95 research outputs found
Editorial: Mitochondrial dysfunction and cardiovascular diseases
- Publication venue
- place:AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
- Publication date
- 01/01/2021
- Field of study
A deeper understanding of the molecular mechanisms underlying the development and progression of cardiovascular diseases represents a major goal in cardiovascular medicine. Mitochondrial dysfunction has emerged as major player in the development of cardiovascular diseases, with potential therapeutic implications. Mitochondrial dysfunction encompasses mitochondrial complex disruption, mitochondrial uncoupling, and cristae remodeling and swelling, which in turn cause ROS accumulation, energy stress, and cell death
Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein.
- Author
- Publication venue
- 'Rockefeller University Press'
- Publication date
- Field of study
Physician shadowing by college students: what do patients think?
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction
- Author
- A Widmer
- Adam Sukiennik
- Aldona Kubica
- AM Arruda-Olson
- BM Scirica
- D Rott
- EJ Velazquez
- Eliano Pio Navarese
- F Schiele
- Grazyna Odrowaz-Sypniewska
- Iwona Swiatkiewicz
- Jacek Kubica
- JE MĂžller
- JG Cleland
- JJ Smit
- Joanna Gierach
- JS Zebrack
- K Uehara
- M Griselli
- M Kruk
- M Nian
- M Suleiman
- Marek Kozinski
- MB Pepys
- NB Schiller
- ND Brunetti
- NG Frangogiannis
- P Aggelopoulos
- P Ohlmann
- Przemyslaw Magielski
- R Kitsis
- RA Weir
- RB Devereux
- RF Bonvini
- RM Lang
- S Verma
- S Verma
- S Ărn
- SK James
- T Anzai
- T Anzai
- T KĂŒmler
- T Takahashi
- TD Barrett
- Tomasz Fabiszak
- WK Lagrand
- Publication venue
- SP BirkhÀuser Verlag Basel
- Publication date
- 01/01/2012
- Field of study
Objective To assess the usefulness of in-hospital measurement
of C-reactive protein (CRP) concentration in
comparison to well-established risk factors as a marker of
post-infarct left ventricular systolic dysfunction (LVSD) at
discharge.
Materials and methods Two hundred and four consecutive
patients with ST-segment-elevation myocardial
infarction (STEMI) were prospectively enrolled into the
study. CRP plasma concentrations were measured before
reperfusion, 24 h after admission and at discharge with an
ultra-sensitive latex immunoassay.
Results CRP concentration increased significantly during
the first 24 h of hospitalization (2.4 ± 1.9 vs. 15.7 ± 17.0
mg/L; p\0.001) and persisted elevated at discharge
(14.7 ± 14.7 mg/L), mainly in 57 patients with LVSD
(2.4 ± 1.8 vs. 25.0 ± 23.4 mg/L; p\0.001; CRP at discharge
21.9 ± 18.6 mg/L). The prevalence of LVSD was
significantly increased across increasing tertiles of CRP
concentration both at 24 h after admission (13.2 vs. 19.1
vs. 51.5 %; p\0.0001) and at discharge (14.7 vs. 23.5 vs.
45.6 %; p\0.0001). Multivariate analysis demonstrated
CRP concentration at discharge to be an independent
marker of early LVSD (odds ratio of 1.38 for a 10 mg/L
increase, 95 % confidence interval 1.01â1.87; p\0.04).
