4 research outputs found
Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
- Author
- Abbadessa V.
- Abeli C.
- Abrescia N.
- Alberici F.
- Alessandrini A.
- Alexander C.
- Allen D.
- Anderson J.
- Angarano G.
- Antinori A.
- Antinori A.
- Antonucci G.
- Antunes F.
- Arici C.
- Arici C.
- Arlotti M.
- Ashton L.
- Ashton L.
- Austin D.
- Babiker A.
- Babiker A.
- Bachmann S.
- Back N. K. T.
- Baker D.
- Bal J.
- Baldelli F.
- Ballardini G.
- Balu R.
- Banhegyi D.
- Barton S.
- Basilico C.
- Battegay M.
- Becker S.
- Bedini A.
- Bedini A.
- Beijnen J. H.
- Beniowski M.
- Benne D.
- Beral V.
- Bernasconi E.
- Bertelli D.
- Bickel M.
- Blaxhult A.
- Block M.
- Blok W. L.
- Boel E.
- Bonner S.
- Bonten M. J. M.
- Borghi V.
- Borleffs J. C. C.
- Boron Kaczmarska A.
- Bos J. C.
- Bottari G.
- Boucher C. A. B.
- Boufassa F.
- Bradford D.
- Braitstein P.
- Braun J.
- Bravenboer B.
- Brettle R.
- Brettle R.
- Brinkman K.
- Bronsveld W.
- Brown K.
- Bruggeman C. A. M. V. A.
- Bruno R.
- Bruun J.
- Bruun J. N.
- Bucher H.
- Buiting A. G. M.
- Burger D. M.
- Burke M.
- BĂĽrgisser P.
- Cadeo G. P.
- Cadeo G. P.
- Caggese L.
- Cain A.
- Capobianchi M. R.
- Caramello P.
- Cargnel A.
- Carlebach A.
- Carnevale G.
- Carnevale G.
- Carosi G.
- Carosi G.
- Carr A.
- Casari S.
- Castagna A.
- Castelli Francesco
- Cattacin S.
- Cayla J.
- Chaloner C.
- Chan K.
- Chaplinskas S.
- Chentsova N.
- Chiesi A.
- Chigiotti S.
- Chimienti A.
- Chiodo F.
- Chirianni A.
- Chirianni A.
- Chuah J.
- ChĂŞne G.
- Ciardi Maria Rosa
- Cioppi A.
- Claas H. C. J.
- Claessen F. A. P.
- Clemons J.
- Clotet B.
- Clotet B.
- Clumeck N.
- Colangeli V.
- Colebunders R.
- Colomba A.
- Conejero J.
- Cooper D.
- Cooper D.
- Cooper D.
- Costantini A.
- Cote H.
- Couldwell D.
- Coutinho R.
- Coutinho R.
- Crommentuyn K. M. L.
- Cuijpers T.
- d'Arminio Monforte Antonella
- D'Elia S.
- D'Offizi G.
- Dabis F.
- Danner S. A.
- Darbyshire J.
- Darbyshire J.
- Darbyshire J.
- Dauer B.
- Day N. E.
- Daye J.
- De Angelis D.
- De Lalla F.
- De Longis P.
- De Luca A.
- de Maat M. M. R.
- De Marco M.
- de Marie S.
- De Sa M.
- De Stefano C.
- De Wit S.
- de Wolf F.
- Del Amo J.
- Del Amo J.
- Del Forno L.
- del Romero J.
- Dianzani F.
- Diaz B.
- Dickson B.
- Dieterich D.
- Dietrich M.
- Doerr H. W.
- Duiculescu D.
- Duran A.
- Egger M.
- Egger M.
- Ellis D.
- Erb P.
- Eskild A.
- Esposito R.
- Esposito R.
- Esposito R.
- Eu B.
- Fairley K.
- Fankhauser W.
- Ferrara S.
- Ferrari C.
- Ferraro T.
- Fibbia G.
- Fierz W.
- Filandras A.
- Filice G.
- Finlayson R.
- Fiorini C.
- Fischer M.
- Fisher M.
- Fleenor R.
- Flepp M.
- Fontana A.
- Franci P.
- Francioli P.
- Francioli P.
- Francioli P.
- Franck P. F. H.
- French M.
- Frissen P. H. J.
- Furrer H.
- Furrer H. J.
- Fusco Gregory
- Fusco J.
- Gabbuti A.
- Galama J. M. D.
- Galli A.
- Galloni D.
- Garcia de Olalla P.
- GarcĂa Benayas T.
- Gargalianos P.
- Gasiorowski J.
- Gataric N.
- Gatell J. M.
- Geerlings S. E.
- Gennero L.
- Gerstoft J.
- Ghinelli F.
- Ghinelli F.
- Giacometti A.
- Gilbert L.
- Gill J.
- Gill J.
- Gill N.
- Gill N.
- Girardi E.
- Godfried M. H.
- Goebel F. D.
- González Lahoz J.
- Goossens V. J.
- Gorgievski M.
- Gorton C.
- Gras L.
- Grima P.
- Grisorio B.
- Gritti F. M.
- Groeneveld P. H. P.
- Grossi P. A.
- Guerra L.
- Gumley H.
- Gute P.
- Gyssens I. C.
- GĂĽnthard H.
- Haberl A.
- Hamouda O.
- Hansen A. B. E.
- Harrigan P. R.
- Harris M.
- Hassoun J.
- Hatzakis A.
- Helm E. B.
- Hemmer R.
- Hendriks R.
- Hernández Aguado I.
- Hillebrand Haverkort M. E.
- Hirschel B.
- Hirschel B.
- Hoepelman I. M.
- Hogg Robert
- Horban A.
- Hoy J.
- Huffam S.
- Hugen P. W. H.
- Huitema A. D. R.
- Ippolito G.
- Ising T.
- Izzo C.
- Jansen C. L.
- Jansz A. F.
- Jaspers C. A. J. J.
- Jennings B.
- Jeurissen F. J. F.
- John Gill M.
