A Model for Enveloping Space Station Logistics Requirements

Since the inception of the Space Station customer Logistics study, it became apparent that a modeling process was needed to provide insight into the many sensitivities and relationships which exist among the numerous variables which impact Space Station Customer Accommodations and Logistics Support Requirements with regard to their associated design requirements. such a model would provide the necessary and timely support to the Space Station designers and planners during the program\u27s early development. This paper will address the current design and operations of the Space Station in particular the Manufacturing and Technology Laboratory (MTL) which is the primary focus of the study and the model. Typical experiments planned for the MTL will be addressed as well as their on-orbit operational and logistical requirements. A detailed description of the model developed under the study along with some of its many applications for scoping Space Station Logistics Requirements will be presented

Technology Development Missions Concept Definition Study TDMX 2066 Large Inflatable/ Rigidized Structures

The advent of the Space Station will require the development and advancement of many new technologies. One of which is the development of Inflatable/ Rigidized Structures. This paper addresses the concept definition, feasibility and requirements for a Large Inflatable/Rigidized Hangar for Payload Servicing on the Space Station. Inflatable/Rigidized Structure Technology has existed for .many years, but applications of this technology to Space Based Elements has only begun during the past decade. Inflatable/Rigidized Structures offer a variety of benefits and applications to the Space Station, key of which is their low weight and volume requirements for transfer to the Station. A 60X40 foot foam hangar can be packaged and shipped in a specialized container approximately 46 m3 and will provide 3200 m3 of usable working/storage space. Previous studies have produced tremendous success in the area of design, fabrication and development of such Inflatable/Rigidized Structures as: a Spacelab transfer tunnel, module airlocks, platforms, large storage hangars, interconnect tunnels, and lunar habitation modules. This paper will address the technology issues/advancements which must be meet, the requirements for accommodations on the Space Station, such as crew and equipment requirements to assemble the hangar at the Station. Pre-launch ground requirements will also be addresses, which include new advanced packaging techniques for Rigidized structures. Typical Ground and On-orbit scenarios will be provided. Finally a preliminary evolutionary plan will be presented which indicates the major experiment development phases from ground based prototypes to full scale Stat-ion deployment

The Relation Between Ocular Dominance, Handidness, and Visual Acuity

It is of certain theoretical and academic interest to learn whether persons who are right handed also tend to be right-eyed or visa versa. The question often comes up as to whether one who has marked ocular dominance tends to use the better eye or whether the eye being used most gets weaker or stronger. Data were available that could be analyzed to throw light on these problems which might be formulated into the following questions: 1. Is there a tendency for right-handed persons to be right-eyed and left-handed persons to be left-eyed? 2. Is the dominant eye the strongest eye

Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development

Histone deacetylases (HDACs) catalyze the removal of acetyl molecules from histone and nonhistone substrates playing important roles in chromatin remodeling and control of gene expression. Class I HDAC1 is a critical regulator of cell cycle progression, cellular proliferation and differentiation during development; it is also regulated by many post-translational modifications (PTMs). Herein we characterize a new mitosis-specific phosphorylation of HDAC1 driven by Aurora kinases A and B. We show that this phosphorylation affects HDAC1 enzymatic activity and it is critical for the maintenance of a proper proliferative and developmental plan in a complex organism. Notably, we find that Aurora-dependent phosphorylation of HDAC1 regulates histone acetylation by modulating the expression of genes directly involved in the developing zebrafish central nervous system. Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology

Joint Endeavor Toward Sustainable Mountain Development: Research at the Institute for Interdisciplinary Mountain Research of the Austrian Academy of Sciences

The sustainable development of mountain regions requires inter-and transdisciplinary knowledge. The Institute for Interdisciplinary Mountain Research contributes to this global endeavor as part of the Austrian Academy of Sciences and as a member of international scientific networks, together with local partners and stakeholders. As a joint effort of individual researchers covering multiple fields, this article highlights our views on mountains as research objects, the phenomena we investigate as parts of entire mountain systems, and the synergies and differences of the disciplinary frames within which we work

FLT3 mutations in canine acute lymphocytic leukemia

<p>Abstract</p> <p>Background</p> <p>FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, and a poorer prognosis. A better understanding of the molecular consequences of FLT3 activation would allow improved therapeutic strategies in these patients. Canine lymphoproliferative diseases, including lymphoma and acute leukemias, share evolutionarily conserved chromosomal aberrations and exhibit conserved mutations within key oncogenes when compared to their human counterparts. A small percentage of canine acute lymphocytic leukemias (ALL) also exhibit <it>FLT3 </it>ITD mutations.</p> <p>Methods</p> <p>We molecularly characterized <it>FLT3 </it>mutations in two dogs and one cell line, by DNA sequencing, gene expression analysis via quantitative real-time PCR, and sensitivity to the FLT3 inhibitor lestaurtinib via <it>in vitro </it>proliferation assays. FLT 3 and downstream mediators of FLT3 activation were assessed by Western blotting.</p> <p>Results</p> <p>The canine B-cell leukemia cell line, GL-1, and neoplastic cells from 2/7 dogs diagnosed cytologically with ALL were found to have <it>FLT3 </it>ITD mutations and <it>FLT3 </it>mRNA up-regulation. Lestaurtinib, a small molecule FLT3 inhibitor, significantly inhibited the growth of GL-1 cells, while not affecting the growth of two other canine lymphoid cell lines without the <it>FLT3 </it>mutation. Finally, western blots were used to confirm the conserved downstream mediators of <it>FLT3 </it>activating mutations.</p> <p>Conclusions</p> <p>These results show that ALL and FLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias.</p

Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

Gene networks are an efficient route for associating candidate genes with biological processes. Here, networks are used to discover more than 15 new genes for ribosomal subunit maturation, rRNA processing, and ribosomal export from the nucleus