Descartes, corpuscles and reductionism : mechanism and systems in Descartes' physiology

I argue that Descartes explains physiology in terms of whole systems, and not in terms of the size, shape and motion of tiny corpuscles (corpuscular mechanics). It is a standard, entrenched view that Descartes’s proper means of explanation in the natural world is through strict reduction to corpuscular mechanics. This view is bolstered by a handful of corpuscular-mechanical explanations in Descartes’s physics, which have been taken to be representative of his treatment of all natural phenomena. However, Descartes’s explanations of the ‘principal parts’ of physiology do not follow the corpuscular–mechanical pattern. Des Chene (2001) has identified systems in Descartes’s account of physiology, but takes them ultimately to reduce down to the corpuscle level. I argue that they do not. Rather, Descartes maintains entire systems, with components selected from multiple levels of organisation, in order to construct more complete explanations than corpuscular mechanics alone would allow

The Immanent Contingency of Physical Laws in Leibniz’s Dynamics

This paper focuses on Leibniz’s conception of modality and its application to the issue of natural laws. The core of Leibniz’s investigation of the modality of natural laws lays in the distinction between necessary, geometrical laws on the one hand, and contingent, physical laws of nature on the other. For Leibniz, the contingency of physical laws entailed the assumption of the existence of an additional form of causality beyond mechanical or efficient ones. While geometrical truths, being necessary, do not require the use of the principle of sufficient reason, physical laws are not strictly determined by geometry and therefore are logically distinct from geometrical laws. As a consequence, the set of laws that regulate the physical laws could have been created otherwise by God. However, in addition to this, the contingency of natural laws does not consist only in the fact that God has chosen them over other possible ones. On the contrary, Leibniz understood the status of natural laws as arising from the action internal to physical substances. Hence the actuality of physical laws results from a causal power that is inherent to substances rather than being the mere consequence of the way God arranged the relations between physical objects. Focusing on three instances of Leibniz’s treatment of contingency in physics, this paper argues that, in order to account for the contingency of physical laws, Leibniz maintained that final causes, in addition to efficient and mechanical ones, must operate in physical processes and operations

Relational interpretation of the wave function and a possible way around Bell's theorem

The famous ``spooky action at a distance'' in the EPR-szenario is shown to be a local interaction, once entanglement is interpreted as a kind of ``nearest neighbor'' relation among quantum systems. Furthermore, the wave function itself is interpreted as encoding the ``nearest neighbor'' relations between a quantum system and spatial points. This interpretation becomes natural, if we view space and distance in terms of relations among spatial points. Therefore, ``position'' becomes a purely relational concept. This relational picture leads to a new perspective onto the quantum mechanical formalism, where many of the ``weird'' aspects, like the particle-wave duality, the non-locality of entanglement, or the ``mystery'' of the double-slit experiment, disappear. Furthermore, this picture cirumvents the restrictions set by Bell's inequalities, i.e., a possible (realistic) hidden variable theory based on these concepts can be local and at the same time reproduce the results of quantum mechanics.Comment: Accepted for publication in "International Journal of Theoretical Physics

The Network Analysis of Urban Streets: A Primal Approach

The network metaphor in the analysis of urban and territorial cases has a long tradition especially in transportation/land-use planning and economic geography. More recently, urban design has brought its contribution by means of the "space syntax" methodology. All these approaches, though under different terms like accessibility, proximity, integration,connectivity, cost or effort, focus on the idea that some places (or streets) are more important than others because they are more central. The study of centrality in complex systems,however, originated in other scientific areas, namely in structural sociology, well before its use in urban studies; moreover, as a structural property of the system, centrality has never been extensively investigated metrically in geographic networks as it has been topologically in a wide range of other relational networks like social, biological or technological. After two previous works on some structural properties of the dual and primal graph representations of urban street networks (Porta et al. cond-mat/0411241; Crucitti et al. physics/0504163), in this paper we provide an in-depth investigation of centrality in the primal approach as compared to the dual one, with a special focus on potentials for urban design.Comment: 19 page, 4 figures. Paper related to the paper "The Network Analysis of Urban Streets: A Dual Approach" cond-mat/041124

Embodied cognitive ecosophy: the relationship of mind, body, meaning and ecology

The concept of embodied cognition has had a major impact in a number of disciplines. The extent of its consequences on general knowledge and epistemology are still being explored. Embodied cognition in human geography has its own traditions and discourses but these have become somewhat isolated in the discipline itself. This paper argues that findings in other disciplines are of value in reconceptualising embodied cognition in human geography and this is explored by reconsidering the concept of ecosophy. Criticisms of ecosophy as a theory are considered and recent work in embodied cognition is applied to consider how such criticisms might be addressed. An updated conceptualisation is proposed, the embodied cognitive ecosophy, and three characteristics arising from this criticism and synthesis are presented with a view to inform future discussions of ecosophy and emotional geography