- Johnson A. M.
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- Jou A.
- Jurriaans S.
- Justice Amy
- Juttmann J. R.
- Kabeya K.
- Kaiser L.
- Kaldor J.
- Kappelhoff B.
- Karafoulidou A.
- Karlsson A.
- Katlama C.
- Katsarou O.
- Katzenstein T.
- Kauffmann R. H.
- Keeffe N.
- Kidd J.
- Kind C.
- Kirk O.
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- Klauke S.
- Klimkait T.
- Knibbs P.
- Knysz B.
- Koger E. L. W.
- Koopmans P. P.
- Korn S.
- Kosmidis J.
- Kroes A. C. M.
- Kroon F. P.
- La Gala A.
- Ladisa N.
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- Lampe A. S.
- Lampe Fiona
- Lange J. M. A.
- Lauper U.
- Law Matthew
- Lawson Ayayi S.
- Lazzarin A.
- Lazzarin A.
- Ledergerber Bruno
- Lee C.
- Lee C.
- Leemhuis M. P.
- Leoncini F.
- Lepri Cozzi A.
- Liang M. T.
- Lichtner Miriam
- Lipman M.
- Lister G.
- Lo Caputo S.
- Locher L.
- Losso M.
- Loveday C.
- Lowe S. H.
- Lundgren J.
- Lundgren Jens D.
- Lutz T.
- Maayan S.
- Machala L.
- Maeland A.
- Maggiolo F.
- Magnani G.
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- Mairuhu A. T. A.
- Mallal S.
- Maltez F.
- Manconi P. E.
- Mancuso S.
- Manegold C.
- Mannazzu M.
- Mansinho K.
- Manzillo E.
- Martin Carbonero L.
- Martinelli C.
- Maserati R.
- Maserati R.
- Maxwel D.
- Mazzotta F.
- Mazzotta F.
- Mazzotta F.
- Mccormack C.
- Mcfarlane R.
- Mcgovern G.
- Mcnair R.
- Medland N.
- Meenhorst P. L.
- Mena M.
- Menichetti F.
- Mercey D.
- Merli S.
- Meyer L.
- Meyer L.
- Miesen W. M. A. J.
- Migliorino G.
- Migliorino M.
- Mijch A.
- Miller J.
- Miller V.
- Minardi C.
- Minoli L.
- Minoli L.
- MirĂł J. M.
- Mocroft A.
- Mocroft A.
- Moioli C.
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- Montaner J.
- Montesarchio E.
- Montesarchio V.
- Montroni M.
- Moore R.
- Moretti F.
- Morgan S.
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- Most B.
- Mudrikova T.
- Muga R.
- Mulcahy F.
- Mulder J. W.
- Mulhall B.
- Mura M. S.
- Murphy M.
- Mussini Cristina
- Mutimer K.
- Mösch M.
- MĂĽller A.
- Nappa S.
- Narciso P.
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- Nielsen J.
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- Noto P.
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- O'Connor C.
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- Ormaasen V.
- Orth D.
- Ortolani P.
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- Osterhaus A. D. M. E.
- Paccaud F.
- Pagano G.
- Pan A.
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- Paraninfo G.
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- Pastore G.
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- Pedersen C.
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- Pehrson P.
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- Perdios J.
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- Sarah Walker A.
- Savage J.
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- van der Ende M. E.
- van der Meer J. T. M.
- van der Poll T.
- van der Valk M.
- van der Ven A. J. A. M.
- van Eeden A.
- van Gorp E. C. M.
- van Houte D. P. F.
- van Leusen R.
- van Lunzen J.
- van Sighem A. I.
- van Valkengoed I.
- van Vonderen M. G. A.
- van Zanten A. P.
- van Zeijl J. H.
- Vangi D.
- Vanhems P.
- Vanhems P.
- Vanhems P.
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- Veenstra J.
- Veldkamp A.
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- Verbon A.
- Vernazza P.
- Vetter N.
- Viard J. P.
- Viganò P.
- Vigevani G. M.
- Viksna L.
- Vincenti A.
- Vizzard J.
- von Blomberg B. M. E.
- Vriesendorp R.
- Vullo Vincenzo
- Vullo Vincenzo
- Walker A.
- Walker S.
- Watson K.
- Weber J.
- Weber Rainer
- Weigel H. M.
- Wiercinska Drapalo A.
- Wilson C.
- Wit F. W. M. N.
- Wit Ferdinand
- Wood E.
- Wood H.
- Yerly S.
- Yip B.
- Youle M.
- Youle M.
- Yust I.
- Zaaijer H.
- Zaccarelli M.
- Zaccarelli M.
- Zamora L.
- Zauli T.