Conclusion Measurement of CRP plasma concentration
at discharge may be useful as a marker of early LVSD in
patients after a first STEMI
ICF components of corresponding outcome measures in flexor tendon rehabilitation â a systematic review
- Author
- A Cetin
- A Cieza
- AS Drummond
- BW Su
- C Bircan
- C Jerosch-Herold
- Christian GrĂŒneberg
- CK Kitsis
- D Elliot
- D Elliot
- Daniel Scheible
- DT Gault
- EJ May
- F Langlais
- FH Peck
- Gerhard Mehrtens
- GL Clark
- Gudrun Neises
- H Hatanaka
- J Braga-Silva
- JC MacDermid
- JM Hunter
- K Ozturk
- KL Silfverskiold
- L Adolfsson
- L Klein
- LC Olivier
- LK Hung
- M Riaz
- MJ Saldana
- P Clavert
- P Smith
- R Friedel
- RB Evans
- Renée Oltman
- RH Gelberman
- SB Harris
- SC Chai
- T Ipsen
- TA Stamm
- TA Stamm
- VM Tottenham
- W Baer
- WA Steiner
- World Health Organization
- YC So
- Publication venue
- BioMed Central
- Publication date
- 01/10/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>The International Classification of Functioning, Disability and Health (ICF) delivers a holistic approach to health conditions. The objective of the present study is to provide an overview of flexor tendon rehabilitation outcome measures with respect to ICF components. Furthermore, it aims to investigate to which extent current assessments measure aspects of health according to these components primarily focussing on <it>activity </it>and <it>participation</it>.</p> <p>Methods</p> <p>A systematic literature review was conducted to identify all studies meeting the inclusion criteria. Studies were only included if they assessed more than <it>body function and body structure </it>and referred to the ICF components <it>activity </it>and <it>participation</it>. The outcome measures were analysed and their linkage to the ICF components were investigated to examine to which degree aspects of health outcome as defined by the ICF were considered.</p> <p>Results</p> <p>As anticipated, the application of outcome measures after flexor tendon repair is non conform. In many studies the emphasis still lies on physical impairment neglecting activity limitations and participation restrictions.</p> <p>Aspects of health after flexor tendon repair could be assessed more adequately and cover patients' needs more sufficiently by choosing outcome measures which refer to all aspects of functioning.</p> <p>Conclusion</p> <p>The ICF can help to identify aspects of health which are not being considered. The ICF can help promote further development of adequate outcome measures including activity limitation and participation restrictions by targeting patient centred goals and respecting patients' needs.</p
Priorities in Cardio-Oncology Basic and Translational Science
- Author
- Ameri Pietro
- Ardehali Hossein
- Asnani Aarti
- Burridge Paul
- Cabrera JosĂ© Ăngel
- Costa Ambra
- CĂłrdoba RaĂșl
- de Boer Rudolf A.
- de Castro Javier
- Dent Susan
- Engelbertsen Daniel
- FernĂĄndez-Velasco MarĂa
- Fradley Mike
- Fuster José J.
- Fuster Valentin
- GalĂĄn-Arriola Carlos
- GarcĂa-Lunar InĂ©s
- Ghigo Alessandra
- GonzĂĄlez-Neira Anna
- Hirsch Emilio
- Ibåñez Borja
- Kitsis Rickard N.
- Konety Suma
- Ky Bonnie
- Lyon Alexander R.
- LĂłpez-FernĂĄndez Teresa
- Martin Pilar
- Mauro Adolfo G.
- Mazo Vega Manuel M.
- Meijers Wouter C.
- Neilan Tomas G.
- Rassaf Tienush
- Ricke-Hoch Melanie
- Salloum Fadi N.
- Sepulveda Pilar
- Thavendiranathan Paaladinesh
- Tocchetti Carlo G.
