MindDial: Belief Dynamics Tracking with Theory-of-Mind Modeling for Situated Neural Dialogue Generation

Humans talk in free-form while negotiating the expressed meanings or common ground. Despite the impressive conversational abilities of the large generative language models, they do not consider the individual differences in contextual understanding in a shared situated environment. In this work, we propose MindDial, a novel conversational framework that can generate situated free-form responses to negotiate common ground. We design an explicit mind module that can track three-level beliefs -- the speaker's belief, the speaker's prediction of the listener's belief, and the common belief based on the gap between the first two. Then the speaking act classification head will decide to continue to talk, end this turn, or take task-related action. We augment a common ground alignment dataset MutualFriend with belief dynamics annotation, of which the goal is to find a single mutual friend based on the free chat between two agents. Experiments show that our model with mental state modeling can resemble human responses when aligning common ground meanwhile mimic the natural human conversation flow. The ablation study further validates the third-level common belief can aggregate information of the first and second-order beliefs and align common ground more efficiently

Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer.

Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomics, an emerging noninvasive technology using medical imaging analysis and data mining methodology, has been adopted to the area of cancer diagnostics in recent years. Its potential application in response assessment for cancer treatment has also drawn considerable attention. Radiomics seeks to extract a large amount of valuable information from patients' medical images (both pretreatment and follow-up images) and quantitatively correlate image features with diagnostic and therapeutic outcomes. Radiomics relies on computers to identify and analyze vast amounts of quantitative image features that were previously overlooked, unmanageable, or failed to be identified (and recorded) by human eyes. The research area has been focusing on the predictive accuracy of pretreatment features for outcome and response and the early discovery of signs of tumor response, recurrence, distant metastasis, radiation-induced lung injury, death, and other outcomes, respectively. This review summarized the application of radiomics in response assessments in radiotherapy and chemotherapy for non-small cell lung cancer, including image acquisition/reconstruction, region of interest definition/segmentation, feature extraction, and feature selection and classification. The literature search for references of this article includes PubMed peer-reviewed publications over the last 10 years on the topics of radiomics, textural features, radiotherapy, chemotherapy, lung cancer, and response assessment. Summary tables of radiomics in response assessment and treatment outcome prediction in radiation oncology have been developed based on the comprehensive review of the literature

"Dose of the day" based on cone beam computed tomography and deformable image registration for lung cancer radiotherapy.

PURPOSE:Adaptive radiotherapy (ART) has potential to reduce toxicity and facilitate safe dose escalation. Dose calculations with the planning CT deformed to cone beam CT (CBCT) have shown promise for estimating the "dose of the day". The purpose of this study is to investigate the "dose of the day" calculation accuracy based on CBCT and deformable image registration (DIR) for lung cancer radiotherapy. METHODS:A total of 12 lung cancer patients were identified, for which daily CBCT imaging was performed for treatment positioning. A re-planning CT (rCT) was acquired after 20 Gy for all patients. A virtual CT (vCT) was created by deforming initial planning CT (pCT) to the simulated CBCT that was generated from deforming CBCT to rCT acquired on the same day. Treatment beams from the initial plan were copied to the vCT and rCT for dose calculation. Dosimetric agreement between vCT-based and rCT-based accumulated doses was evaluated using the Bland-Altman analysis. RESULTS:Mean differences in dose-volume metrics between vCT and rCT were smaller than 1.5%, and most discrepancies fell within the range of ± 5% for the target volume, lung, esophagus, and heart. For spinal cord Dmax , a large mean difference of -5.55% was observed, which was largely attributed to very limited CBCT image quality (e.g., truncation artifacts). CONCLUSION:This study demonstrated a reasonable agreement in dose-volume metrics between dose accumulation based on vCT and rCT, with the exception for cases with poor CBCT image quality. These findings suggest potential utility of vCT for providing a reasonable estimate of the "dose of the day", and thus facilitating the process of ART for lung cancer

Theoretical analysis of low GWP mixture R600a/R1234ze as a possible alternative to R600a in domestic refrigerators

In this study, a thermodynamic analysis of R600a and R600a/R134ze mixture at three compositions of 0%, 20% and 50% R1234ze is measured in a domestic refrigerator. The main purpose of this study is to theoretically verify the possibility of applying the mixture R600a/R1234ze in large capacity refrigerator. The performance has been assessed for different condensing temperatures between 30 and 50? with constant -20? evaporating temperature .The performance of the refrigerator was compared in terms of volumetric cooling capacity, COP (coefficient of performance), compression ratio and compressor discharge temperature. The results show that the volumetric cooling capacity, COP, compressor power consumption and compressor discharge temperature of R600a/R1234ze mixture are similar to those of pure R600a,so that R600a compressor can be used for R600a/R1234ze mixture without any modifications. The amount charge of the mixture R600a/R1234ze is slight lower than that of R600a in the same equipment. Flammability decreases in R600a/R1234ze mixtures with increasing fractions of R1234ze. This is an desirable characteristic because of the large charge requirement of large refrigeration systems

