421 research outputs found
Modulation of fenretinide induced cell death in neuroblastoma
Neuroblastoma is a childhood tumor that, despite intensive therapy, has a poor prognosis especially in high risk patients. Therefore, new therapeutic options are needed to improve the outcome of these patients. The research described in this thesis attempts to unravel the apoptosis-inducing mechanism of fenretinide in neuroblastoma and, in order to increase its anti-tumor effects, we investigated possibilities for combination therapy
Gravity gradiometer system for Earth Exploration
We develop a gravity gradiometer (GG) for use on planetary missions to planets like Mars and Jupiter. With some modifications this development is extended to include (airborne) applications for the Dutch exploratory industry. We adapt key technology of the space based GG for the use in an environment with considerable acceleration noise. The major benefit is the considerable decrease in weight and size with the presently used gradiometer systems
Ecological compensation of highway impacts; negotiated trade-off or no-net-loss?
The ecological compensation principle was introduced in the Dutch
Structural Scheme for the Rural Areas (1993). The principle aims to
enhance the input of natural conservation interests in decision-making
on large development projects and to counterbalance the adverse impacts
of such projects when implemented. The thesis describes the process of
implementing the ecological compensation principle within the
Directorate-General of Public Works and Water Management
(Rijkswaterstaat) as initiator of highway projects. Additionally, it has
developed a theoretical and practical framework for ecological
compensation. Ecological compensation and related issues have been
investigated in the different stages of planning, decision-making and
realisation of highway projects. The thesis' leading element is the
incentive-based character of compensating for impacts according to the
Structural Scheme. This implies the parties involved are obliged to
reach agreement on finding and realising compensation sites. Besides
some specific conditions, there is still no legislation that facilitates
the initiatiors' acquisition of lands for compensation purposes.1. The Institute of Environmental Sciences of Leiden University (Centrum voor Milieuwetenschappen Leiden 2. The Dutch Ministry of Transport, Public Works and Water Management (Rijkswaterstaat), Road and Hydraulic Engineering Division (Dienst Weg- en Waterbouwkunde), Delft.Environmental Biology - ol
Nonlinearities and Effects of Transverse Beam Size in Beam Position Monitors (revised)
The fields produced by a long beam with a given transverse charge
distribution in a homogeneous vacuum chamber are studied. Signals induced by a
displaced finite-size beam on electrodes of a beam position monitor (BPM) are
calculated and compared to those produced by a pencil beam. The non-linearities
and corrections to BPM signals due to a finite transverse beam size are
calculated for an arbitrary chamber cross section. Simple analytical
expressions are given for a few particular transverse distributions of the beam
current in a circular or rectangular chamber. Of particular interest is a
general proof that in an arbitrary homogeneous chamber the beam-size
corrections vanish for any axisymmetric beam current distribution.Comment: REVTeX, 8 pages, 9 figures. Corrected Eqs. (7),(22),(25) and Figs.
2-9. Expande
Natuurcompensatie A50 (Eindhoven-Oss) : een oriƫnterend onderzoek
VakpublicatieInstitute of Environmental Science
Milieu-effect studie bouwlokaties Leidse regio : de effecten van nieuwe woningbouwlokaties en bedrijfsterreinen in de Leidse regio op natuur en milieu
VakpublicatieInstitute of Environmental Science
Met oevers meer natuur : op zoek naar referentiebeelden en maatregelen voor aanleg, inrichting en beheer van natuurvriendelijke oevers
VakpublicatieInstitute of Environmental Science
Supported polysilsesquioxane membrane and production thereof
Membranes of the invention comprise a hybrid silica film on a organic polymer support. The silica comprises organic bridging groups bound to two or more silicon atoms, in particular at least 1 of said organic bridging groups per 10 silicon atoms. The membranes can be produced by dry chemistry processes, in particular plasma-enhanced vapour deposition of bridged silane precursors, or by wet chemistry involving hydrolysis of the bridged silane precursors. The membranes are inexpensive and efficient for separation of small molecules and filtration processes
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