- van der Meer Peter
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Despite improvements in cancer survival, cancer therapyârelated cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to improve patient outcomes, and the bidirectional challenges of translating basic research to clinical care. We acknowledge that there are many additional therapies that are of significance but were not topics of discussion at this symposium. We hope that through this symposium-based review we can highlight the knowledge gaps and clinical priorities to inform the design of future studies that aim to prevent and mitigate cardiovascular disease in cancer patients and survivors.</p
Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit
- Author
- Abbott S
- Abdulaal Y
- Abercrombie J
- Acheson A
- Afshar S
- Ah-Chuen J
- Ahmed T
- Akhtar M
- Akram F
- Alderson D
- Aldred E
- Ali A
- Aly M
- Amajuoyi A
- Amin V
- Anderson D
- Anderson I
- Anderson O
- Andreou A
- Ansari A
- Appleton S
- Ardley R
- Arshad F
- Ashour O
- Asour A
- Athem A
- Athersmith M
- Ayoub F
- Azeem H
- Azhar B
- Bach S
- Badenoch T
- Baillie C
- Bandyopadhyay D
- Barker J
- Barker S
- Barkham B
- Baron R
- Barrie J
- Barry-Yarrow E
- Bashir G
- Battersby N
- Bazoua G
- Behar N
- Bellam S
- Berger C
- Bhandari S
- Bhasin S
- Biggs S
- Bisset C
- Blake L
- Blencowe N
- Boam T
- Boddy A
- Boereboom C
- Bogdan M
- Bogle R
- Bohra P
- Boland M
- Bolkan H
- Borg C
- Boulton R
- Bouras G
- Boxel G
- Boyer M
- Boyle J
- Branagan G
- Brewer H
- Briggs C
- Broadhurst J
- Brown E
- Brown J
- Brown L
- Brown O
- Burns K
- Butcher K
- Butler M
- Byrne B
- Campbell L
- Capper C
- Cartmell M
- Cash T
- Chan S
- Chandratreya N
- Chapman J
- Chapman S
- Charalabopoulos A
- Cheek C
- Chok S
- Choong W
- Chow M
- Chowdhury J
- Coe P
- Conaghan P
- Conn G
- Cook N
- Cook T
- Cooper S
- Cornish J
- Cotton D
- Cox C
- Coyne P
- Crook R
- Crozier J
- Cuffolo G
- Cunha P
- Curtis N
- Cutting J
- Da Costa K
- Das B
- Davenport M
- Davies J
- Davies M
- Davies MM
- Davies T
- Day A
- Dayal S
- Dean S
- Demetriou G
- Dengu F
- Dennis R
- Dent H
- Dent P
- Deputy M
- Devoto L
- Di Benedetto G
- Dindyal S
- Donnelly E
- Doody P
- Douka E
- Downham C
- Dowson H
- Drake TM
- Edent H
- Edgerton K
- Ekpete N
- El Farran M
- El-Sharif M
- Elamin O
- Eljaafari M
- Elsaid N
- Evans J
- Evans M
- Ewe R
- Ewing A
- Exarchou K
- Fallaize R
- Faoury M
- Farag S
- Farinella E
- Faulkner G
- Fearnhead NS
- Ferguson H
- Fisher O
- Fletcher J
- Forouzanfar A
- Foster A
- Fox R
- Francis N
- Fretwell V
- Fung D
- Gammeri E
- Garnham J
- Geraghty A
- Gilbert A
- Gill C
- Gill M
- Gillespie M
- Giordano P
- Glasbey J
- Goh M
- Golder A
- Green N
- Gregoir T
- Grey T
- Groundwater E
- Grove T
- Growcott S
- Gunasekaran S
- Habib H
- Haddow J
- Halahakoon V
- Halkias C
- Hall C
- Hamady Z
- Hampson A
- Hancock L
- Hanna T
- Hannay J
- Hare S
- Harikrishnan A
- Harries R
- Harris G
- Hartley J
- Harvey K
- Hawkin P
- Hawkins J
- Healy R
- Heard R
- Heartshorne R
- Heller S
- Hendra L
- Herrod P
- Heywood N
- Hicks G
- Hind D
- Hobson B
- Hollyman M
- Holtham S
- Holtham S
- Hope C
- Hopley P
- Hossain T
- Hossaini S
- Howse F
- Hubbard T
- Humphreys A
- Ikram H
- Ioannis M
- Iqbal M
- Iqbal N
- Jain R
- Jatania J
- Jenkinson P
- Jokhan S
- Jones A
- Jones C
- Jones L
- Joshi H
- Joshi K
- Joy M
- Jull P
- Kakaniaris G
- Kakaniaris G
- Kallam R
- Kane E
- Kang P
- Kanitkar R
- Kauser S
- Kazmi F
- Kedrzycki M
- Kelly S
- Kendall J
- Khan M
- Khan T
- King G
- Kisiel A
- Kitsis C
- Kolawole I
- Korambayil S
- Kosasih S
- Kosti A
- Kotb A
- Kouris S
- Kshatriya K
- Kumar S
- Lafaurie G
- Lal R
- Lau A
- Lazim T
- Lazim T
- Lazzaro A
- Lee E
- Lee K
- Lee MJ
- Lefroy R
- Leinhardt D
- Leinhardt D
