Formulation of Equations of Motion for a Simply Supported Bridge under a Moving Railway Freight Vehicle

Based on energy approach, the equations of motion in matrix form for the railway freight vehicle-bridge interaction system are derived, in which the dynamic contact forces between vehicle and bridge are considered as internal forces. The freight vehicle is modelled as a multi-rigid-body system, which comprises one car body, two bogie frames and four wheelsets. The bogie frame is linked with the car body through spring-dashpot suspension systems, and the bogie frame is rigidly linked with wheelsets. The bridge deck, together with railway track resting on bridge, is modelled as a simply supported Bernoulli-Euler beam and its deflection is described by superimposing modes. The direct time integration method is applied to obtain the dynamic response of the vehicle-bridge interaction system at each time step. A computer program has been developed for analyzing this system. The correctness of the proposed procedure is confirmed by one numerical example. The effect of different beam mode numbers and various surface irregularities of beam on the dynamic responses of the vehicle-bridge interaction system are investigated

Tetra­aqua­bis[2-(2,4-dichloro­phen­oxy)acetato]nickel(II)

In the title complex, [Ni(C8H5Cl2O3)2(H2O)4], the NiII atom (site symmetry ) adopts a slightly distorted NiO6 octa­hedral coordination. An intra­molecular O—H⋯O hydrogen bond helps to establish the conformation. In the crystal, further O—H⋯O hydrogen bonds link the mol­ecules

Preparation and Enhancement of Thermal Conductivity of Heat Transfer Oil-Based MoS 2

The lipophilic MoS2 nanoparticles are synthesized by surface modification with stearic acid (SA). The heat transfer oil-based nanofluids, with the mass fraction of lipophilic nanoparticles varying from 0.25% up to 1.0%, are prepared and their thermal conductivity is determined at temperatures ranging from 40 to 200°C using an apparatus based on the laser flash method. It has been found that the nanofluids have higher thermal conductivity and the thermal conductivity enhancement increased not only with increasing mass fraction of nanoparticles, but also with increasing temperature in the range 40–180°C The results show a 38.7% enhancement of the thermal conductivity of MoS2 nanofluid with only 1.0% mass fraction at 180°C

Electro-acupuncture promotes survival, differentiation of the bone marrow mesenchymal stem cells as well as functional recovery in the spinal cord-transected rats

<p>Abstract</p> <p>Background</p> <p>Bone marrow mesenchymal stem cells (MSCs) are one of the potential tools for treatment of the spinal cord injury; however, the survival and differentiation of MSCs in an injured spinal cord still need to be improved. In the present study, we investigated whether <it>Governor Vessel </it>electro-acupuncture (EA) could efficiently promote bone marrow mesenchymal stem cells (MSCs) survival and differentiation, axonal regeneration and finally, functional recovery in the transected spinal cord.</p> <p>Results</p> <p>The spinal cords of adult Sprague-Dawley (SD) rats were completely transected at T10, five experimental groups were performed: 1. sham operated control (Sham-control); 2. operated control (Op-control); 3. electro-acupuncture treatment (EA); 4. MSCs transplantation (MSCs); and 5. MSCs transplantation combined with electro-acupuncture (MSCs+EA). After 2-8 weeks of MSCs transplantation plus EA treatment, we found that the neurotrophin-3 (NT-3), cAMP level, the differentiation of MSCs, the 5-HT positive and CGRP positive nerve fibers in the lesion site and nearby tissue of injured spinal cord were significantly increased in the MSCs+EA group as compared to the group of the MSCs transplantation or the EA treated alone. Furthermore, behavioral test and spinal cord evoked potentials detection demonstrated a significantly functional recovery in the MSCs +EA group.</p> <p>Conclusion</p> <p>These results suggest that EA treatment may promote grafted MSCs survival and differentiation; MSCs transplantation combined with EA treatment could promote axonal regeneration and partial locomotor functional recovery in the transected spinal cord in rats and indicate a promising avenue of treatment of spinal cord injury.</p

Obtaining SF-6D utilities from FACT-H&N in thyroid carcinoma patients: development and results from a mapping study

