2-(Dibutyl­amino)-3-(4-fluoro­phen­yl)-5,6,7,8-tetra­hydro-7-methyl-6,8-di­phenyl­pyridine­[3′,4′:2,3]thieno[5,4-d]pyrimidin-4(3H)-one

In the crystal structure of the title compound, C36H39FN4OS, the two fused rings of the thienopyrimidine system are coplanar. The 4-fluoro­phenyl ring is twisted with respect to the heterocyclic pyrimidinone ring by 67.21 (14)°. The piperidine ring shows a half-chair conformation. One of the n-butyl chains is disordered equally over two sites. The crystal packing is stabilized by C—H⋯O hydrogen bonds

An Effective On-line Polymer Characterization Technique by Using SALS Image Processing Software and Wavelet Analysis

This paper describes an effective on-line polymer characterization technique by using small-angle light-scattering (SALS) image processing software and wavelet analysis. The phenomenon of small-angle light scattering has been applied to give information about transparent structures on morphology. Real-time visualization of various scattered light image and light intensity matrices is performed by the optical image real-time processing software for SALS. The software can measure the signal intensity of light scattering images, draw the frequency-intensity curves and the amplitude-intensity curves to indicate the variation of the intensity of scattered light in different processing conditions, and estimate the parameters. The current study utilizes a one-dimensional wavelet to delete noise from the original SALS signal and estimate the variation trend of maximum intensity area of the scattered light. So, the system brought the qualitative analysis of the structural information of transparent film success

Formulation of Equations of Motion for a Simply Supported Bridge under a Moving Railway Freight Vehicle

Based on energy approach, the equations of motion in matrix form for the railway freight vehicle-bridge interaction system are derived, in which the dynamic contact forces between vehicle and bridge are considered as internal forces. The freight vehicle is modelled as a multi-rigid-body system, which comprises one car body, two bogie frames and four wheelsets. The bogie frame is linked with the car body through spring-dashpot suspension systems, and the bogie frame is rigidly linked with wheelsets. The bridge deck, together with railway track resting on bridge, is modelled as a simply supported Bernoulli-Euler beam and its deflection is described by superimposing modes. The direct time integration method is applied to obtain the dynamic response of the vehicle-bridge interaction system at each time step. A computer program has been developed for analyzing this system. The correctness of the proposed procedure is confirmed by one numerical example. The effect of different beam mode numbers and various surface irregularities of beam on the dynamic responses of the vehicle-bridge interaction system are investigated

Accretion Disk for regular black holes with sub-Planckian curvature

We investigate the accretion disk for a sort of regular black holes which are characterized by sub-Planckian curvature and Minkowskian core. We derive null geodesics outside the horizon of such regular black holes and analyze the feature of the light rays from the accretion disk which can be classified into direct emission, lensed rings, and photon rings. We find that the observed brightness under different emission models is mainly determined by direct emission, while the contribution from the flux of the lensed and photon rings is limited. By comparing with Bardeen black hole with a dS core, it is found that the black hole with a Minkowskian core exhibits distinct astronomical optical features when surrounded by accretion disk, which potentially provides a way to distinguish these two sorts of black holes by astronomical observation.Comment: 26 pages,9 figure

Problem Frame Analysis of Weapon System of Systems Requirement

AbstractThe requirement of weapon system of systems(WSoS) plays a very important role in the development of WSoS,which is the basis of the design of WSoS and runs through the research of WSoS. Based on the requirement engineering method of problem frame, the problem frame of WSoS requirement(WSoSR) is built which is consisted of requirement, mission domain, task domain, operation domain and system of systems(SoS) domain. The phenomena between the domains is defined and the constraint set is given. The model of the WSoSR problem transformation is put forward including the transformation process and the transformation content. An example of combined firing employment to the enemy ship fleet is shown in the end

Cicatricial Alopecia

Cicatricial alopecia represents a group of disorders sharing a final pathway of destruction followed by replacement with fibrous tissue of the hair follicle unit. Cicatricial alopecia is classified into two categories, namely primary cicatricial alopecia, in which the hair follicle is the sole target of a progressive inflammatory process in a group of diverse skin or systemic diseases, and secondary cicatricial alopecia, referring to the hair follicle destruction as a result of a nonspecific disruption of the dermis. Permanent hair loss may also occur in the late phases of some nonscarring alopecias that are called “biphasic alopecias.” Based on the pathological characteristics, the lesions of primary cicatricial alopecia are divided into lymphocyte-predominant subgroup, neutrophil-predominant subgroup, or mixed subgroup. In principle, the primary goal of the treatment aims to attenuate the progression of the inflammatory and the scarring processes at the earliest phase of the disease. In clinical practice, the lymphocyte-predominant lesions are treated with immunosuppressive agents, whereas the neutrophil-predominant lesions are treated with antimicrobials or dapsone. As the efficacy of medication treatment against the cicatricial alopecia varies significantly, autologous hair transplantation is recommended to patients who have a relatively stable primary or a secondary cicatricial alopecia

Endoscopic video defogging using luminance blending.

Endoscopic video sequences provide surgeons with direct surgical field or visualisation on anatomical targets in the patient during robotic surgery. Unfortunately, these video images are unavoidably hazy or foggy to prevent surgeons from clear surgical vision due to typical surgical operations such as ablation and cauterisation during surgery. This Letter aims at removing fog or smoke on endoscopic video sequences to enhance and maintain a direct and clear visualisation of the operating field during robotic surgery. The authors propose a new luminance blending framework that integrates contrast enhancement with visibility restoration for foggy endoscopic video processing. The proposed method was validated on clinical endoscopic videos that were collected from robotic surgery. The experimental results demonstrate that their method provides a promising means to effectively remove fog or smoke on endoscopic video images. In particular, the visual quality of defogged endoscopic images was improved from 0.5088 to 0.6475

Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens

<p>Abstract</p> <p>Background</p> <p>The aim of this study is to screen single nucleotide polymorphisms (SNP) of chicken <it>Calpain3 </it>(<it>CAPN3</it>) gene and to analyze the potential association between <it>CAPN3 </it>gene polymorphisms and carcass traits in chickens. We screened <it>CAPN3 </it>single nucleotide polymorphisms (SNP) in 307 meat-type quality chicken from 5 commercial pure lines (S01, S02, S03, S05, and D99) and 4 native breeds from Guangdong Province (Huiyang Huxu chicken and Qingyuan Ma chicken) and Sichuan Province (Caoke chicken and Shandi Black-bone chicken), China.</p> <p>Results</p> <p>Two SNPs (11818T>A and 12814T>G) were detected by single strand conformation polymorphism (SSCP) method and were verified by DNA sequencing. Association analysis showed that the 12814T>G genotypes were significantly associated with body weight (BW), carcass weight (CW), breast muscle weight (BMW), and leg muscle weight (LMW). Haplotypes constructed on the two SNPs (H1, TG; H2, TT; H3, AG; and H4, AT) were associated with BW, CW (<it>P </it>< 0.05), eviscerated percentage (EP), semi-eviscerated percentage (SEP), breast muscle percentage (BMP), and leg muscle percentage (LMP) (<it>P </it>< 0.01). Diplotype H1H2 was dominant for BW, CW, and LMP, and H2H2 was dominant for EP, SEP, and BMP.</p> <p>Conclusion</p> <p>We speculated that the <it>CAPN3 </it>gene was a major gene affecting chicken muscle growth and carcass traits or it was linked with the major gene(s). Diplotypes H1H2 and H2H2 might be advantageous for carcass traits.</p