How does digitalization alter the paradox of supply base concentration? The effects of digitalization intensity and breadth

Purpose – The highly uncertain and turbulent environments nowadays intensify the paradoxical effects of supply base concentration (SBC) on improving cost efficiency while increasing idiosyncratic risk (IR). Digitalization is regarded as a remedy for this paradox, yet digitization’s potentially curative effect has not been empirically tested. Leveraging the lenses of paradox theory and information processing theory (IPT), this study explores how two distinct dimensions of digitalization, i.e. digitalization intensity (DI) and digitalization breadth (DB), reconcile the paradoxical effects of SBC. Design/methodology/approach – Using a panel dataset of 1,238 Chinese manufacturing firms in the period of 2012–2020, this study utilizes fixed-effects regression models to test the proposed hypotheses. Findings – The authors discover that SBC enhances a firm’s cost efficiency but induces greater IR. More importantly, there is evidence that DI restrains the amplifying effect of SBC on IR. However, DB weakens the enhancing effect of SBC on cost efficiency and aggravates the SBC’s exacerbating effect on IR. Originality/value – This study advances the understanding of the paradoxical effects of SBC on cost efficiency and IR from a paradox theory perspective. More importantly, to the best of the authors’ knowledge, the authors’ study is the first to untangle the differential roles of DI and DB in reconciling the paradox of SBC. This study also provides practitioners with nuanced insights into how the practitioners should use appropriate tactics to deploy digital technologies effectively

Towards the demonstration of photon-photon collision with compact lasers

We report a proposal to observe the two-photon Breit-Wheeler process in plasma driven by compact lasers. A high charge electron bunch can be generated from laser plasma wakefield acceleration when a tightly focused laser pulse transports in a sub-critical density plasma. The electron bunch scatters with the laser pulse coming from the opposite direction and results the emitting of high brilliance X-ray pulses. In a three-dimensional particle-in-cell simulation with a laser pulse of $\sim$10 J, one could produce a X-ray pulse with photon number higher than $3\times10^{11}$ and brilliance above $1.6\times 10^{23}$ photons/s/mm$^2$/mrad$^2$/0.1$\%$BW at 1 MeV. The X-ray pulses collide in the plasma and create more than $1.1\times 10^5$ electron-positron pairs per shot. It is also found that the positrons can be accelerated transversely by a transverse electric field generated in the plasma, which enables the safe detection in the direction away from the laser pulses. This proposal which has solved key challenges in laser driven photon-photon collision could demonstrate the two-photon Breit-Wheeler process on a much more compact device in a single shot

Multi-Receiver Quantum Dense Coding with Non-Symmetric Quantum Channel

A two-receiver quantum dense coding scheme and an $N$-receiver quantum dense coding scheme, in the case of non-symmetric Hilbert spaces of the particles of the quantum channel, are investigated in this paper. A sender can send his messages to many receivers simultaneously. The scheme can be applied to quantum secret sharing and controlled quantum dense coding.Comment: To appear in Journal of the Korean Physical Societ

EGFR-mutated squamous cell lung cancer and its association with outcomes

Background: The therapeutic efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced EGFR-mutant lung squamous cell carcinoma (SCC) patients remains uncertain. Furthermore, the factors underlying the responsiveness have not been fully investigated. We therefore investigated the link between genomic profiles and EGFR-TKI efficacy. Material and Methods: We consecutively enrolled stage IV, EGFR-mutant, and EGFR-TKI-treated patients with SCC. Patients with EGFR wild-type lung SCC and EGFR-mutant lung adenocarcinoma were consecutively enrolled as controls, and next-generation sequencing (NGS) was performed. Results: In total, 28 EGFR-mutant lung SCC, 41 EGFR-mutant lung adenocarcinoma, and 40 EGFR wild-type lung SCC patients were included. Among the patients with EGFR mutations, shorter progression-free survival (PFS) was observed in SCC compared to adenocarcinoma (4.6 vs. 11.0 months, P<0.001). Comparison of the genomic profiles revealed that EGFR-mutant SCC patients had similar mutation characteristics to EGFR-mutant adenocarcinoma patients, but differed from those with EGFR wild-type SCC. Further exploration of EGFR-mutant SCC revealed that mutations in CREBBP (P = 0.005), ZNF217 (P = 0.016), and the Wnt (P = 0.027) pathway were negatively associated with PFS. Mutations in GRM8 (P = 0.025) were associated with improved PFS. Conclusions: EGFR-mutant lung SCC has a worse prognosis than EGFR-mutant adenocarcinoma. Mutations in other genes, such as CREBBP, ZNF217, GRM8, or Wnt that had implications on PFS raise the possibility of understanding mechanisms of resistance to EGFR-TKI in lung SCC, which will aid identification of potential beneficial subgroups of patients with EGFR-mutant SCCs receiving EGFR-TKIs