- Lennon H
- Leong K
- Levy B
- Lewis C
- Lim E
- Lim J
- Lindley S
- Liu D
- Lloyd P
- Locker D
- Lockwood S
- Lowe C
- Lund J
- Lunevicius R
- Lunt A
- Lutfi S
- Luther A
- Luwemba S
- Mahankali-Rao P
- Mahroof S
- Mai D
- Majid S
- Malik A
- Malik K
- Mann K
- Mansour S
- Manu N
- Mapara R
- Marriott P
- Martin C
- Martin J
- Martin R
- Mason C
- Massey L
- Mathias J
- Mathur P
- Maude K
- Maynard N
- McArthur D
- McCain S
- McCluney S
- McFall M
- McIlroy B
- McKay S
- McKinley N
- McNair A
- McWhirter D
- Mekhail P
- Mellor K
- Merchant J
- Merker L
- Messenger D
- Miles A
- Mir S
- Mishra A
- Mistry P
- Miu V
- Moat M
- Mockford K
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- Mohamed I
- Mondragon-Pritchard M
- Moore N
- Moretti L
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- Morrison-Jones V
- Moss J
- Moug S
- Mountford D
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- Mulholland J
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- Murgitroyd E
- Murray D
- Murugaiyan K
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- Northover J
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- Panchasara B
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- Perin G
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- Pranesh N
- Proctor V
- Pywell S
- Qureshi A
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- Rahman M
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- Rangarajan K
- Rashid M
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- Robinson D
- Rossi B
- Rutherford F
- Sadien I
- Saghir T
- Sahnan K
- Salahia G
- Sarveswaran J
- Saunders M
- Sayers AE
- Scott B
- Scott K
- Seager A
- Seal S
- Sezen E
- Shaban F
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- Shah P
- Shahmohammadi M
- Shamsiddinova A
- Shankar S
- Sharpe A
- Shatkar V
- Sheel A
- Shields T
- Shinkwin M
- Shurmer J
- Siddika A
- Siddiqui S
- Silva L
- Simson R
- Sinclair P
- Singh B
- Singh S
- Sivaraj J
- Skaife P
- Skelly B
- Skinner A
- Slim N
- Smart C
- Smart N
- Smith F
- Smith I
- Smith R
- Spence G
- Sreedhar A
- Steinke J
- Stevenson L
- Stewart-Parker E
- Stott M
- Stubbs B
- Stubbs B
- Stylianides N
- Subramonia S
- Swinkin M
- Swinscoe M
- Symons N
- Tahir W
- Taj T
- Takacs K
- Tam J
- Tan K
- Tani S
- Tanner N
- Tao D
- Taylor M
- Thava B
- Thippeswamy K
- Thomas C
- Thompson E
- Thompson R
- Thompson-Reil C
- Thorn C
- Tierney G
- Tongo F
- Toth G
- Turnbull A
- Turnbull J
- Valero C
- Varcada M
- Venn M
- Ventham N
- Venza M
- Verjee A
- Vimalachandran D
- Virlos I
- Wade T
- Wafi A
- Waite K
- Walker M
- Walker N
- Walker T
- Walsh CJ
- Walsh U
- Wardle S
- Warner R
- Watfah J
- Watson N
- Watt J
- Watts J
- Wayman J
- Weegenaar C
- West H
- West M
- Whitehurst L
- Whyler M
- Wiggans M
- Wijeyekoon S
- Wild J
- Williams G
- Williams R
- Williamson A
- Williamson J
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- Winter A
- Wolpert L
- Wong J
- Yeap E
- Yeong T
- Zaman S
- Zappa B
- Zosimas D
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/10/2020
- Field of study
Background:
Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. The aim of this study was to describe current management and outcomes of patients with obstructed hernia in the UK as identified in the National Audit of Small Bowel Obstruction (NASBO).
Methods:
NASBO collated data on adults treated for SBO at 131 UK hospitals between January and March 2017. Those with obstruction due to abdominal wall hernia were included in this study. Demographics, co-morbidity, imaging, operative treatment, and in-hospital outcomes were recorded. Modelling for factors associated with mortality and complications was undertaken using Cox proportional hazards and multivariable regression modelling.