Personal and sub-personal: a defence of Dennett's early distinction

Since 1969, when Dennett introduced a distinction between personal and sub‐personal levels of explanation, many philosophers have used ‘sub‐personal’ very loosely, and Dennett himself has abandoned a view of the personal level as genuinely autonomous. I recommend a position in which Dennett's original distinction is crucial, by arguing that the phenomenon called mental causation is on view only at the properly personal level. If one retains the commit‐’ ments incurred by Dennett's early distinction, then one has a satisfactory anti‐physicalistic, anti‐dualist philosophy of mind. It neither interferes with the projects of sub‐personal psychology, nor encourages ; instrumentalism at the personal level. People lose sight of Dennett’s personal/sub-personal distinction because they free it from its philosophical moorings. A distinction that serves a philosophical purpose is typically rooted in doctrine; it cannot be lifted out of context and continue to do its work. So I shall start from Dennett’s distinction as I read it in its original context. And when I speak of ‘the distinction’, I mean to point not only towards the terms that Dennett first used to define it but also towards the philosophical setting within which its work was cut out

“I had no idea this shame piece was in me”: couple and family therapists’ experience with learning an evidence-based practice

This study reports on the experience of shame while learning an evidence-based approach to working with couples or families. Couple and family therapists were interviewed about their experience with learning and using an evidence-based practice (EBP) and the data was analyzed using a phenomenological approach called interpretative phenomenological analysis. The theme of shame emerged from a number of research participants as part of their development with the EBP they were integrating into their practice. Starting with an exploration of the participants’ experiences and the impact of shame, the paper will then link these experiences with the psychological and sociological research literature about sham

Bregman Voronoi Diagrams: Properties, Algorithms and Applications

The Voronoi diagram of a finite set of objects is a fundamental geometric structure that subdivides the embedding space into regions, each region consisting of the points that are closer to a given object than to the others. We may define many variants of Voronoi diagrams depending on the class of objects, the distance functions and the embedding space. In this paper, we investigate a framework for defining and building Voronoi diagrams for a broad class of distance functions called Bregman divergences. Bregman divergences include not only the traditional (squared) Euclidean distance but also various divergence measures based on entropic functions. Accordingly, Bregman Voronoi diagrams allow to define information-theoretic Voronoi diagrams in statistical parametric spaces based on the relative entropy of distributions. We define several types of Bregman diagrams, establish correspondences between those diagrams (using the Legendre transformation), and show how to compute them efficiently. We also introduce extensions of these diagrams, e.g. k-order and k-bag Bregman Voronoi diagrams, and introduce Bregman triangulations of a set of points and their connexion with Bregman Voronoi diagrams. We show that these triangulations capture many of the properties of the celebrated Delaunay triangulation. Finally, we give some applications of Bregman Voronoi diagrams which are of interest in the context of computational geometry and machine learning.Comment: Extend the proceedings abstract of SODA 2007 (46 pages, 15 figures

Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences

BACKGROUND: Elevated urinary excretion of orotic acid is associated with treatable disorders of the urea cycle and pyrimidine metabolism. Establishing the correct and timely diagnosis in a patient with orotic aciduria is key to effective treatment. Uridine monophosphate synthase is involved in de novo pyrimidine synthesis. Uridine monophosphate synthase deficiency (or hereditary orotic aciduria), due to biallelic mutations in UMPS, is a rare condition presenting with megaloblastic anemia in the first months of life. If not treated with the pyrimidine precursor uridine, neutropenia, failure to thrive, growth retardation, developmental delay, and intellectual disability may ensue. METHODS AND RESULTS: We identified mild and isolated orotic aciduria in 11 unrelated individuals with diverse clinical signs and symptoms, the most common denominator being intellectual disability/developmental delay. Of note, none had blood count abnormalities, relevant hyperammonemia or altered plasma amino acid profile. All individuals were found to have heterozygous alterations in UMPS. Four of these variants were predicted to be null alleles with complete loss of function. The remaining variants were missense changes and predicted to be damaging to the normal encoded protein. Interestingly, family screening revealed heterozygous UMPS variants in combination with mild orotic aciduria in 19 clinically asymptomatic family members. CONCLUSIONS: We therefore conclude that heterozygous UMPS-mutations can lead to mild and isolated orotic aciduria without clinical consequence. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria. The discovery of heterozygotes manifesting clinical symptoms such as hypotonia and developmental delay are likely due to ascertainment bias