A comparison of methods for calculating general practice level socioeconomic deprivation

Background: A measure of the socioeconomic deprivation experienced by the registered patient population of a general practice is of interest because it can be used to explore the association between deprivation and a wide range of other variables measured at practice level. If patient level geographical data are available a population weighted mean area-based deprivation score can be calculated for each practice. In the absence of these data, an area-based deprivation score linked to the practice postcode can be used as an estimate of the socioeconomic deprivation of the practice population. This study explores the correlation between Index of Multiple Deprivation 2004 (IMD) scores linked to general practice postcodes (main surgery address alone and main surgery plus any branch surgeries), practice population weighted mean IMD scores, and practice level mortality (aged 1 to 75 years, all causes) for 38 practices in Rotherham UK. Results: Population weighted deprivation scores correlated with practice postcode based scores (main surgery only, Pearson r = 0.74, 95% CI 0.54 to 0.85; main plus branch surgeries, r = 0.79, 95% CI 0.63 to 0.89). All cause mortality aged 1 to 75 correlated with deprivation (main surgery postcode based measure, r = 0.50, 95% CI 0.22 to 0.71; main plus branch surgery based score, r = 0.55, 95% CI 0.28 to 0.74); population weighted measure, r = 0.66, 95% CI 0.43 to 0.81). Conclusion: Practice postcode linked IMD scores provide a valid proxy for a population weighted measure in the absence of patient level data. However, by using them, the strength of association between mortality and deprivation may be underestimated

Synthesising and utilising complex evidence to inform policy in education and health.

Oslo, Norway, May 19 to 21, 200

Measuring micro-organism gas production

Transducer, which senses pressure buildup, is easy to assemble and use, and rate of gas produced can be measured automatically and accurately. Method can be used in research, in clinical laboratories, and for environmental pollution studies because of its ability to detect and quantify rapidly the number of gas-producing microorganisms in water, beverages, and clinical samples

Droplet size and morphology characterization for diesel sprays under atmospheric operating conditions

The shape of microscopic fuel droplets may differ from the perfect sphere, affecting their external surface area and thus the heat transfer with the surrounding gas. Hence there is a need for the characterization of droplet shapes, and the estimation of external surface area, in order to enable the development of physically accurate mathematical models for the heating and evaporation of diesel fuel sprays. We present ongoing work to automat-ically identify and reconstruct the morphology of fuel droplets, primarily focusing in this study on irregularly-shaped, partially-deformed and oscillating droplets under atmospheric conditions. We used direct imaging tech-niques based on long-working distance microscopy and ultra-high-speed video to conduct a detailed temporal investigation of droplet morphology. We applied purpose-built algorithms to extract droplet size, velocity, vol-ume and external surface area from the microscopic ultra-high-speed video frames. High resolution images of oscillating droplets and a formation of a droplet form ligament, sphericity factors, volume as well as external surface area are presented for 500 bar injection pressure in the near nozzle region (up to 0.7 mm from nozzle exit) under atmospheric conditions. We observed a range of different liquid structures, including perfectly spher-ical, non-spherical droplets and stretched ligaments. We found that large droplets and ligaments exceeding the size of the nozzle hole could be found at the end of injection. In order to estimate droplet volume and external surface area from two-dimensional droplet information, a discrete revolution of the droplet silhouette about its major centroidal axis was used. Special attention was paid to the estimation of actual errors in the prediction of volume and surface characteristics from a droplet silhouette. In addition to the estimation of droplet volume and external surface area, the actual shape reconstruction in 3D coordinates from a droplet silhouette was performed in order to enable future numerical modelling studies of real droplets

Fast iterative solution of reaction-diffusion control problems arising from chemical processes

PDE-constrained optimization problems, and the development of preconditioned iterative methods for the efficient solution of the arising matrix system, is a field of numerical analysis that has recently been attracting much attention. In this paper, we analyze and develop preconditioners for matrix systems that arise from the optimal control of reaction-diffusion equations, which themselves result from chemical processes. Important aspects in our solvers are saddle point theory, mass matrix representation and effective Schur complement approximation, as well as the outer (Newton) iteration to take account of the nonlinearity of the underlying PDEs

The Cluster Distribution as a Test of Dark Matter Models. IV: Topology and Geometry

