HEMATOLOGICAL CHANGES IN PRISONERS WITH HIGHER BLOOD LEAD LEVELS COMPARED WITH GENERAL POPULATION

Lead (Pb) is one of the major environmental health hazards. From a biological point of view, lead is considered as anon-essential trace element and has no any biological function. The aims of the present study were to study blood lead levels among prisoners in the Northern of Jordan. Two prisons in the northern of Jordan were visited. Blood samples were collected and evaluated for hematological parameters and blood lead level. The study included 73 participants (46 prisoners and 27 participants as control). Study findings revealed low exposure of lead among study participants. The mean blood lead level among prisoners was 0.924 μg/dl, and 0.57μg/dl among control group. Hematological parameters under study were less in prisoners compared control group. Study findings revealed significant relationships between blood lead level and hematological parameters among prisoners. Taken together, the present study evaluated the effects of lead exposure on prisoners through studying these effects on some hematological parameters. The findings of the present study indicated that even prisoners had more blood lead levels compared with control group; the exposure variations were not statistically significant, but able to induce changes on studied hematological parameters

MOLECULAR MECHANISMS ASSOCIATED WITH ACUTE MYELOID LEUKEMIA: REVIEW ARTICLE

The present review article purposes to introduce the molecular mechanisms underlying acute myeloid leukemia (AML). An overview of AML was introduced including its classification, therapeutic options and the roles of mutations in p53 and WT1 genes. The possibility of molecular targeting therapies was also discussed. The efforts of many researchers concerning AML were taken into consideration during this review. We also pointed to the various roles of WT1 gene as suppressor or oncogene. The important relationship between p53 gene and WT1 gene was highlighted so that when WT1 gene stabilizes p53, the pathological picture concerning p53 if being mutated or not should be reconsidered again