LLM-RadJudge: Achieving Radiologist-Level Evaluation for X-Ray Report Generation

Evaluating generated radiology reports is crucial for the development of radiology AI, but existing metrics fail to reflect the task's clinical requirements. This study proposes a novel evaluation framework using large language models (LLMs) to compare radiology reports for assessment. We compare the performance of various LLMs and demonstrate that, when using GPT-4, our proposed metric achieves evaluation consistency close to that of radiologists. Furthermore, to reduce costs and improve accessibility, making this method practical, we construct a dataset using LLM evaluation results and perform knowledge distillation to train a smaller model. The distilled model achieves evaluation capabilities comparable to GPT-4. Our framework and distilled model offer an accessible and efficient evaluation method for radiology report generation, facilitating the development of more clinically relevant models. The model will be further open-sourced and accessible.Comment: 11 pages, 6 figure

Converting Treatment Plans From Helical Tomotherapy to L-Shape Linac: Clinical Workflow and Dosimetric Evaluation.

This work evaluated a commercial fallback planning workflow designed to provide cross-platform treatment planning and delivery. A total of 27 helical tomotherapy intensity-modulated radiotherapy plans covering 4 anatomical sites were selected, including 7 brain, 5 unilateral head and neck, 5 bilateral head and neck, 5 pelvis, and 5 prostate cases. All helical tomotherapy plans were converted to 7-field/9-field intensity-modulated radiotherapy and volumetric-modulated radiotherapy plans through fallback dose-mimicking algorithm using a 6-MV beam model. The planning target volume (PTV) coverage ( D1, D99, and homogeneity index) and organs at risk dose constraints were evaluated and compared. Overall, all 3 techniques resulted in relatively inferior target dose coverage compared to helical tomotherapy plans, with higher homogeneity index and maximum dose. The organs at risk dose ratio of fallback to helical tomotherapy plans covered a wide spectrum, from 0.87 to 1.11 on average for all sites, with fallback plans being superior for brain, pelvis, and prostate sites. The quality of fallback plans depends on the delivery technique, field numbers, and angles, as well as user selection of structures for organs at risk. In actual clinical scenario, fallback plans would typically be needed for 1 to 5 fractions of a treatment course in the event of machine breakdown. Our results suggested that <1% dose variance can be introduced in target coverage and/or organs at risk from fallback plans. The presented clinical workflow showed that the fallback plan generation typically takes 10 to 20 minutes per case. Fallback planning provides an expeditious and effective strategy for transferring patients cross platforms, and minimizing the untold risk of a patient missing treatment(s)

IPoD: Implicit Field Learning with Point Diffusion for Generalizable 3D Object Reconstruction from Single RGB-D Images

Generalizable 3D object reconstruction from single-view RGB-D images remains a challenging task, particularly with real-world data. Current state-of-the-art methods develop Transformer-based implicit field learning, necessitating an intensive learning paradigm that requires dense query-supervision uniformly sampled throughout the entire space. We propose a novel approach, IPoD, which harmonizes implicit field learning with point diffusion. This approach treats the query points for implicit field learning as a noisy point cloud for iterative denoising, allowing for their dynamic adaptation to the target object shape. Such adaptive query points harness diffusion learning's capability for coarse shape recovery and also enhances the implicit representation's ability to delineate finer details. Besides, an additional self-conditioning mechanism is designed to use implicit predictions as the guidance of diffusion learning, leading to a cooperative system. Experiments conducted on the CO3D-v2 dataset affirm the superiority of IPoD, achieving 7.8% improvement in F-score and 28.6% in Chamfer distance over existing methods. The generalizability of IPoD is also demonstrated on the MVImgNet dataset. Our project page is at https://yushuang-wu.github.io/IPoD.Comment: CVPR 202

NeuroD2 regulates the development of hippocampal mossy fiber synapses

<p>Abstract</p> <p>Background</p> <p>The assembly of neural circuits requires the concerted action of both genetically determined and activity-dependent mechanisms. Calcium-regulated transcription may link these processes, but the influence of specific transcription factors on the differentiation of synapse-specific properties is poorly understood. Here we characterize the influence of NeuroD2, a calcium-dependent transcription factor, in regulating the structural and functional maturation of the hippocampal mossy fiber (MF) synapse.</p> <p>Results</p> <p>Using NeuroD2 null mice and <it>in vivo </it>lentivirus-mediated gene knockdown, we demonstrate a critical role for NeuroD2 in the formation of CA3 dendritic spines receiving MF inputs. We also use electrophysiological recordings from CA3 neurons while stimulating MF axons to show that NeuroD2 regulates the differentiation of functional properties at the MF synapse. Finally, we find that NeuroD2 regulates PSD95 expression in hippocampal neurons and that PSD95 loss of function <it>in vivo </it>reproduces CA3 neuron spine defects observed in NeuroD2 null mice.</p> <p>Conclusion</p> <p>These experiments identify NeuroD2 as a key transcription factor that regulates the structural and functional differentiation of MF synapses <it>in vivo</it>.</p