Comments on Marine Litter in Oceans, Seas and Beaches: Characteristics and Impacts.

Marine litter is observed along shorelines, pelagic, benthic marine and lake systems all around the globe. On beaches, litter creates aesthetic and related economic problems because a clean beach is one of the most important characteristics of a seaside resort required by visitors. Litter can reach the marine environment from marine or land activities but it is estimated that 80% originates from land-based sources. The marine-based sources of litter include all types of sea-going vessel and offshore installations, the most abundant plastic debris in the oceans being derelict (lost or improperly discarded) fishing gear. Most of marine litter is composed by plastics due to their greater durability and persistence, combined with plastic rising production and low rates of recovery. Special importance is linked to microplastics because their ubiquity, persistence, mechanical effects on biota and the ecosystem because of ingestion by organisms and their toxic potential. As plastics degrade they can release toxic chemicals initially incorporated during their manufacturing or persistent organic pollutants and heavy metals sorbed to their surfaces in the environment. Such toxins can disrupt endocrine functions and cause harmful reproductive and developmental effects in aquatic animals

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population