Actuaciones arqueologicas en Cantabria, 1984-1999

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Actuaciones arqueologicas en Cantabria, 1987-1999. Arqueologia de gestion

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme

A phase II trial was instigated to investigate the antitumour activity, the safety and the pharmacokinetic parameters of RFS2000, a recently identified oral topoisomerase I inhibitor, given once daily (1.5 mg/m(2)/day) as first-line chemotherapy treatment for patients with advanced glioblastoma multiforme (GBM). Between 9 March and 15 September 2000, 17 patients were entered onto the trial. 15 patients were considered eligible. A total of 49 cycles (range 1-8) were administered. Grade 3-4 toxicity was observed in 5 patients. Neutropenia and thrombocytopenia were common toxicities. Pharmacokinetic analysis showed that 9-nitro camptothecin (9-NC) could be detected in the plasma and is progressively converted into 9-amino-camptothecin (9-AC). The response rate was poor, with 5 patients experiencing tumour stabilisation and 10 progressing. Thus, the results do not support the further evaluation of RFS2000 as a single agent in patients with recurrent GBM

A latent historiography? The case of psychiatry in Britain, 1500-1820

Both empirically and interpretively, extant histories of psychiatry reveal a vastly greater degree of difference among themselves than historical accounts of any other field. Scholarship focuses on the period after 1800 and the same is true of historiographical reviews; those of early modern British psychiatry are often brief literature studies. This article sets out in depth the development of this rich and varied branch of history since the 1950s, exploring the many different approaches that have contributed to understanding the mad and how they were treated. Social, cultural, philosophical, religious, and intellectual historians have contributed as much as historians of science and medicine to understanding an enduring topic of fascination: ‘disorders of consciousness and conduct’ and their context. Appreciating the sometimes unacknowledged lineages of the subject and the personal histories of scholars (roots and routes) makes it easier to understand the past, present, and future of the history of psychiatry. The article explores European and North American influences as well as British traditions, looking at both the main currents of historiographical change and developments particular to the history of psychiatry.Publisher PDFPeer reviewe