A New AR Interaction Paradigm for Collaborative TeleAssistance system: The P.O.A

International audienceIn this paper, we propose a prototype of a collaborative teleassistance system for mechanical repairs based on Augmented Reality (AR). This technology is generally used to implement specific assistance applications for users, which consist of providing all the information, known as augmentations, required to perform a task. For teletransmission applications, operators are equipped with a wearable computer and a technical support expert can accurately visualize what the operator sees thanks to the teletransmission of the corresponding video stream. Within the framework of remote communication, our aim is to foster collaboration, especially informal collaboration, between the operator and the expert in order to make teleassistance easier and more efficient. To do this we rely on classical repair technologies and on collaborative systems to introduce a new human-machine interaction: the Picking Outlining Adding interaction (POA interaction). With this new interaction paradigm, technical information is provided by directly Picking, Outlining and Adding information to an item in an operator's video stream

Pharmacokinetics of Intravenously Administered Levofloxacin in Men and Women

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90350/1/phco.2005.25.10.1310.pd

A Golgi-localized Hexose Transporter Is Involved in Heterotrimeric G Protein-mediated Early Development in Arabidopsis

Signal transduction involving heterotrimeric G proteins is universal among fungi, animals, and plants. In plants and fungi, the best understood function for the G protein complex is its modulation of cell proliferation and one of several important signals that are known to modulate the rate at which these cells proliferate is d-glucose. Arabidopsis thaliana seedlings lacking the β subunit (AGB1) of the G protein complex have altered cell division in the hypocotyl and are d-glucose hypersensitive. With the aim to discover new elements in G protein signaling, we screened for gain-of-function suppressors of altered cell proliferation during early development in the agb1-2 mutant background. One agb1-2-dependent suppressor, designated sgb1-1D for suppressor of G protein beta1 (agb1-2), restored to wild type the altered cell division in the hypocotyl and sugar hypersensitivity of the agb1-2 mutant. Consistent with AGB1 localization, SGB1 is found at the highest steady-state level in tissues with active cell division, and this level increases in hypocotyls when grown on d-glucose and sucrose. SGB1 is shown here to be a Golgi-localized hexose transporter and acts genetically with AGB1 in early seedling development

Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease

Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary considerably. Here we report on a novel targeted aspa mouse mutant expressing the bacterial β-Galactosidase (lacZ) gene under the control of the aspa regulatory elements. X-Gal staining in known ASPA expression domains confirms the integrity of the modified locus in heterozygous aspa lacZ-knockin (aspalacZ/+) mice. In addition, abundant ASPA expression was detected in Schwann cells. Homozygous (aspalacZ/lacZ) mutants are ASPA-deficient, show CD-like histopathology and moderate neurological impairment with behavioural deficits that are more pronounced in aspalacZ/lacZ males than females. Non-invasive ultrahigh field proton magnetic resonance spectroscopy revealed increased levels of NAA, myo-inositol and taurine in the aspalacZ/lacZ brain. Spongy degeneration was prominent in hippocampus, thalamus, brain stem, and cerebellum, whereas white matter of optic nerve and corpus callosum was spared. Intracellular vacuolisation in astrocytes coincides with axonal swellings in cerebellum and brain stem of aspalacZ/lacZ mutants indicating that astroglia may act as an osmolyte buffer in the aspa-deficient CNS. In summary, the aspalacZ mouse is an accurate model of CD and an important tool to identify novel aspects of its complex pathology

MRI of the kidney—state of the art

Ultrasound and computed tomography (CT) are modalities of first choice in renal imaging. Until now, magnetic resonance imaging (MRI) has mainly been used as a problem-solving technique. MRI has the advantage of superior soft-tissue contrast, which provides a powerful tool in the detection and characterization of renal lesions. The MRI features of common and less common renal lesions are discussed as well as the evaluation of the spread of malignant lesions and preoperative assessment. MR urography technique and applications are discussed as well as the role of MRI in the evaluation of potential kidney donors. Furthermore the advances in functional MRI of the kidney are highlighted

CYLINDRICITY - A WELL KNOWN PROBLEM AND NEW SOLUTIONS

The past twenty years have seen a continued increase in importance of computer aided measurement techniques as a means to control industrial production. At the same time the basic definitions governing design, production and quality control of workpieces have undergone first steps of international harmonization and standardization. Focal points of interest included the definitions of nominal, real and substitute geometrical features. The cylinder is a characteristic example of feature both on the side of design and production as well as on the side of measurement