- Zilmer K.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
Background Treatment strategies for patients in whom HIV replication is not suppressed after exposure to several drug classes remain unclear. We aimed to assess the inter-relations between viral load, CD4-cell count, and clinical outcome in patients who had experienced three-class virological failure. Methods We undertook collaborative joint analysis of 13 HIV cohorts from Europe, North America, and Australia, involving patients who had had three-class virological failure (viral load >1000 copies per mL for >4 months). Regression analyses were used to quantify the associations between CD4-cell-count slope, HIV-1 RNA concentration, treatment information, and demographic characteristics. Predictors of death were analysed by Cox's proportional-hazards models. Findings 2488 patients were included. 2118 (85%) had started antiretroviral therapy with single or dual therapy. During 5015 person-years of follow-up, 276 patients died (mortality rate 5.5 per 100 person-years; 3-year mortality risk 15.3% (95% Cl 13.5-17.3). Risk of death was strongly influenced by the latest CD4-cell count with a relative hazard of 15.8 (95% CI 9.28-27.0) for counts below 50 cells per muL versus above 200 cells per muL. The latest viral load did not independently predict death. For any given viral load, patients on treatment had more favourable CD4-cell-count slopes than those off treatment. For patients on treatment and with stable viral load, CD4-cell counts tended to be increasing at times when the current viral load was below 10 000 copies per mL or 1.5 log(10) copies per mL below off-treatment values. Interpretation In patients for whom viral-load suppression to below the level of detection is not possible, achievement and maintenance of a CD4-cell count above 200 per muL becomes the primary aim. Treatment regimens that maintain the viral load below 10 000 copies per mL or at least provide 1.5 log(10) copies per mL suppression below the off-treatment value do not seem to be associated with appreciable CD4-cell-count decline
Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
- Author
- Abbadessa V
- Abeli C
- Abrescia N
- Aguado IH
- Alberici F
- Alessandrini A
- Alexander C
- Allen D
- Anderson J
- Angarano G
- Antinori A
- Antinori A
- Antonucci G
- Antunes F
- Arici C
- Arici C
- Arici C
- Arlotti M
- Ashton L
- Ashton L
- Austin D
- Babiker A
- Babiker A
- Bachmann S
- Back NKT
- Baker D
- Bal J
- Baldelli F
- Ballardini G
- Balu R
- Banhegyi D
- Barton S
- Basilico C
- Battegay M
- Becker S
- Bedini A
- Bedini A
- Beijnen JH
- Beniowski M
- Benne D
- Beral V
- Bernasconi E
- Bertelli D
- Bickel M
- Blaxhult A
- Block M
- Blok WL
- Boel E
- Bonner S
- Bonten MJM
- Borghi V
- Borleffs JCC
- Boron-Kaczmarska A
- Bos JC
- Bottari G
- Boucher CAB
- Boufassa F
- Bradford D
- Braitstein P
- Braun J
- Bravenboer B
- Brettle R
- Brettle R
- Brinkman K
- Bronsveld W
- Brown K
- Bruggeman CAMVA
- Bruno R
- Bruun J
- Bruun JN
- Bucher H
- Buiting AGM
- Burger DM
- Burgisser P
- Burke M
- Cadeo GP
- Cadeo GP
- Caggese L
- Cain A
- Capobianchi MR
- Caramello P
- Cargnel A
- Carlebach A
- Carnevale G
- Carnevale G
- Carosi G
- Carosi G
- Carr A
- Casari S
- Castagna A
- Castelli F
- Castelli F
- Castelli F
- Castelli F
- Cattacin S
- Cayla J
- Chaloner C
- Chan K
- Chaplinskas S
- Chene G
- Chentsova N
- Chiesi A
- Chigiotti S
- Chimienti A
- Chiodo F
- Chirianni A
- Chirianni A
- Chuah J
- Ciardi M
- Cioppi A
- Claas HCJ
- Claessen FAP
- Clemons J
- Clotet B
- Clotet B
- Clumeck N
- Colangeli V
- Colebunders R
- Colomba A
- Conejero J
- Cooper D
- Cooper D
- Cooper D
- Cooper D
- Costantini A
- Cote H
- Couldwell D
- Coutinho R
- Coutinho R
- Crommentuyn KML
- Cuijpers T
- D'Elia S
- D'Offizi G
- Dabis F
- Danner SA
- Darbyshire J
- Darbyshire J
- Darbyshire J
- Dauer B
- Day NE
- Daye J
- De Angelis D
- De Lalla F
- De Longis P
- De Luca A
- de Maat MMR
- De Marco M
- de Marie S
- de Olalla PG
- De Sa M
- De Stefano C
- De Wit S
- de Wolf F
- Del Amo J
- Del Amo J
- Del Forno L
- del Romero J
- Dianzani F
- Diaz B
- Dickson B
- Dieterich D
- Dietrich M
- Doerr HW
- Duiculescu D
- Duran A
- Egger M
- Egger M
- Ellis D
- Erb P
- Eskild A
- Esposito R
- Esposito R
- Esposito R
- Eu B
- Fairley K
- Fankhauser W
- Ferrara S
- Ferrari C
- Ferraro T
- Fibbia G
- Fierz W
- Filandras A
- Filice G
- Finlayson R
- Fiorini C
- Fischer M
- Fisher M
- Fleenor R
