Models for Type I X-Ray Bursts with Improved Nuclear Physics

Multi-zone models of Type I X-ray bursts are presented that use an adaptive nuclear reaction network of unprecedented size, up to 1300 isotopes. Sequences of up to 15 bursts are followed for two choices of accretion rate and metallicity. At 0.1 Eddington (and 0.02 Eddington for low metallicity), combined hydrogen-helium flashes occur. The rise times, shapes, and tails of these light curves are sensitive to the efficiency of nuclear burning at various waiting points along the rp-process path and these sensitivities are explored. The bursts show "compositional inertia", in that their properties depend on the fact that accretion occurs onto the ashes of previous bursts which contain left-over hydrogen, helium and CNO nuclei. This acts to reduce the sensitivity of burst properties to metallicity. For the accretion rates studied, only the first anomalous burst in one model produces nuclei as heavy as A=100, other bursts make chiefly nuclei with A~64. The amount of carbon remaining after hydrogen-helium bursts is typically <1% by mass, and decreases further as the ashes are periodically heated by subsequent bursts. At the lower accretion rate of 0.02 Eddington and solar metallicity, the bursts ignite in a hydrogen-free helium layer. At the base of this layer, up to 90% of the helium has already burned to carbon prior to the unstable ignition. These helium-ignited bursts have briefer, brighter light curves with shorter tails, very rapid rise times (<0.1 s), and ashes lighter than the iron group.Comment: Submitted to the Astrophysical Journal (42 pages; 27 figures

Interaction between neonatal vitamin A supplementation and timing of measles vaccination: a retrospective analysis of three randomized trials from Guinea-Bissau.

BACKGROUND: In Guinea-Bissau we conducted three trials of neonatal vitamin A supplementation (NVAS) from 2002 to 2008. None of the trials found a beneficial effect on mortality. From 2003 to 2007, an early measles vaccine (MV) trial was ongoing, randomizing children 1:2 to early MV at 4.5 months or no early MV, in addition to the usual MV at 9 months. We have previously found interactions between vitamin A and vaccines. OBJECTIVE: We investigated whether there were interactions between NVAS and early MV. DESIGN: We compared the mortality of NVAS and placebo recipients: first, from 4.5 to 8 months for children randomized to early MV or no early MV; and second, from 9 to 17 months in children who had received two MV or one MV. Mortality rates (MR) were compared in Cox models producing mortality rate ratios (MRR). RESULTS: A total of 5141 children were randomized to NVAS (N=3015) or placebo (N=2126) and were later randomized to early MV (N=1700) or no early MV (N=3441). Between 4.5 and 8 months, NVAS compared with placebo was associated with higher mortality in early MV recipients (MR=30 versus MR=0, p=0.01), but not in children who did not receive early MV (p for interaction between NVAS and early MV=0.03). From 9 to 17 months NVAS was not associated with mortality. Overall, from 4.5 to 17 months NVAS was associated with increased mortality in early MV recipients (Mortality rate ratio=5.39 (95% confidence interval: 1.62, 17.99)). CONCLUSIONS: These observations indicate that NVAS may interact with vaccines given several months later. This may have implications for the planning of future child intervention programs

Experimental measurements of the 15O(alpha,gamma)19Ne reaction rate and the stability of thermonuclear burning on accreting neutron stars

Neutron stars in close binary star systems often accrete matter from their companion stars. Thermonuclear ignition of the accreted material in the atmosphere of the neutron star leads to a thermonuclear explosion which is observed as an X-ray burst occurring periodically between hours and days depending on the accretion rate. The ignition conditions are characterized by a sensitive interplay between the accretion rate of the fuel supply and its depletion rate by nuclear burning in the hot CNO cycle and the rp-process. For accretion rates close to stable burning the burst ignition therefore depends critically on the hot CNO breakout reaction {sup 15}O({alpha}, {gamma}){sup 19}Ne that regulates the flow between the hot CNO cycle and the rapid proton capture process. Until recently, the {sup 15}O({alpha}, {gamma}){sup 19}Ne reaction rate was not known experimentally and the theoretical estimates carried significant uncertainties. In this paper we perform a parameter study of the uncertainty of this reaction rate and determine the astrophysical consequences of the first measurement of this reaction rate. Our results corroborate earlier predictions and show that theoretically burning remains unstable up to accretion rates near the Eddington limit, in contrast to astronomical observations

The cooling rate of neutron stars after thermonuclear shell flashes

Thermonuclear shell flashes on neutron stars are detected as bright X-ray bursts. Traditionally, their decay is modeled with an exponential function. However, this is not what theory predicts. The expected functional form for luminosities below the Eddington limit, at times when there is no significant nuclear burning, is a power law. We tested the exponential and power-law functional forms against the best data available: bursts measured with the high-throughput Proportional Counter Array (PCA) on board the Rossi X-ray Timing Explorer. We selected a sample of 35 'clean' and ordinary (i.e., shorter than a few minutes) bursts from 14 different neutron stars that 1) show a large dynamic range in luminosity, 2) are the least affected by disturbances by the accretion disk and 3) lack prolonged nuclear burning through the rp-process. We find indeed that for every burst a power law is a better description than an exponential function. We also find that the decay index is steep, 1.8 on average, and different for every burst. This may be explained by contributions from degenerate electrons and photons to the specific heat capacity of the ignited layer and by deviations from the Stefan-Boltzmann law due to changes in the opacity with density and temperature. Detailed verification of this explanation yields inconclusive results. While the values for the decay index are consistent, changes of it with the burst time scale, as a proxy of ignition depth, and with time are not supported by model calculations.Comment: 10 pages, 7 figures, recommended for publication in A&

The ClpXP protease is dispensable for degradation of unfolded proteins in <i>Staphylococcus aureus</i>

Abstract In living cells intracellular proteolysis is crucial for protein homeostasis, and ClpP proteases are conserved between eubacteria and the organelles of eukaryotic cells. In Staphylococcus aureus, ClpP associates to the substrate specificity factors, ClpX and ClpC forming two ClpP proteases, ClpXP and ClpCP. To address how individual ClpP proteases impact cell physiology, we constructed a S. aureus mutant expressing ClpX with an I265E substitution in the ClpP recognition tripeptide of ClpX. This mutant cannot degrade established ClpXP substrates confirming that the introduced amino acid substitution abolishes ClpXP activity. Phenotypic characterization of this mutant showed that ClpXP activity controls cell size and is required for growth at low temperature. Cells expressing the ClpXI265E variant, in contrast to cells lacking ClpP, are not sensitive to heat-stress and do not accumulate protein aggregates showing that ClpXP is dispensable for degradation of unfolded proteins in S. aureus. Consistent with this finding, transcriptomic profiling revealed strong induction of genes responding to protein folding stress in cells devoid of ClpP, but not in cells lacking only ClpXP. In the latter cells, highly upregulated loci include the urease operon, the pyrimidine biosynthesis operon, the betA-betB operon, and the pathogenicity island, SaPI5, while virulence genes were dramatically down-regulated

Nucleosynthesis in Early Neutrino Driven Winds

Nucleosynthesis in early neutrino winds is investigated. Presented is a brief overview of two recent problems of supernova nucleosynthesis. In the first part we investigate the effect of nuclear parameters on the synthesis of Mo92 and Mo94. Based on recent experimental results, we find that the proton rich winds of the model investigated here can not be the source of solar Mo92 and Mo94. In the second part we investigate the nucleosynthesis from neutron rich bubbles and show that they do not contribute to the overall nucleosynthesis.Comment: 4 pages, 4 figures, proceedings for CNR 2007 Compound-Nuclear Reactions and Related Topics Worksho