1,020 research outputs found
A Study of a Mini-drift GEM Tracking Detector
A GEM tracking detector with an extended drift region has been studied as
part of an effort to develop new tracking detectors for future experiments at
RHIC and for the Electron Ion Collider that is being planned for BNL or JLAB.
The detector consists of a triple GEM stack with a small drift region that was
operated in a mini TPC type configuration. Both the position and arrival time
of the charge deposited in the drift region were measured on the readout plane
which allowed the reconstruction of a short vector for the track traversing the
chamber. The resulting position and angle information from the vector could
then be used to improve the position resolution of the detector for larger
angle tracks, which deteriorates rapidly with increasing angle for conventional
GEM tracking detectors using only charge centroid information. Two types of
readout planes were studied. One was a COMPASS style readout plane with 400
micron pitch XY strips and the other consisted of 2x10mm2 chevron pads. The
detector was studied in test beams at Fermilab and CERN, along with additional
measurements in the lab, in order to determine its position and angular
resolution for incident track angles up to 45 degrees. Several algorithms were
studied for reconstructing the vector using the position and timing information
in order to optimize the position and angular resolution of the detector for
the different readout planes. Applications for large angle tracking detectors
at RHIC and EIC are also discussed.Comment: Submitted to the IEEE Transactions on Nuclear Scienc
Thermal Injury Causes DNA Damage and Lethality in Unheated Surrounding Cells: Active Thermal Bystander Effect
Direct heat exposure to cells causes protein degradation and DNA damage, which can lead to genetic alteration and cell death, but little is known about heat-induced effects on the surrounding tissue. After burns or laser surgery, loss of viability in the surrounding tissue has been explained by a temperature gradient due to heat diffusion. This study shows that, in the absence of any direct heating, heat diffusion, or cell-to-cell contact, “bystander” cells that share the medium with heat-exposed cells exhibit DNA damage, apoptosis, and loss of viability. We coin this phenomenon “active thermal bystander effect” (ATBE). Significant ATBE was induced by fibroblasts exposed for 10minutes to a temperature range of 44–50°C (all P<0.011). The ATBE was not induced by cells heated to lethality above 54°C and immediate medium exchange did not suppress the effect. Therefore, the thermal bystander effect appears to be an active process in which viable, heat-injured cells induce a signal cascade and/or mediator that damages or kills surrounding bystander cells. The ATBE may have clinical relevance for acute burn trauma, hyperthermic treatments, and distant tissue damage after localized heat stress
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Fractional Skin Harvesting: Autologous Skin Grafting without Donor-site Morbidity
Background: Conventional autologous skin grafts are associated with significant donor-site morbidity. This study was conducted to determine feasibility, safety, and efficacy of a new strategy for skin grafting based on harvesting small columns of full-thickness skin with minimal donor-site morbidity. Methods: The swine model was used for this study. Hundreds of full-thickness columns of skin tissue (~700 µm diameter) were harvested using a custom-made harvesting device, and then applied directly to excisional skin wounds. Healing in donor and graft sites was evaluated over 3 months by digital photographic measurement of wound size and blinded, computer-aided evaluation of histological features and compared with control wounds that healed by secondary intention or with conventional split-thickness skin grafts (STSG). Results: After harvesting hundreds of skin columns, the donor sites healed rapidly without scarring. These sites reepithelialized within days and were grossly and histologically indistinguishable from normal skin within 7 weeks. By contrast, STSG donor sites required 2 weeks for reepithelialization and retained scar-like characteristics in epidermal and dermal architecture throughout the experiment. Wounds grafted with skin columns resulted in accelerated reepithelialization compared with ungrafted wounds while avoiding the “fish-net” patterning caused by STSG. Conclusion: Full-thickness columns of skin can be harvested in large quantities with negligible long-term donor-site morbidity, and these columns can be applied directly to skin wounds to enhance wound healing
Azimuthal Correlations in the Target Fragmentation Region of High Energy Nuclear Collisions
Results on the target mass dependence of proton and pion pseudorapidity
distributions and of their azimuthal correlations in the target rapidity range
are presented. The data have been taken with the
Plastic-Ball detector set-up for 4.9 GeV p + Au collisions at the Berkeley
BEVALAC and for 200 GeV/ p-, O-, and S-induced reactions on
different nuclei at the CERN-SPS. The yield of protons at backward rapidities
is found to be proportional to the target mass. Although protons show a typical
``back-to-back'' correlations, a ``side-by-side'' correlation is observed for
positive pions, which increases both with target mass and with impact parameter
of a collision. The data can consistently be described by assuming strong
rescattering phenomena including pion absorption effects in the entire excited
target nucleus.Comment: 7 pages, figures included, complete postscript available at
ftp://qgp.uni-muenster.de/pub/paper/azi-correlations.ps submitted to Phys.
Lett.
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
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