ObjectiveThere is limited evidence for mapping clinical tools to preference-based generic tools in the Chinese thyroid cancer patient population. The current study aims to map the FACT-H&amp;N (Functional Assessment of Cancer Therapy-Head and Neck Cancer) to the SF-6D (Short Form Six-Dimension), which will inform future cost-utility analyses related to thyroid cancer treatment.MethodsA total of 1050 participants who completed the FACT-H&amp;N and SF-6D questionnaires were included in the analysis. Four methods of direct and indirect mapping were estimated: OLS regression, Tobit regression, ordered probit regression, and beta mixture regression. We evaluated the predictive performance in terms of root mean square error (RMSE), mean absolute error (MAE), concordance correlation coefficient (CCC), Akaike information criterion (AIC) and Bayesian information criterion (BIC) and the correlation between the observed and predicted SF-6D scores.ResultsThe mean value of SF-6D was 0.690 (SD = 0.128). The RMSE values for the fivefold cross-validation as well as the 30% random sample validation for multiple models in this study were 0.0833-0.0909, MAE values were 0.0676-0.0782, and CCC values were 0.6940-0.7161. SF-6D utility scores were best predicted by a regression model consisting of the total score of each dimension of the FACT-H&amp;N, the square of the total score of each dimension, and covariates including age and gender. We proposed to use direct mapping (OLS regression) and indirect mapping (ordered probit regression) to establish a mapping model of FACT-H&amp;N to SF-6D. The mean SF-6D and cumulative distribution functions simulated from the recommended mapping algorithm generally matched the observed ones.ConclusionsIn the absence of preference-based quality of life tools, obtaining the health status utility of thyroid cancer patients from directly mapped OLS regression and indirectly mapped ordered probit regression is an effective alternative

Understanding the Kinetic Energy deposition within Molecular Clouds

According to the structures traced by $^{13}$CO spectral lines within the $^{12}$CO molecular clouds (MCs), we investigate the contributions of their internal gas motions and relative motions to the total velocity dispersions of $^{12}$CO MCs. Our samples of 2851 $^{12}$CO MCs harbor a total of 9556 individual $^{13}$CO structures, among which 1848 MCs ($\sim$ 65$\%$) have one individual $^{13}$CO structure and the other 1003 MCs ($\sim$ 35$\%$) have multiple $^{13}$CO structures. We find that the contribution of the relative motion between $^{13}$CO structures ($\sigma_{\rm ^{13}CO, re}$) is larger than that from their internal gas motion ($\sigma_{\rm ^{13}CO, in}$) in $\sim$ 62$\%$ of 1003 MCs in the `multiple' regime. In addition, we find the $\sigma_{\rm ^{13}CO, re}$ tends to increase with the total velocity dispersion($\sigma_{\rm ^{12}CO, tot}$) in our samples, especially for the MCs having multiple $^{13}$CO structures. This result provides a manifestation of the macro-turbulent within MCs, which gradually becomes the dominant way to store the kinetic energy along with the development of MC scales.Comment: 15 pages, 13 figures, accepted for publication in Ap

CO Emission Delineating the Interface between the Milky Way Nuclear Wind Cavity and the Gaseous Disk

Based on the MWISP survey, we study high-z CO emission toward the tangent points, in which the distances of the molecular clouds (MCs) are well determined. In the region of l=12-26 deg and |b|<5.1 deg, a total of 321 MCs with |z|> 110 pc are identified, of which nearly 30 extreme high-z MCs (EHMCs at |z|> 260 pc) are concentrated in a narrow region of R_GC=2.6-3.1 kpc. The EHMC concentrations, together with other high-z MCs at R_GC=2.3-2.6 kpc, constitute molecular crater-wall structures surrounding the edges of the HI voids that are physically associated with the Fermi bubbles. Intriguingly, some large high-z MCs, which lie in the crater-walls above and below the Galactic plane, show cometary structures with the head toward the plane, favouring the scenario that the entrained molecular gas moves with the multi-phase flows from the plane to the high-z regions. We suggest that the Milky Way nuclear wind has a significant impact on the Galactic gaseous disk. The powerful nuclear wind at ~3-6 Myr ago is likely responsible for the observational features, (1) the enhanced CO gas lying in the edges of the HI voids, (2) the deficiency of atomic and molecular gas within R_GC<3 kpc, (3) the possible connection between the EHMC concentrations and the 3-kpc arm, and (4) the elongated high-z MCs with the tail pointing away from the Galactic plane.Comment: 27 pages, 7 Figures, 1 Table. To appear in ApJ. Comments are welcome