Drug–drug interactions in vestibular diseases, clinical problems, and medico-legal implications

Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug–drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies

Haemorrhage from varicose veins and varicose ulceration: A systematic review

Varicose veins (VVs) and varicose ulceration (VU) are usually considered non-life-threatening conditions, but in some cases they can lead to major complications such as fatal bleeding. The aim of this systematic review is to evidence the most updated information on bleeding from VV and VU. As evidence acquisition, we planned to include all the studies dealing with “Haemorrhage/Bleeding” and “VVs/VU”. We excluded all the studies, which did not properly fit our research question, and with insufficient data. As evidence synthesis, of the 172 records found, after removing of duplicates, and after records excluded in title and abstract, 85 matched our inclusion criteria. After reading the full-text articles, we decided to exclude 68 articles because of the following reasons: (1) not responding properly to our research questions; (2) insufficient data; the final set included 17 articles. From literature searching, we identify the following main issues to be discussed in the review: epidemiology and predisposing factors, pathophysiology and forensic aspects, first aid. It has been estimated that deaths for bleeding due to peripheral venous problems account up to 0.01% of autopsy cases. From a pathological point of view, venous bleeding may arise from either acute or chronic perforation of an enlarged vein segment through the weakened skin. From a forensic point of view, in cases of fatal haemorrhage the death scene can even simulate non-natural events, due to crime or suicide. In most cases, incorrect first aid led to fatal complications. Further investigation on epidemiology and prevention measures are needed

Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection – Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practice

37nononenoneFineschi V.; Aprile A.; Aquila I.; Arcangeli M.; Asmundo A.; Bacci M.; Cingolani M.; Cipolloni L.; D'Errico S.; de Casamassimi I.; Mizio G.D.; Paolo M.D.; Focardi M.; Frati P.; Gabbrielli M.; Russa R.L.; Maiese A.; Manetti F.; Martelloni M.; Mazzeo E.; Montana A.; Neri M.; Padovano M.; Pinchi V.; Pomara C.; Ricci P.; Salerno M.; Santurro A.; Scopetti M.; Testi R.; Turillazzi E.; Vacchiano G.; Crivelli F.; Bonoldi E.; Facchetti F.; Nebuloni M.; Sapino A.Fineschi, V.; Aprile, A.; Aquila, I.; Arcangeli, M.; Asmundo, A.; Bacci, M.; Cingolani, M.; Cipolloni, L.; D'Errico, S.; de Casamassimi, I.; Mizio, G. D.; Paolo, M. D.; Focardi, M.; Frati, P.; Gabbrielli, M.; Russa, R. L.; Maiese, A.; Manetti, F.; Martelloni, M.; Mazzeo, E.; Montana, A.; Neri, M.; Padovano, M.; Pinchi, V.; Pomara, C.; Ricci, P.; Salerno, M.; Santurro, A.; Scopetti, M.; Testi, R.; Turillazzi, E.; Vacchiano, G.; Crivelli, F.; Bonoldi, E.; Facchetti, F.; Nebuloni, M.; Sapino, A

White Paper on Industrial Applications of Computer Vision and Pattern Recognition

The paper provides a summary of the contributions to the industrial session at ICIAP2013, describing a few practical applications of Video Analysis, in the Surveillance and Security field. The session has been organized to stimulate an open discussion within the scientific community of CVPR on new emerging research areas which deserve particular attention, and may contribute to the improvement of industrial applications in the near future