungary. The objective of the article is to point to the key elements in context of steel industry global trends, regarding either production or especially utility values and total consumption. In this connection, privatization took an important role too.Prinos metalurgije glavnih zemalja Srednje i Istočne Europe u EU u 2004. je bilo ostvarenje restrukturiranja programa kao temelj za postizanje konkurentnosti i jamstvo opstanka. Restrukturiranje programa, provedba i redovito praćenj za 5 godina opravdalo je značajno mjesto u industriji čelika u novim zemljama EU, naročito u Poljskoj, Češkoj, Slovačkoj i Mađarskoj. Ovaj članak ima za cilj istaknuti ključne elemente u razvojnom konextu industrija čelika u svijetu, kako u pogledu proizvodnje, a posebice u odnosu na kvalitete i ukupnu potrošnju. Važan element u tom pogledu, nastavak privatizacije

Insulin‐like growth factor 1 signaling in tenocytes is required for adult tendon growth

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154662/1/fsb2fj201901503r.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154662/2/fsb2fj201901503r-sup-0001.pd

Distinct Type of Transmission Barrier Revealed by Study of Multiple Prion Determinants of Rnq1

Prions are self-propagating protein conformations. Transmission of the prion state between non-identical proteins, e.g. between homologous proteins from different species, is frequently inefficient. Transmission barriers are attributed to sequence differences in prion proteins, but their underlying mechanisms are not clear. Here we use a yeast Rnq1/[PIN+]-based experimental system to explore the nature of transmission barriers. [PIN+], the prion form of Rnq1, is common in wild and laboratory yeast strains, where it facilitates the appearance of other prions. Rnq1's prion domain carries four discrete QN-rich regions. We start by showing that Rnq1 encompasses multiple prion determinants that can independently drive amyloid formation in vitro and transmit the [PIN+] prion state in vivo. Subsequent analysis of [PIN+] transmission between Rnq1 fragments with different sets of prion determinants established that (i) one common QN-rich region is required and usually sufficient for the transmission; (ii) despite identical sequences of the common QNs, such transmissions are impeded by barriers of different strength. Existence of transmission barriers in the absence of amino acid mismatches in transmitting regions indicates that in complex prion domains multiple prion determinants act cooperatively to attain the final prion conformation, and reveals transmission barriers determined by this cooperative fold

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis

BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide meta‐analysis of individual participant data from 20 634 hospitalised patients with laboratory‐confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. RESULTS: Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS o

Modelling and numerical simulation of RG-1 spring stroke hammer

Przedmiotem modelowania i symulacji jest oryginalny młot udarowy sprężynowy o nazwie RG -1, zaprojektowany i wykonany w Katedrze Mechaniki i Informatyki Stosowanej Wydziału Mechanicznego Wojskowej Akademii Technicznej w Warszawie [1]. Opracowano nieliniowy dyskretny model dynamiczny układu młot-badany element energochłonny-wibroizolacja-fundament-podłoże i wyznaczono wartości parametrów tego modelu. Sformułowano nieliniowe równania ruchu układu w niejawnej postaci i opracowano algorytm numerycznego całkowania tych równań. Opracowano program komputerowy KESHA v2 do symulacji numerycznej drgań układu. Przeprowadzono wstępne badania numeryczne energochłonności elementów kompozytowych cylindrycznych. W celu redukcji drgań wywołanych pracą młota, urządzenie posadowiono na żelbetowym fundamencie blokowym za pośrednictwem wibroizolacji GERB, którą stanowi układ czterech wibroizolatorów sprężynowych z tłumikami wiskotycznymi, typu KV-452-247 03. Badany młot udarowy należy do klasy młotów o średnich prędkościach uderzenia i średniej energii uderzenia (vu = 2,5-11 m/s; Eu = 0,1-6,0 kJ).The study presents modelling and numerical simulation of the RG -1 spring stroke hammer, using the multi-body dynamics approach. The device has been designed and erected at the Laboratory of Strength of Materials of the Department of Mechanics and Applied Computer Science of Military University of Technology, Poland. The study develops a nonlinear discrete dynamic model of the hammer-examined specimen-vibroisolation-foundation-subsoil system as well as determines the values of the system parameters. A nonlinear matrix equation of motion of the system has been formulated partly in the implicit form, taking into consideration subsequent/simultaneous stages of the dynamic process, i.e., rapid release of the ram catch, expansion of the mainsprings, impact of the ram onto the examined specimen, shock absorption by the elastomeric pads, reduction of the forced vibrations by GERB vibroisolators, propagation of the vibrations in the subsoil, free damped vibrations of the system. An implicit algorithm for numerical integration of equations of motion, based on Newmark's average acceleration method, has been formulated. The problem has been reflected by a computer programme written in Pascal. The study presents numerical simulations reflecting dynamic tests of energy-absorbing composite cylindrical specimens. The ram fixed to the moving traverse is able to induce progressive failure up to the specimen length minus 15 mm. A distance of 15 mm is reserved for gathering the material of the destroyed part of the specimen. If this distance is achieved, the moving traverse strikes onto the elastomeric pads fixed to the cantilevers. All possible breakings away are taken into consideration in the matrix equation of motion. In order to reduce vibrations, induced by rapid releasing of the ram catch and by the main impact, the device has been connected to RC block foundation with four viscoelastic KV-452-247 03 GERB vibroisolation units. The fundamental natural frequency of the system is close to f1 = 3.4 Hz. The exemplary time histories of vibrations of select subsystems, corresponding to the initial shortening of the mainsprings equal to s = 75 mm and 150 mm, number of bobs n = 0, and the carbon/epoxy specimen CE-1, are shown in Figs. 10 and 11. The multi-body dynamic model of the device, the dynamic equation of motion, the computer algorithms and the computer programme constitute an effective tool for predicting energy absorption of composite specimens and for assessment of vibration isolation effectiveness. The GERB vibroisolation has appeared to be very effective. The investigated device belongs to the hammers class of the medium impact velocities (vu = 2.5-11 m/s) and the medium impact energy (Eu = 0.1-6.0 kJ)

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G0 program initiation and ensures proper life span by controlling distal readouts, including the expression of specific genes. Here, we report that Rim15 coordinates transcription with posttranscriptional mRNA protection by phosphorylating the paralogous Igo1 and Igo2 proteins. This event, which stimulates Igo proteins to associate with the mRNA decapping activator Dhh1, shelters newly expressed mRNAs from degradation via the 5′-3′ mRNA decay pathway, thereby enabling their proper translation during initiation of the G0 program. These results delineate a likely conserved mechanism by which nutrient limitation leads to stabilization of specific mRNAs that are critical for cell differentiation and life span

Effect of electro-slag remelting on the quality of SW3S2 steel grade

22.00; Translated from Polish (Wiad. Hutn. 1985 (7-8) p. 205-208)SIGLEAvailable from British Library Document Supply Centre- DSC:9022.06(BISI--25503)T / BLDSC - British Library Document Supply CentreGBUnited Kingdo