We study the geometry and topology of the large-scale structure traced by galaxy clusters in numerical simulations of a box of side 320 $h^{-1}$ Mpc, and compare them with available data on real clusters. The simulations we use are generated by the Zel'dovich approximation, using the same methods as we have used in the first three papers in this series. We consider the following models to see if there are measurable differences in the topology and geometry of the superclustering they produce: (i) the standard CDM model (SCDM); (ii) a CDM model with $\Omega_0=0.2$ (OCDM); (iii) a CDM model with a `tilted' power spectrum having $n=0.7$ (TCDM); (iv) a CDM model with a very low Hubble constant, $h=0.3$ (LOWH); (v) a model with mixed CDM and HDM (CHDM); (vi) a flat low-density CDM model with $\Omega_0=0.2$ and a non-zero cosmological $\Lambda$ term ($\Lambda$CDM). We analyse these models using a variety of statistical tests based on the analysis of: (i) the Euler-Poincar\'{e} characteristic; (ii) percolation properties; (iii) the Minimal Spanning Tree construction. Taking all these tests together we find that the best fitting model is $\Lambda$CDM and, indeed, the others do not appear to be consistent with the data. Our results demonstrate that despite their biased and extremely sparse sampling of the cosmological density field, it is possible to use clusters to probe subtle statistical diagnostics of models which go far beyond the low-order correlation functions usually applied to study superclustering.Comment: 17 pages, 7 postscript figures, uses mn.sty, MNRAS in pres

A Comparison of Risk Exposure in Aquaculture and Agricultural Businesses

Agriculture and aquaculture have common features associated with their biological nature affecting risk exposure of the businesses. The aim of this paper is to compare risk exposure in salmon farming and agricultural enterprises in Norway by using an implicit error component model to examine the risk structure of yields, prices and economic returns at the farm level. Results indicate a higher farm-level year-to-year variability in yields, prices and economic returns in salmon farming than in agricultural enterprises. The variability in livestock enterprises was generally lower than for crop enterprises. Return on assets was highest in salmon farming with an average annual return of 9.2%. All of the agricultural farm types exhibited a negative average return on assets on average. Stochastic dominance tests of the distribution of economic returns from aquaculture and agricultural farm types showed salmon farming to be the most risk efficient alternative and salmon farming was most attractive from an investor’s perspective.Risk analysis, variability, Norway, Risk and Uncertainty,

Diphtheria prophylaxis with alum precipitated toxoid

(1) Active immunisation is the best prophylactic measure we possess against diphtheria as the isolation of cases and carriers has proved a failure in preventing the spread of the disease. (2) The success of the various prophylactics depends on the basal immunity of the child population (especially A.P.T.). (3) T.A.F. is widely used in both children and adults. F.T. and A.P.T. should be confined to children. (4) It is unwise to employ 'one shot immunisation' with A.P.T. except in closed communities of high basal immunity. (5) The 'detector' dose method of using A.P.T. seems likely to give as good results as T.A.F. and perhaps may be an even better prophylactic in combating 'gravis' diphtheria. (6) The best time to immunise is as soon as possible after a child's first birthday. (7) Reactions are not likely to occur if the child is immunised before going to school. (8) The pre-school child should receive almost as much attention as the school child. (9) The general public should be educated to receive diphtheria immunisation as a natural event in a child's life. (10) When an epidemic occurs it is too late to immunise

Border parasites: schistosomiasis control among Uganda's fisherfolk

Copyright @ 2012 Taylor & Francis. This article has been made publically available through the Brunel Open Access Publishing Fund.It is recognized that the control of schistosomisais in Uganda requires a focus on fisherfolk. Large numbers suffer from this water-borne parasitic disease; notably along the shores of lakes Albert and Victoria and along the River Nile. Since 2004, a policy has been adopted of providing drugs, free of charge, to all those at risk. The strategy has been reported to be successful, but closer investigation reveals serious problems. This paper draws upon long-term research undertaken at three locations in northwestern and southeastern Uganda. It highlights consequences of not engaging with the day to day realities of fisherfolk livelihoods; attributable, in part, to the fact that so many fisherfolk live and work in places located at the country’s international borders, and to a related tendency to treat them as "feckless" and "ungovernable". Endeavours to roll out treatment end up being haphazard, erratic and location-specific. In some places, concerted efforts have been made to treat fisherfolk; but there is no effective monitoring, and it is difficult to gauge what proportion have actually swallowed the tablets. In other places, fisherfolk are, in practice, largely ignored, or are actively harassed in ways that make treatment almost impossible. At all sites, the current reliance upon resident "community" drug distributors or staff based at static clinics and schools was found to be flawed.The Schistosomiasis Control Initiative, Imperial College, under the auspices of the Bill and Melinda Gates Foundation