Non-equilibrium transport through a disordered molecular nanowire

We investigate the non-equilibrium transport properties of a disordered molecular nanowire. The nanowire is regarded as a quasi-one-dimensional organic crystal composed of self-assembled molecules. One orbital and a single random energy are assigned to each molecule while the intermolecular coupling does not fluctuate. Consequently, electronic states are expected to be spatially localized. We consider the regime of strong localization, namely, the localization length is smaller than the length of the molecular wire. Electron-vibron interaction, taking place in each single molecule, is also taken into account. We investigate the interplay between disorder and electron-vibron interaction in response to either an applied electric bias or a temperature gradient. To this end, we calculate the electric and heat currents when the nanowire is connected to leads, using the Keldysh non-equilibrium Green's function formalism. At intermediate temperature, scattering by disorder dominates both charge and heat transport. We find that the electron-vibron interaction enhances the effect of the disorder on the transport properties due to the exponential suppression of tunneling

Global tectonic studies: Hotspots and anomalous topography

Volcanic activity on Earth and its secular variations are compared with that on other terrestrial planets. Activity at divergent, transform, and convergent plate margins is described with particular emphasis on hot spots and flood basalts. The timing and causing of uplifting above 500 meters, which in not associated with either plate boundaries or the normal nonplate margin edges of continents is considered with particular focus on the Guyana Highlands in southern Venezuela and western British Guiana, and the Brazilian Highlands in the central, eastern, and southern parts of the country. The mode and mechanism of plateau uplifting and the re-elevation of old mountain belts and subsidence of intra-continental basins are also discussed

GENETIC VARIABILITY AMONG CATTLE BREEDS FOR BEEF PRODUCTION

Between-breed variation in body weight, food intake, carcass composition, milk yield, efficiency of food conversion during growth and maintenance efficiency in adult cattle was examined in a multibreed experiment at the AFRC Animal Breeding Research Organisation. Females from 11 beef , 8 dual-purpose and 6 dairy breeds were fed a complete pelleted diet (AA6) ad libitum from weaning at 12 weeks of age until the birth of their third calf. Females were mated by AI to produce both purebred and crossbred progeny which were reared under the same conditions and slaughtered at either 24, 48 or 72 weeks of age. In addition, non-pregnant, non-lactating mature females from two beef breeds, two dairy breeds and one dual purpose breed were fed for prolonged periods on fixed levels of the same AA6 diet until an equilibrium body weight had been attained. There was significant variation among breeds for body weight, cumulated intake and cumulated food efficiency over the age range of 12 to 72 weeks. At 12 weeks of age the between-breed variation as a proportion of the total (t) was 0.71 for body weight, 0.62 for cumulated intake and 0.15 for cumulated food efficiency. Breed and sex had Significant effects on carcass composition at all three age of 24, 48 and 72 weeks. Heterosis in carcass composition although significant at 24 weeks declined at subsequent ages. Beef breeds when compared with dairy breeds had on average daily lactation yields that were half as high, total lactation yields that were 1/3 as high and lactation lengths that were 2/3 as long. Maintenance efficiency in mature cattle varied with potential milk yield, beef breeds being about 20% more efficient than dairy breeds

GENETIC VARIABILITY AMONG CATTLE BREEDS FOR BEEF PRODUCTION

Between-breed variation in body weight, food intake, carcass composition, milk yield, efficiency of food conversion during growth and maintenance efficiency in adult cattle was examined in a multibreed experiment at the AFRC Animal Breeding Research Organisation. Females from 11 beef , 8 dual-purpose and 6 dairy breeds were fed a complete pelleted diet (AA6) ad libitum from weaning at 12 weeks of age until the birth of their third calf. Females were mated by AI to produce both purebred and crossbred progeny which were reared under the same conditions and slaughtered at either 24, 48 or 72 weeks of age. In addition, non-pregnant, non-lactating mature females from two beef breeds, two dairy breeds and one dual purpose breed were fed for prolonged periods on fixed levels of the same AA6 diet until an equilibrium body weight had been attained. There was significant variation among breeds for body weight, cumulated intake and cumulated food efficiency over the age range of 12 to 72 weeks. At 12 weeks of age the between-breed variation as a proportion of the total (t) was 0.71 for body weight, 0.62 for cumulated intake and 0.15 for cumulated food efficiency. Breed and sex had Significant effects on carcass composition at all three age of 24, 48 and 72 weeks. Heterosis in carcass composition although significant at 24 weeks declined at subsequent ages. Beef breeds when compared with dairy breeds had on average daily lactation yields that were half as high, total lactation yields that were 1/3 as high and lactation lengths that were 2/3 as long. Maintenance efficiency in mature cattle varied with potential milk yield, beef breeds being about 20% more efficient than dairy breeds

Assessment of a novel 32-channel phased array for cardiovascular hybrid PET/MRI imaging: MRI performance.