- Flepp M
- Fontana A
- Franci P
- Francioli P
- Francioli P
- Francioli P
- Franck PFH
- French M
- Frissen PHJ
- Furrer H
- Furrer HJ
- Fusco G
- Fusco G
- Fusco GP
- Fusco J
- Gabbuti A
- Galama JMD
- Galli A
- Galloni D
- Garcia-Benayas T
- Gargalianos P
- Gasiorowski J
- Gataric N
- Gatell JM
- Geerlings SE
- Gennero L
- Gerstoft J
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- Giacometti A
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- Girardi E
- Godfried MH
- Goebel FD
- Gonzalez-Lahoz J
- Goossens VJ
- Gorgievski M
- Gorton C
- Gras L
- Grima P
- Grisorio B
- Gritti FM
- Groenveld PHP
- Grossi PA
- Guerra L
- Gumley H
- Gute P
- Gyssens IC
- Haberl A
- Hamouda O
- Hansen ABE
- Harrigan PR
- Harris M
- Hassoun J
- Hatzakis A
- Helm EB
- Hemmer R
- Hendriks R
- Hillebrand-Haverkort ME
- Hirschel B
- Hirschel B
- Hoepelman IM
- Hogg R
- Hogg R
- Hogg R
- Horban A
- Hoy J
- Huffam S
- Hugen PWH
- Huitema ADR
- Ippolito G
- Ising T
- Izzo C
- Jansen CL
- Jansz AF
- Jaspers CAJJ
- Jennings B
- Jeurissen FJF
- Johnson AM
- Johnson AM
- Johnson M
- Johnson MA
- Jou A
- Jurriaans S
- Justice A
- Justice A
- Juttmann JR
- Kabeya K
- Kaiser L
- Kaldor J
- Kaldor J
- Kappelhoff B
- Karafoulidou A
- Karlsson A
- Katlama C
- Katsarou O
- Katzenstein T
- Kauffmann RH
- Keeffe N
- Kidd J
- Kind C
- Kirk O
- Kirk O
- Klauke S
- Klimkait T
- Knibbs P
- Knysz B
- Koger ELW
- Koopmans PP
- Korn S
- Kosmidis J
- Kroes ACM
- Kroon FP
- La Gala A
- Ladisa N
- Ladisa N
- Lampe AS
- Lampe F
- Lampe F
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- Lange JMA
- Lauper U
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- Lazzarin A
- Lazzarin A
- Ledergerber B
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- Lee C
- Lee C
- Leemhuis MP
- Leoncini F
- Lepri AC
- Liang MT
- Lichtner M
- Lipman M
- Lister G
- Lo Caputo S
- Locher L
- Losso M
- Loveday C
- Lowe SH
- Lundgren J
- Lundgren JD
- Lundgren JD
- Lutz T
- Maayan S
- Machala L
- Maeland A
- Maggiolo F
- Magnani G
- Magon H
- Mairuhu ATA
- Mallal S
- Maltez F
- Manconi PE
- Mancuso S
- Manegold C
- Mannazzu M
- Mansinho K
- Manzillo E
- Martin-Carbonero L
- Martinelli C
- Maserati R
- Maserati R
- Maxwel D
- Mazzotta F
- Mazzotta F
- Mazzotta F
- McCormack C
- McFarlane R
- McGovern G
- McNair R
- Medland N
- Meenhorst PL
- Mena M
- Menichetti F
- Mercey D
- Merli S
- Meyer L
- Meyer L
- Miesen WMAJ
- Migliorino G
- Migliorino M
- Mijch A
- Miller J
- Miller V
- Minardi C
- Minoli L
- Minoli L
- Miro JM
- Mocroft A
- Mocroft A
- Moioli C
- Mokras M
- Monforte AD
- Monforte AD
- Monforte AD
- Monforte AD
- Montaner J
- Montesarchio E
- Montesarchio V
- Montroni M
- Moore R
- Moretti F
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- Mosch M
- Most B
- Mudrikova T
- Muga R
- Mulcahy F
- Mulder JW
- Mulhall B
- Muller A
- Mura MS
- Murphy M
- Mussini C
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- Novati R
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- O'Connor C
- O'Shaughnessy M
- Olsen CH
- Opravil M
- Orani A
- Orani A
- Ormaasen V
- Orth D
- Ortolani P
- Ortona L
- Osterhaus ADME
- Paccaud F
- Pagano G
- Pan A
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- Pantaleo G
- Paraninfo G
- Pasquinucci S
- Pastecchia C
- Pastore G
- Pastore G
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- Pauw W
- Pedersen C
- Pedersen C
- Pehrson P
- Pell C
- Perdios J
- Perenboom RM
- Perez-Hoyos S
- Perini P
- Perini P
- Perrin L
- Perulli ML
- Petoumenos K
- Petrelli E
- Petrosillo N
- Pezzotti P
- Pezzotti P
- Phillips A
- Phillips AN
- Phillips AN
- Phillips AN
- Phillips AN
- Piano P
- Piazza M
- Pierce A
- Piersantelli N
- Piffaretti JC
- Piscopo R
- Pizzigallo E
- Pogany K
- Poggio A
- Poggio A
- Pole M
- Poll B
- Pollack S
- Poort YAGM
- Porter K
- Porter K
- Pozzi M
- Pradier C
- Prestileo T
- Prins JM
- Prins M
- Pristera R
- Prokopowicz D
- Pusterla L
- Pynka M
- Pzzaferri P
- Quan D
- Quiros-Roldan E
- Raffanti S
- Raise E
- Ransom D
- Rauka M
- Read R
- Ree H
- Reiss P
- Reiss P
- Reiss P
- Reiss P
- Resta F
- Rezza G
- Rezza G
- Rezza G
- Ricci F
- Riccio G
- Richter C
- Rickenbach M
- Rickenbach M
- Rietra PJGM
- Rizzardini G
- Rizzardini G
- Rockstroh J
- Rooney P
- Roozendaal KJ
- Roth N
- Rozentale B
- Rozsypal H
- Rudin C
- Ruggieri A
- Ruiz L
- Russell D
- Russell D
- Ruys TA
- Sabin C
- Sabin C
- Sabin C
- Sabin CA
- Saint-Marc T
- Salassa B
- Salzberger B
- Sambatakou H