Results:
NASBO included 2341 patients, of whom 415 (17·7 per cent) had SBO due to hernia. Surgery was performed in 312 (75·2 per cent) of the 415 patients; small bowel resection was required in 198 (63·5 per cent) of these operations. Non-operative management was reported in 35 (54 per cent) of 65 patients with a parastomal hernia and in 34 (32·1 per cent) of 106 patients with an incisional hernia. The in-hospital mortality rate was 9·4 per cent (39 of 415), and was highest in patients with a groin hernia (11·1 per cent, 17 of 153). Complications were common, including lower respiratory tract infection in 16·3 per cent of patients with a groin hernia. Increased age was associated with an increased risk of death (hazard ratio 1·05, 95 per cent c.i. 1·01 to 1·10; P = 0·009) and complications (odds ratio 1·05, 95 per cent c.i. 1·02 to 1·09; P = 0·001).
Conclusion:
NASBO has highlighted poor outcomes for patients with SBO due to hernia, highlighting the need for quality improvement initiatives in this group
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
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- Aflaki E.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- AntĂłn Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- AraĂșjo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
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- Baldari CT
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- Basagoudanavar SH
- Bassham DC
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- Batoko H
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- Buitrago-Molina LE
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- BurĂłn MI
- Bustos V
- Butturini E
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- Zhivotovsky B
- Zhong Q
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- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
- Author
- A Aouacheria
- A Aouacheria
- A Aranovich
- A Ashkenazi
- A Ashkenazi
- A Ashkenazi
- A Bernet
- A Buque
- A Chiche
- A Conte
- A Costanzo
- A Crockford
- A Degterev
- A Degterev
- A Dey
- A Gast
- A Gross
- A Hakkim
- A Hamacher-Brady
- A Hunger
- A Kaczmarek
- A Kamb
- A Koenig
- A Kotschy
- A Letai
- A Linkermann
- A Linkermann
- A Linkermann
- A Linkermann
- A Mousa
- A Muir
- A Mukherjee
- A Nilsson
- A Oberst
- A Oberst
- A Pagotto
- A Pyakurel
- A Rongvaux
- A Rubartelli
- A Sahaboglu
- A Seiler
- A Serrano-Puebla
- A Shamas-Din
- A Sistigu
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Sumoza-Toledo
- A Sundararaman
- A Tittarelli
- A Trautmann
- A Villunger
- A Witt
- A Zychlinsky
- AA Fatokun
- AA Mailleux
- Aaron Ciechanover
- AB Pardee
- Abhishek D. Garg
- AC Bellail
- AC Schinzel
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- Adi Kimchi
- AE Alsop
- AE Feldstein
- AJ Schile
- AL Anding
- AL Genevois
- Alexey V. Antonov
- AM Chinnaiyan
- AM Distefano
- AM Dudek
- AM Verhagen
- AN Antony
- AN Barclay
- Ana J. GarcĂa-SĂĄez
- Andreas Linkermann
- Andreas Strasser
- Andreas Villunger
- Andrew Oberst
- Andrew Thorburn
- Antonella Sistigu
- AP West
- AR Delbridge
- AT Schneider
- AT Ting
- AT Ting
- Atan Gross
- AV Follis
- AV Jacobsen
- AV Vaseva
- AV Vaseva
- AW Roberts
- B Antonsson
- B Aslan
- B Conradt