BACKGROUND: Cardiovascular imaging using hybrid positron emission tomography (PET) and magnetic resonance imaging (MRI) requires a radio frequency phased array resonator capable of high acceleration factors in order to achieve the shortest breath-holds while maintaining optimal MRI signal-to-noise ratio (SNR) and minimum PET photon attenuation. To our knowledge, the only two arrays used today for hybrid PET/MRI cardiovascular imaging are either incapable of achieving high acceleration or affect the PET photon count greatly. PURPOSE: This study is focused on the evaluation of the MRI performance of a novel third-party prototype 32-channel phased array designed for simultaneous PET/MRI cardiovascular imaging. The study compares the quality parameters of MRI parallel imaging, such as g-factor, noise correlation coefficients, and SNR, to the conventional arrays (mMR 12-channel and MRI-only 32-channel) currently used with hybrid PET/MRI systems. The quality parameters of parallel imaging were estimated for multiple acceleration factors on a phantom and three healthy volunteers. Using a Germanium-68 (Ge-68) phantom, preliminary measurements of PET photon attenuation caused by the novel array were briefly compared to the photon counts produced from no-array measurements. RESULTS: The global mean of the g-factor and SNR CONCLUSIONS: The MRI performance of the novel PET/MRI 32-channel array qualifies it to be a viable alternative to the conventional arrays for cardiovascular hybrid PET/MRI. A detailed evaluation of the novel array\u27s PET performance remains to be conducted, but cursory assessment promises significantly reduced attenuation

Refining multiple sequence alignments with conserved core regions

Accurate multiple sequence alignments of proteins are very important to several areas of computational biology and provide an understanding of phylogenetic history of domain families, their identification and classification. This article presents a new algorithm, REFINER, that refines a multiple sequence alignment by iterative realignment of its individual sequences with the predetermined conserved core (block) model of a protein family. Realignment of each sequence can correct misalignments between a given sequence and the rest of the profile and at the same time preserves the family's overall block model. Large-scale benchmarking studies showed a noticeable improvement of alignment after refinement. This can be inferred from the increased alignment score and enhanced sensitivity for database searching using the sequence profiles derived from refined alignments compared with the original alignments. A standalone version of the program is available by ftp distribution () and will be incorporated into the next release of the Cn3D structure/alignment viewer

Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia

Dementia has been shown to be associated with agonistic autoantibodies. The deleterious action of autoantibodies on the {alpha}1-adrenergic receptor for brain vasculature has been demonstrated in animal studies. In the current study, 169 patients with dementia were screened for the presence of agonistic autoantibodies. 47% of patients suffering from mild to moderate Alzheimer's disease and/or vascular dementia carried these autoantibodies. Eight patients positive for autoantibodies underwent immunoadsorption. Patients treated on four consecutive days were subsequently negative for autoantibodies and displayed stabilization of cognitive and mental condition during 12-18 months' follow-up. In patients treated for 2-3 days, autoantibodies were reduced by only 78%. They suffered a rebound of autoantibodies during follow-up, benefited from immunoadsorption too, but their mental parameters worsened. We provide first data on the clinical relevance of agonistic autoantibodies in dementia and show that immunoadsorption is safe and efficient in removing autoantibodies with overall benefits for patients

MRI T2 and T1ρ relaxation in patients at risk for knee osteoarthritis: A systematic review and meta-analysis

© 2019 The Author(s). Background: Magnetic resonance imaging (MRI) T2 and T1ρ relaxation are increasingly being proposed as imaging biomarkers potentially capable of detecting biochemical changes in articular cartilage before structural changes are evident. We aimed to: 1) summarize MRI methods of published studies investigating T2 and T1ρ relaxation time in participants at risk for but without radiographic knee OA; and 2) compare T2 and T1ρ relaxation between participants at-risk for knee OA and healthy controls. Methods: We conducted a systematic review of studies reporting T2 and T1ρ relaxation data that included both participants at risk for knee OA and healthy controls. Participant characteristics, MRI methodology, and T1ρ and T2 relaxation data were extracted. Standardized mean differences (SMDs) were calculated within each study. Pooled effect sizes were then calculated for six commonly segmented knee compartments. Results: 55 articles met eligibility criteria. There was considerable variability between scanners, coils, software, scanning protocols, pulse sequences, and post-processing. Moderate risk of bias due to lack of blinding was common. Pooled effect sizes indicated participants at risk for knee OA had lengthened T2 relaxation time in all compartments (SMDs from 0.33 to 0.74; p \u3c 0.01) and lengthened T1ρ relaxation time in the femoral compartments (SMD from 0.35 to 0.40; p \u3c 0.001). Conclusions: T2 and T1ρ relaxation distinguish participants at risk for knee OA from healthy controls. Greater standardization of MRI methods is both warranted and required for progress towards biomarker validation