- Sankatsing S
- Sannes M
- Santopadre P
- Santoro D
- Savage J
- Savelkoul P
- Scalise G
- Scalzini A
- Scarsella A
- Scasso A
- Scerbo A
- Schattenkerk JKME
- Schiffer V
- Schippers EF
- Schirm J
- Schneider MME
- Schouten I
- Schreij G
- Schupbach J
- Schurink CAM
- Schutten M
- Schuurman R
- Sciandra M
- Scullard G
- Sighinolfi L
- Sighinolfi L
- Sinicco A
- Skett J
- Skinhoj P
- Smiatacz T
- Smith D
- Smith D
- Smits PHM
- Soranzo ML
- Soriano V
- Soscia F
- Sowden D
- Speck R
- Sprenger HG
- Stanekova D
- Staszewski S
- Staszewski S
- Staszewski S
- Staszewski S
- Staub T
- Stellbrink HJ
- Stephan C
- Sthoeger Z
- Storm H
- Strecker S
- Streinu-Cercel A
- Sturmer M
- Suter F
- Suter F
- Swaans CAM
- Swanink C
- Taccooni L
- Tarr P
- Taylor S
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- Telgt M
- ten Kate RW
- ten Napel CHH
- ten Veen JH
- Thiebaut R
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- Tordato F
- Torti C
- Tositti G
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- Touloumi G
- Trkola A
- Trocha H
- Tundo P
- Tural C
- Tyrer F
- Uccelli MC
- Ursitti MA
- Van Agtmael MA
- van Asten L
- van Benthem B
- van Dam PS
- van de Geest S
- van der Berg J
- van der Ende ME
- van der Meer JTM
- van der Poll T
- van der Valk M
- van der Ven AJAM
- van Eeden A
- van Gorp ECM
- van Houte DPF
- van Leusen R
- van Lunzen J
- van Sighem AI
- van Valkengoed I
- van Vonderen MGA
- van Zanten AP
- van Zeijl JH
- Vangi D
- Vanhems P
- Vanhems P
- Vanhems P
- Veenendaal D
- Veenstra J
- Veldkamp A
- Vella S
- Verbon A
- Vernazza P
- Vetter N
- Viard JP
- Vigano P
- Vigevani GM
- Viksna L
- Vincenti A
- Vizzard J
- von Blomberg BME
- Vriesendorp R
- Vullo V
- Vullo V
- Walker A
- Walker AS
- Walker AS
- Walker S
- Watson K
- Weber J
- Weber R
- Weber R
- Weber R
- Weigel HM
- Wiercinska-Drapalo A
- Wilson C
- Wit F
- Wit FWMN
- Wood E
- Wood H
- Yerly S
- Yip B
- Youle M
- Youle M
- Yust I
- Zaaijer H
- Zaccarelli M
- Zaccarelli M
- Zamora L
- Zauli T
- Zilmer K
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
Background Treatment strategies for patients in whom HIV replication is not suppressed after exposure to several drug classes remain unclear. We aimed to assess the inter-relations between viral load, CD4-cell count, and clinical outcome in patients who had experienced three-class virological failure. Methods We undertook collaborative joint analysis of 13 HIV cohorts from Europe, North America, and Australia, involving patients who had had three-class virological failure (viral load >1000 copies per mL for >4 months). Regression analyses were used to quantify the associations between CD4-cell-count slope, HIV-1 RNA concentration, treatment information, and demographic characteristics. Predictors of death were analysed by Cox's proportional-hazards models. Findings 2488 patients were included. 2118 (85%) had started antiretroviral therapy with single or dual therapy. During 5015 person-years of follow-up, 276 patients died (mortality rate 5.5 per 100 person-years; 3-year mortality risk 15.3% (95% Cl 13.5-17.3). Risk of death was strongly influenced by the latest CD4-cell count with a relative hazard of 15.8 (95% CI 9.28-27.0) for counts below 50 cells per muL versus above 200 cells per muL. The latest viral load did not independently predict death. For any given viral load, patients on treatment had more favourable CD4-cell-count slopes than those off treatment. For patients on treatment and with stable viral load, CD4-cell counts tended to be increasing at times when the current viral load was below 10 000 copies per mL or 1.5 log(10) copies per mL below off-treatment values. Interpretation In patients for whom viral-load suppression to below the level of detection is not possible, achievement and maintenance of a CD4-cell count above 200 per muL becomes the primary aim. Treatment regimens that maintain the viral load below 10 000 copies per mL or at least provide 1.5 log(10) copies per mL suppression below the off-treatment value do not seem to be associated with appreciable CD4-cell-count decline
Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
- Author
- Abbadessa V
- Abeli C
- Abrescia N
- Aguado IH
- Alberici F
- Alessandrini A
- Alexander C
- Allen D
- Anderson J
- Angarano G
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- Antonucci G
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- Back NKT
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- Basilico C