- B Fadeel
- B Gerlach
- B Gibert
- B Gooptu
- B McDonald
- B Schellenberg
- B Van Do
- B Xia
- BA Carlson
- BA Hilton
- BA Napier
- BB Aggarwal
- BC Barnhart
- Bertrand Joseph
- Beth Levine
- BG Childs
- BG Childs
- BG Childs
- BG Lambrus
- BG Yipp
- Boris Turk
- Boris Zhivotovsky
- BP Eckelman
- BP Eckelman
- BR Stockwell
- Brent R. Stockwell
- Brian D. Dynlacht
- BT Cookson
- C Bergmann
- C Dominguez-Brauer
- C Du
- C Frezza
- C Gerle
- C Guenebeaud
- C Gunther
- C Gunther
- C Helmke
- C Hernandez
- C Hockings
- C Lood
- C Lopez-Garcia
- C Lopez-Otin
- C Lopez-Otin
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- C Louandre
- C Nelson
- C Oberle
- C Piot
- C Rogers
- C Scaffidi
- C Vanpouille-Box
- C White
- C Xie
- Carlos LĂłpez-OtĂn
- Carmen Garrido
- Catherine Brenner
- CC Wu
- CD Simpson
- CD Wiley
- Cecilia M.P. Rodrigues
- CF Wenceslau
- Christoph Borner
- CJ Kearney
- CK Ea
- CK Lam
- CK McPhee
- CL Buchheit
- CL Buchheit
- CL Buchheit
- CL Case
- Claudio Hetz
- CM Henry
- CN Casson
- Colin S. Duckett
- CP Baines
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- CP Dillon
- CP Dillon
- CP Dillon
- Cristina Muñoz-Pinedo
- CT Tan
- D Brenner
- D Brough
- D Chen
- D Crighton
- D Denton
- D Denton
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- D Gatica
- D Goldschneider
- D Kranz
- D Li
- D Malin
- D Martin-Sanchez
- D Merino
- D Munoz-Espin
- D Piani
- D Ren
- D Stojkov
- D Tang
- D Tang
- D Vercammen
- D Vercammen
- D Wallach
- D Weaver
- D Yang
- DA Flusberg
- DA Rodriguez
- Daniel J. Klionsky
- Daolin Tang
- David C. Rubinsztein
- David M. Pereira
- David W. Andrews
- David Wallach
- DC Gray
- DH Cho
- Didac Carmona-Gutierrez
- Dieter Adam
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- Domagoj Vucic
- Douglas R. Green
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- E Arama
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- E Lachaier
- E Lafont
- E Meunier
- E Perez
- E Vacchelli
- E Varfolomeev
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- E Zandi
- E Zandi
- EA Miao
- Edward A. Miao
- EF Lee
- EH Cheng
- EH Cheng
- EH Hinchcliffe
- EJ Park
- Eleonora Candi
- Eli Arama
- Emad S. Alnemri
- Emily H. Cheng
- Emre Sayan
- Enrico Lugli
- Eric H. Baehrecke
- Erwin F. Wagner
- Evripidis Gavathiotis
- EY Bassoy
- Eyal Gottlieb
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- Francesca Bernassola
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- Francesco Di Virgilio
- Francis K.-M. Chan
- Frank Madeo
- G Brumatti
- G Casinelli
- G Denecker
- G Dewson
- G Droga-Mazovec
- G Ichim
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- G Kroemer
- G Kroemer
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- Gabriel A. Rabinovich
- Gabriel Nuñez
- Gerald M. Cohen
- Gerry Melino
- Gian Maria Fimia
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- Guido Kroemer
- GW Dorn 2nd
- Gwenola Manic
- Gyorgy Hajnoczky
- Gyorgy Szabadkai
- H Appelqvist
- H Dai
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- H Du
- H Hsu
- H Imai
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- H Kazama
- H Kim
- H Kim
- H Li
- H Li
- H Otera
- H Parker
- H Puthalakath
- H Puthalakath
- H Sakahira
- H Wajant
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Yang
