Innovation as a part of strategic management and enterprise competitiveness of petrochemical cluster

© 2016 Taylor & Francis Group, London.In this paper, we have investigated an innovative development of petrochemical cluster in the Republic of Tatarstan, the main trends and factors to improve its competitiveness through innovation were identified. It contains clarification of the notion of strategic management of innovative development of the petrochemical cluster, and the basic management practices that improve the investment and innovation activity of petrochemical industries were considered

Innovation as a part of strategic management and enterprise competitiveness of petrochemical cluster

© 2016 Taylor & Francis Group, London.In this paper, we have investigated an innovative development of petrochemical cluster in the Republic of Tatarstan, the main trends and factors to improve its competitiveness through innovation were identified. It contains clarification of the notion of strategic management of innovative development of the petrochemical cluster, and the basic management practices that improve the investment and innovation activity of petrochemical industries were considered

Innovation as a part of strategic management and enterprise competitiveness of petrochemical cluster

© 2016 Taylor & Francis Group, London.In this paper, we have investigated an innovative development of petrochemical cluster in the Republic of Tatarstan, the main trends and factors to improve its competitiveness through innovation were identified. It contains clarification of the notion of strategic management of innovative development of the petrochemical cluster, and the basic management practices that improve the investment and innovation activity of petrochemical industries were considered

Innovation as a part of strategic management and enterprise competitiveness of petrochemical cluster

© 2016 Taylor & Francis Group, London.In this paper, we have investigated an innovative development of petrochemical cluster in the Republic of Tatarstan, the main trends and factors to improve its competitiveness through innovation were identified. It contains clarification of the notion of strategic management of innovative development of the petrochemical cluster, and the basic management practices that improve the investment and innovation activity of petrochemical industries were considered

Antioxidant activity in the leaves of Melilotus albus and Trifolium medium from man-made disturbed habitats in the Middle Urals under the influence of copper

Physiological mechanisms of adaptation to copper-induced stress in two widespread legume plants, white sweet clover (Melilotus albus Merik.) and zigzag clover (Trifolium medium L.), growing in habitats differing in the man-made pollution. An antioxidant plant defense system was activated in response to 10 mM CuSO 4, which is a stress factor. Specific biochemical features related to adaptation to soil contamination with copper were observed in tested plant species. Superoxide dismutase was activated in response to stress in both species from various habitats. M. albus from the impact zone manifested the better capacity of proline accumulation as compared with plants from less polluted habitats. T. medium plants from the impact zone contained more active peroxidase. It was suggested that plants growing for a long time under stressful conditions manifest the greater tolerance to copper ions than plants, which did not experience stress or were subjected to the milder stress. © 2012 Pleiades Publishing, Ltd

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.

DNA polymerase δ, whose catalytic subunit is encoded by POLD1, is responsible for lagging-strand DNA synthesis during DNA replication. It carries out this synthesis with high fidelity owing to its intrinsic 3'- to 5'-exonuclease activity, which confers proofreading ability. Missense mutations affecting the exonuclease domain of POLD1 have recently been shown to predispose to colorectal and endometrial cancers. Here we report a recurring heterozygous single-codon deletion in POLD1 affecting the polymerase active site that abolishes DNA polymerase activity but only mildly impairs 3'- to 5'-exonuclease activity. This mutation causes a distinct multisystem disorder that includes subcutaneous lipodystrophy, deafness, mandibular hypoplasia and hypogonadism in males. This discovery suggests that perturbing the function of the ubiquitously expressed POLD1 polymerase has unexpectedly tissue-specific effects in humans and argues for an important role for POLD1 function in adipose tissue homeostasis