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- Bernasconi E
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- Bickel M
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- Bonten MJM
- Borghi V
- Borleffs JCC
- Boron-Kaczmarska A
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- Bottari G
- Boucher CAB
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- Bravenboer B
- Brettle R
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- Bronsveld W
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- Bruggeman CAMVA
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- Capobianchi MR
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- Claessen FAP
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- Crommentuyn KML
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- Montesarchio E
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- Most B
- Mudrikova T
- Muga R
- Mulcahy F
- Mulder JW
- Mulhall B
- Muller A
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- Mussini C
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- Nappa S
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- O'Shaughnessy M
- Olsen CH
- Opravil M
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- Ormaasen V
- Orth D
- Ortolani P
- Ortona L
- Osterhaus ADME
- Paccaud F
- Pagano G
- Pan A
- Panos G
- Pantaleo G
- Paraninfo G
- Pasquinucci S
- Pastecchia C
- Pastore G
- Pastore G
- Patroni A
- Pauluzzi S
- Pauw W
- Pedersen C
- Pedersen C
- Pehrson P
- Pell C
- Perdios J
- Perenboom RM
- Perez-Hoyos S
- Perini P
- Perini P
- Perrin L
- Perulli ML
- Petoumenos K
- Petrelli E
- Petrosillo N
- Pezzotti P
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- Phillips A
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- Piazza M
- Pierce A
- Piersantelli N
- Piffaretti JC
- Piscopo R
- Pizzigallo E
- Pogany K
- Poggio A
- Poggio A
- Pole M
- Poll B
- Pollack S
- Poort YAGM
- Porter K
- Porter K
- Pozzi M
- Pradier C
- Prestileo T
- Prins JM
- Prins M
- Pristera R
- Prokopowicz D
- Pusterla L
- Pynka M
- Pzzaferri P
- Quan D
- Quiros-Roldan E
- Raffanti S
- Raise E
- Ransom D
- Rauka M
- Read R
- Ree H
- Reiss P
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- Rezza G
- Rezza G
- Rezza G
- Ricci F
- Riccio G
- Richter C
- Rickenbach M
- Rickenbach M
- Rietra PJGM
- Rizzardini G
- Rizzardini G
- Rockstroh J
- Rooney P
- Roozendaal KJ
- Roth N
- Rozentale B
- Rozsypal H
- Rudin C
- Ruggieri A
- Ruiz L
- Russell D
- Russell D
- Ruys TA
- Sabin C
- Sabin C
- Sabin C
- Sabin CA
- Saint-Marc T
- Salassa B
- Salzberger B
- Sambatakou H
- Sankatsing S
- Sannes M
- Santopadre P
- Santoro D
- Savage J
- Savelkoul P
- Scalise G
- Scalzini A
- Scarsella A
- Scasso A
- Scerbo A
- Schattenkerk JKME
- Schiffer V
- Schippers EF
- Schirm J
- Schneider MME
- Schouten I
- Schreij G
- Schupbach J
- Schurink CAM
- Schutten M
- Schuurman R
- Sciandra M
- Scullard G
- Sighinolfi L
- Sighinolfi L
- Sinicco A
- Skett J
- Skinhoj P
- Smiatacz T
- Smith D
- Smith D
- Smits PHM
- Soranzo ML
- Soriano V
- Soscia F
- Sowden D
- Speck R
- Sprenger HG
- Stanekova D
- Staszewski S
- Staszewski S
- Staszewski S
- Staszewski S
- Staub T
- Stellbrink HJ
- Stephan C
- Sthoeger Z
- Storm H
- Strecker S
- Streinu-Cercel A
- Sturmer M
- Suter F
- Suter F
- Swaans CAM
- Swanink C
- Taccooni L
- Tarr P
- Taylor S
- Telenti A
- Telgt M
- ten Kate RW
- ten Napel CHH
- ten Veen JH
- Thiebaut R
- Tinelli C
- Tirelli U
- Tomasoni L
- Tordato F
- Torti C
- Tositti G
- Toti M
- Touloumi G
- Trkola A
- Trocha H
- Tundo P
- Tural C
- Tyrer F
- Uccelli MC
- Ursitti MA
- Van Agtmael MA
- van Asten L
- van Benthem B
- van Dam PS
- van de Geest S
- van der Berg J
- van der Ende ME
- van der Meer JTM
- van der Poll T
- van der Valk M
- van der Ven AJAM
- van Eeden A
- van Gorp ECM
- van Houte DPF
- van Leusen R
- van Lunzen J
- van Sighem AI
- van Valkengoed I
- van Vonderen MGA
- van Zanten AP
- van Zeijl JH
- Vangi D
- Vanhems P
- Vanhems P
- Vanhems P
- Veenendaal D
- Veenstra J
- Veldkamp A
- Vella S
- Verbon A
- Vernazza P
- Vetter N
- Viard JP
- Vigano P
- Vigevani GM
- Viksna L
- Vincenti A
- Vizzard J
- von Blomberg BME
- Vriesendorp R
- Vullo V
- Vullo V
- Walker A
- Walker AS
- Walker AS
- Walker S
- Watson K
- Weber J
- Weber R
- Weber R
- Weber R
- Weigel HM
- Wiercinska-Drapalo A
- Wilson C
- Wit F
- Wit FWMN
- Wood E
- Wood H
- Yerly S
- Yip B
- Youle M
- Youle M
- Yust I