- H Yang
- H Yuan
- H Yuan
- H Yuan
- H Zhang
- H Zhang
- HA Park
- Hamsa Puthalakath
- Hans-Uwe Simon
- HC Chen
- HE Kamber Kaya
- Henning Walczak
- Herbert W. Virgin
- Hidenori Ichijo
- Hinrich Gronemeyer
- HL Tang
- I Adkins
- I Amelio
- I Jaco
- I Jorgensen
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- I Maejima
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- Ilio Vitale
- IP Nezis
- IP Nezis
- IR Powley
- Isaac S. Harris
- Ivano Amelio
- J Alanko
- J Bove
- J Brojatsch
- J Campisi
- J Cedervall
- J Chai
- J Chai
- J Chang
- J Desai
- J Desai
- J Ding
- J Ding
- J Fitamant
- J Fombonne
- J Fucikova
- J Fullgrabe
- J Fullgrabe
- J Geng
- J Gilloteaux
- J He
- J He
- J Hitomi
- J Huai
- J Huun
- J Karch
- J Kaur
- J Kers
- J Kim
- J Li
- J Lin
- J Liu
- J Maelfait
- J Majkut
- J Michels
- J Nunnari
- J Nylandsted
- J Parrish
- J Pecot
- J Puccini
- J Seo
- J Shi
- J Shi
- J Shi
- J Silke
- J Sosna
- J Suzuki
- J Suzuki
- J Suzuki
- J Warne
- J Wu
- J Xu
- J Yang
- J Yu
- J Zhang
- J Zhao
- J Zou
- J. Marie Hardwick
- JA DiDonato
- JA Ewald
- JA Hagar
- JA Mason
- JA Rickard
- James A. Wells
- Jan Paul Medema
- JC Acosta
- JC Hamann
- JD Bernet
- JE Chipuk
- JE Chipuk
- JE Kokoszka
- JE Vince
- JE Vince
- Jean-Christophe Marine
- Jean-Claude Martinou
- Jeffery D. Molkentin
- Jerry E. Chipuk
- JH Woo
- JI Jun
- JJ Guan
- JJ Schulman
- JL Lin
- JM Bravo-San Pedro
- JM Brouwer
- JM Deursen van
- JM Gump
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- Jochen H.M. Prehn
- John A. Cidlowski
- John J. Lemasters
- John M. Abrams
- John Silke
- John W. Elrod
- Josef M. Penninger
- JP Coppe
- JP Friedmann Angeli
- JPF Angeli
- JQ Kwong
- JQ Kwong
- JT Sockolosky
- JU Schweichel
- Juan R. Cubillos-Ruiz
- Junying Yuan
- JV Brower
- JV Lu
- JW Harper
- JW Upton
- JW Upton
- K Csomos
- K Eichholz
- K Huang
- K Kawane
- K Li
- K Martinod
- K Mills
- K Moriwaki
- K Moriwaki
- K Newton
- K Newton
- K Newton
- K Ruckdeschel
- K Schleich
- K Schleich
- K Segawa
- K Segawa
- K Sharma
- K Shimada
- K Tada
- K Tracy
- K Vlantis
- K Wang
- K Yacobi-Sharon
- K Zhang
- Karen H. Vousden
- Katiuscia Bianchi
- KD Metzler
- KD Metzler
- KE Gascoigne
- KE Lawlor
- Kevin M. Ryan
- KF Hsu
- KG Fleten
- KH Jang
- KH Szymczyk
- KJ Mackenzie
- KJ Neelsen
- KJ Oh
- KJ Weigel
- KK David
- KK David
- KL Lu
- KL OâNeill
- Klas Blomgren
- Klaus-Michael Debatin
- KM Backus
- KN Alavian
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- KS Lang
- L Antonioli
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- L Dara
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- L Dorstyn
- L Duprez
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- L Franchi
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- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
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- L Galluzzi
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- L Galluzzi
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- L Groth-Pedersen
- L Jiang
- L Jiang
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- L Lin
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- L Mosteiro
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- S Aits