- Zaaijer H
- Zaccarelli M
- Zaccarelli M
- Zamora L
- Zauli T
- Zilmer K
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
- Author
- Castelli F
- d'Arminio Monforte A
- Fusco G
- Gill MJ
- Hogg R
- Justice A
- Lampe F
- Law M
- Ledergerber B
- Lundgren JD
- Mussini C
- Phillips AN
- Reiss P
- Rooney P.q, Taylor, S.q, Couldwell, D.r, Austin, D.s, Block, M.s, Clemons, J.s, Finlayson, R.s, Petoumenos, K.s, Quan, D.s, Smith, D.s, O'Connor, C.t, Gorton, C.t, Allen, D.u, Mulhall, B.u, Mutimer, K.v, Keeffe, N.v, Cooper, D.w, Carr, A.w, Miller, J.w, Pell, C.w, Ellis, D.x, Baker, D.y, Kidd, J.y, McFarlane, R.y, Liang, M.T.z, Brown, K.aa, Huffam, S.ab, Savage, J.ab, Morgan, S.ab, Knibbs, P.ab, Sowden, D.ac, Walker, A.ac, Orth, D.ad, Lister, G.ad, Chuah, J.ae, Fankhauser, W.ae, Dickson, B.ae, Bradford, D.af, Wilson, C.af, Ree, H.ag, Magon, H.ag, Anderson, J.ah, Moore, R.ah, Russell, D.ah, McGovern, G.ah, McNair, R.ah, Bal, J.ah, Fairley, K.ah, Roth, N.ai, Eu, B.ai, Strecker, S.ai, Russell, D.ai, Wood, H.ai, Mijch, A.aj, Hoy, J.aj, Pierce, A.aj, McCormack, C.aj, Watson, K.aj, Medland, N.ak, Daye, J.al, Mallal, S.am, French, M.am, Skett, J.am, Maxwel, D.am, Cain, A.am, Montroni, M.an, Scalise, G.an, Costantini, A.an, Giacometti, A.an, Tirelli, U.ao, Nasti, G.ao, Pastore, G.ap, Ladisa, N.ap, Perulli, M.L.ap, Pastore, G.ap, Ladisa, N.ap, Suter, F.aq, Arici, C.aq, Suter, F.aq, Maggiolo, F.aq, Chiodo, F.ar, Gritti, F.M.ar, Colangeli, V.ar, Fiorini, C.ar, Guerra, L.ar, Carosi, G.as, Cadeo, G.P.as, Minardi, C.as, Vangi, D.as, Carosi, G.as, Paraninfo, G.as, Casari, S.as, Pan, A.as, Patroni, A.as, Torti, C.as, Quiros-Roldan, E.as, Tomasoni, L.as, Moretti, F.as, Nasta, P.as, Uccelli, M.C.as, Cadeo, G.P.as, Bertelli, D.as, Rizzardini, G.at, Migliorino, G.at, Rizzardini, G.at, Migliorino, M.at, Abeli, C.at, Manconi, P.E.au, Piano, P.au, Ferraro, T.av, Scerbo, A.av, Pizzigallo, E.aw, Ricci, F.aw, Santoro, D.ax, Pusterla, L.ax, Carnevale, G.ay, Galloni, D.ay, Carnevale, G.ay, Viganò, P.az, Mena, M.az, Ghinelli, F.ba, Sighinolfi, L.ba, Ghinelli, F.ba, Sighinolfi, L.ba, Leoncini, F.bb, Mazzotta, F.bb, Pozzi, M.bb, Lo Caputo, S.bb, Angarano, G.bc, Grisorio, B.bc, Ferrara, S.bc, Grima, P.bd, Tundo, P.bd, Pagano, G.be, Piersantelli, N.be, Alessandrini, A.be, Piscopo, R.be, Toti, M.bf, Chigiotti, S.bf, Soscia, F.bg, Tacconi, L.bg, Orani, A.bh, Perini, P.bh, Orani, A.bh, Perini, P.bh, Nigro, M.bh, Scasso, A.bi, Vincenti, A.bi, Scalzini, A.bj, Fibbia, G.bj, Moroni, M.bk, Lazzarin, A.bk, Cargnel, A.bk, Vigevani, G.M.bk, Caggese, L.bk, Tordato, F.bk, Novati, R.bk, Galli, A.bk, Merli, S.bk, Pastecchia, C.bk, Moioli, C.bk, Esposito, R.bl, Abrescia, N.bm, Chirianni, A.bm, Izzo, C.bm, Piazza, M.bm, De Marco, M.bm, Montesarchio, V.bm, Manzillo, E.bm, Nappa, S.bm, Colomba, A.bn, Abbadessa, V.bn, Prestileo, T.bn, Mancuso, S.bn, Ferrari, C.bo, Pzzaferri, P.bo, Filice, G.bp, Minoli, L.bp, Bruno, R.bp, Maserati, R.bp, Minoli, L.bp, Maserati, R.bp, Novati, S.bp, Tinelli, C.bp, Pauluzzi, S.bq, Baldelli, F.bq, Petrelli, E.br, Cioppi, A.br, Alberici, F.bs, Ruggieri, A.bs, Menichetti, F.bt, Martinelli, C.bt, De Stefano, C.bu, La Gala, A.bu, Zauli, T.bv, Ballardini, G.bv, Magnani, G.bw, Ursitti, M.A.bw, Arlotti, M.bx, Ortolani, P.bx, Ortona, L.by, Dianzani, F.by, Ippolito, G.by, Antinori, A.bz, Antonucci, G.bz, D'Elia, S.bz, Narciso, P.bz, Petrosillo, N.bz, Vullo, V.bz, De Luca, A.bz, Del Forno, L.bz, Zaccarelli, M.bz, De Longis, P.bz, Ciardi, M.bz, D'Offizi, G.bz, Noto, P.bz, Lichtner, M.bz, Capobianchi, M.R.bz, Girardi, E.bz, Pezzotti, P.bz, Rezza, G.bz, Mura, M.S.ca, Mannazzu, M.ca, Caramello, P.cb, Sinicco, A.cb, Soranzo, M.L.cb, Gennero, L.cb, Sciandra, M.cb, Salassa, B.cb, Grossi, P.A.cc, Basilico, C.cc, Poggio, A.cd, Bottari, G.cd, Poggio, A.cd, Raise, E.ce, Pasquinucci, S.ce, De Lalla, F.cf, Tositti, G.cf, Resta, F.cg, Chimienti, A.cg, Lepri Cozzi, A.ch, Bachmann, S.fb, Battegay, M.fb, Bernasconi, E.fb, Bucher, H.fb, BĂĽrgisser, P.fb, Cattacin, S.fb, Egger, M.fb, Erb, P.fb, Fierz, W.fb, Fischer, M.fb, Flepp, M.fb, Fontana, A.fb, Francioli, P.fb, Furrer, H.J.fb, Gorgievski, M.fb, GĂĽnthard, H.fb, Hirschel, B.fb, Kaiser, L.fb, Kind, C.fb, Klimkait, T.fb, Lauper, U.fb, Opravil, M.fb, Paccaud, F.fb, Pantaleo, G.fb, Perrin, L.fb, Piffaretti, J.C.fb, Rickenbach, M.fb, Rudin, C.fb, SchĂĽpbach, J.fb, Speck, R.fb, Tarr, P.fb, Telenti, A.fb, Trkola, A.fb, Vernazza, P.fb, Yerly, S.fb, de Wolf, F.ci, van Sighem, A.I.ci, van