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- S Shanmughapriya
- S Shimizu
- S Shimizu
- S Solier
- S Sun
- S Suzuki
- S Tan
- S Torii
- S Wang
- S Wen
- S Xu
- S Yoon
- S Yoon
- S Yousefi
- S Yousefi
- S Zamorano
- S Zelenay
- S Zhu
- SA Andrabi
- SA Andrabi
- SA Andrabi
- SA Conos
- SA Lipton
- SA Oakes
- Sam W. Lee
- SB Berger
- SB Ma
- SB Willingham
- Scott J. Dixon
- Scott W. Lowe
- SE Kim
- SE Kim
- Seamus J. Martin
- SH Baek
- Sharad Kumar
- Shazib Pervaiz
- Shigekazu Nagata
- Simone Fulda
- SJ Clarke
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Gardai
- SJ Martin
- SJ Riedl
- SJ Wang
- SJ Yu
- SK Dasari
- SL Petersen
- SL Thompson
- SL Wong
- SM Frisch
- SM Harding
- SM Kallenberger
- SM Kavuri
- SM Man
- SM Man
- SM Man
- Sonia Melino
- SR Clark
- SR Woo
- Stephen W.G. Tait
- Stuart A. Aaronson
- Stuart A. Lipton
- SW Tait
- SW Tait
- SW Tait
- SW Yu
- SW Yu
- T Bergsbaken
- T Eggert
- T Eisenberg
- T Kamijo
- T Kirkegaard
- T Kirkegaard
- T Konig
- T Kuriakose
- T Kurz
- T Kurz
- T Kurz
- T Kuwana
- T Li
- T Lindsten
- T Mizuta
- T Moldoveanu
- T Moldoveanu
- T Motte Rouge de La
- T Nakagawa
- T Panaretakis
- T Panaretakis
- T Piyush
- T Raveh
- T Saleh
- T Shibue
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Varanita
- T Vervliet
- T Xu
- T Xu
- T Zhang
- TA Fuchs
- TB Kang
- TC Cheng
- Ted M. Dawson
- Theocharis Panaretakis
- Thomas Kaufmann
- Thomas Rudel
- TJ Daish
- TJ Sargeant
- TK Chang
- TL Haas
- TM Fu
- TM Ng
- Tom Luedde
- Tom Vanden Berghe
- TP Garner
- TS Luongo
- TS Luongo
- TT Cung
- TT Renault
- TV Denisenko
- TV Lee
- TW Kang
- U Fischer
- Ute M. Moll
- V Brinkmann
- V Brinkmann
- V Giorgio
- V Giorgio
- V Giorgio
- V Hornung
- V Izzo
- V Kondylis
- V Labi
- V Papayannopoulos
- V Purvanov
- V Sica
- V Turk
- V Turk
- VA Rathinam
- Valina L. Dawson
- VE Kagan
- VI Maltez
- Vincenzo De Laurenzi
- Vincenzo DâAngiolella
- Vishva M. Dixit
- VL Dawson
- VS Marsden
- VS Viswanathan
- W Chen
- W He
- W Hou
- W Lu
- W Zhou
- Wafik S. El-Deiry
- Walter Malorni
- WC Yeh
- WD Cook
- Will Wood
- William J. Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WP Roos
- WS Hambright
- WS Yang
- WS Yang
- WS Yang
- WS Yang
- WT He
- X Chen
- X Chen
- X Hu
- X Jiang
- X Li
- X Liu
- X Liu
- X Luo
- X Qu
- X Song
- X Sun
- X Sun
- X Sun
- X Sun
- X Wang
- X Wang
- X Zhang
- XM Yin
- XM Yin
- XM Zhao
- XN Wu
- Y Aachoui
- Y Aachoui
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Fernandez-Marrero
- Y Fuchs
- Y Fuchs
- Y Ishizaki
- Y Ito
- Y Lee
- Y Li
- Y Li
- Y Liu
- Y Liu
- Y Luo
- Y Ma
- Y Ma
- Y Morizane
- Y Ou
- Y Pang
- Y Rong
- Y Shlyakhtina
- Y Subburaj
- Y Suzuki
- Y Tsujimoto
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Xie
- Y Xie
- Y Xie
- Y Zaltsman
- Y Zermati
- Y Zhang
- Y Zheng
- Y Zhu
- Y Zhu
- YB Chen
- YC Hou
- YH Liao
- YI Nakajima
- Ying Wang
- YN Gong
- Yoshihide Tsujimoto
- YS Cho
- Yufang Shi
- Z Cai
- Z Cai
- Z Wang
- Z Wang
- Z Xu
- Z You
- Z Zhang
- Z Zhong
- Zahra Zakeri
- ZG Liu
- ZN Oltvai
- ZT Schafer
- ZX Chen
- ZX Chen
- Publication venue
- Cell Death Differ
- Publication date
- 01/01/2018
- Field of study
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
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