Valkengoed, I.ci, Gras, L.ci, Bronsveld, W.ci, Veldkamp, A.ci, Prins, J.M.cj, Bos, J.C.cj, Schattenkerk Eeftinck, J.K.M.cj, Godfried, M.H.cj, Lange, J.M.A.cj, Lowe, S.H.cj, van der Meer, J.T.M.cj, Nellen, F.J.B.cj, Pogany, K.cj, van der Poll, T.cj, Ruys, T.A.cj, Sankatsing, S.cj, van der Valk, M.cj, van Vonderen, M.G.A.cj, Wit, F.W.M.N.cj, van Eeden, A.cj, ten Veen, J.H.cj, van Dam, P.S.cj, Hillebrand-Haverkort, M.E.cj, Brinkman, K.cj, Frissen, P.H.J.cj, Weigel, H.M.cj, Mulder, J.W.cj, van Gorp, E.C.M.cj, Meenhorst, P.L.cj, Mairuhu, A.T.A.cj, Veenstra, J.cj, Danner, S.A.cj, Van Agtmael, M.A.cj, Claessen, F.A.P.cj, Geerlings, S.E.cj, Perenboom, R.M.cj, Jurriaans, S.cj, Back, N.K.T.cj, Cuijpers, T.cj, Rietra, P.J.G.M.cj, Roozendaal, K.J.cj, Pauw, W.cj, van Zanten, A.P.cj, Smits, P.H.M.cj, von Blomberg, B.M.E.cj, Savelkoul, P.cj, Zaaijer, H.cj, Beijnen, J.H.cj, Crommentuyn, K.M.L.cj, Huitema, A.D.R.cj, Kappelhoff, B.cj, de Maat, M.M.R.cj, Richter, C.ck, van der Berg, J.ck, van Leusen, R.ck, Swanink, C.ck, Vriesendorp, R.cl, Jeurissen, F.J.F.cl, Kauffmann, R.H.cm, Koger, E.L.W.cm, Franck, P.F.H.cm, Lampe, A.S.cm, Jansen, C.L.cm, Bravenboer, B.cn, ten Napel, C.H.H.co, Mudrikova, T.co, Hendriks, R.co, Sprenger, H.G.cp, Miesen, W.M.A.J.cp, Schirm, J.cp, Benne, D.cp, ten Kate, R.W.cq, Veenendaal, D.cq, van Houte, D.P.F.cr, Leemhuis, M.P.cr, Pole, M.cr, Storm, H.cr, van Zeijl, J.H.cr, Kroon, F.P.cs, Schippers, E.F.cs, Kroes, A.C.M.cs, Claas, H.C.J.cs, Schreij, G.ct, van de Geest, S.ct, Verbon, A.ct, Bruggeman, C.A.M.V.A.ct, Goossens, V.J.ct, Koopmans, P.P.cu, Telgt, M.cu, van der Ven, A.J.A.M.cu, Burger, D.M.cu, Hugen, P.W.H.cu, Galama, J.M.D.cu, Poort, Y.A.G.M.cu, van der Ende, M.E.cv, Gyssens, I.C.cv, de Marie, S.cv, Nouwen, J.L.cv, Niesters, M.G.cv, Osterhaus, A.D.M.E.cv, Schutten, M.cv, Juttmann, J.R.cw, Buiting, A.G.M.cw, Swaans, C.A.M.cw, Schneider, M.M.E.cx, Bonten, M.J.M.cx, Borleffs, J.C.C.cx, Hoepelman, I.M.cx, Jaspers, C.A.J.J.cx, Schouten, I.cx, Schurink, C.A.M.cx, Boucher, C.A.B.cx, Schuurman, R.cx, Blok, W.L.cy, Groeneveld, P.H.P.cz, Boel, E.da, Jansz, A.F.da, Dabis, F.db, Thiebaut, R.db, ChĂŞne, G.db, Lawson-Ayayi, S.db, Meyer, L.dc, Boufassa, F.dc, Hamouda, O.dd, Pezzotti, P.de, Rezza, G.de, Touloumi, G.df, Hatzakis, A.df, Karafoulidou, A.df, Katsarou, O.df, Brettle, R.dg, Del Amo, J.dh, del Romero, J.dh, van Asten, L.di, van Benthem, B.di, Prins, M.di, Coutinho, R.di, Kirk, O.dj, Pedersen, C.dj, Hernández Aguado, I.dk, PĂ©rez-Hoyos, S.dk, Eskild, A.dl, Bruun, J.N.dl, Sannes, M.dl, Lee, C.dm, Johnson, A.M.dn, Babiker, A.dn, Darbyshire, J.dn, Gill, N.dn, Porter, K.dn, Francioli, P.do, Vanhems, P.do, Egger, M.do, Rickenbach, M.do, Cooper, D.dp, Kaldor, J.dpdq, Ashton, L.dp, Cooper, D.dq, Ashton, L.dq, Vizzard, J.dq, Muga, R.dr, Vanhems, P.ds, Gill, J.dt, Cayla, J.du, Garcia de Olalla, P.du, Day, N.E.dv, De Angelis, D.dv, Porter, K.fb, Babiker, A.dw, Walker, S.dw, Darbyshire, J.dw, Tyrer, F.dw, Beral, V.fb, Coutinho, R.fb, Darbyshire, J.fb, Del Amo, J.fb, Gill, N.fb, Lee, C.fb, Meyer, L.fb, Rezza, G.fb, Raffanti, S.fb, Becker, S.fb, Scarsella, A.fb, Braun, J.fb, Most, B.fb, Balu, R.fb, Gilbert, L.fb, Fleenor, R.fb, Ising, T.fb, Dieterich, D.fb, Fusco, J.fb, Losso, M.dx, Duran, A.dx, Vetter, N.dy, Clumeck, N.dz, De Wit, S.dz, Kabeya, K.dz, Poll, B.dz, Colebunders, R.dz, Machala, L.ea, Rozsypal, H.ea, Nielsen, J.eb, Lundgren, J.eb, Kirk, O.eb, Olsen, C.H.eb, Gerstoft, J.eb, Katzenstein, T.eb, Hansen, A.-B.E.eb, Skinhøj, P.eb, Pedersen, C.eb, Zilmer, K.ec, Rauka, M.ec, Katlama, C.ed, De Sa, M.ed, Viard, J.-P.ed, Saint-Marc, T.ed, Vanhems, P.ed, Pradier, C.ed, Dietrich, M.ee, Manegold, C.ee, van Lunzen, J.ee, Stellbrink, H.-J.ee, Miller, V.ee, Goebel, F.-D.ee, Salzberger, B.ee, Rockstroh, J.ee, Kosmidis, J.ef, Gargalianos, P.ef, Sambatakou, H.ef, Perdios, J.ef, Panos, G.ef, Filandras, A.ef, Banhegyi, D.eg, Mulcahy, F.eh, Yust, I.ei, Burke, M.ei, Pollack, S.ei, Hassoun, J.ei, Sthoeger, Z.ei, Maayan, S.ei, Vella, S.ej, Chiesi, A.ej, Arici, C.ej, Pristerá, R.ej, Mazzotta, F.ej, Gabbuti, A.ej, Esposito, R.ej, Bedini, A.ej, Chirianni, A.ej, Montesarchio, E.ej, Vullo, V.ej, Santopadre, P.ej, Narciso, P.ej, Antinori, A.ej, Franci, P.ej, Zaccarelli, M.ej, Lazzarin, A.ej, Castagna, A.ej, Viksna, L.ek, Rozentale, B.ek, Chaplinskas, S.el, Hemmer, R.em, Staub, T.em, Bruun, J.en, Maeland, A.en, Ormaasen, V.en, Knysz, B.eo, Gasiorowski, J.eo, Horban, A.eo, Prokopowicz, D.eo, Wiercinska-Drapalo, A.eo, Boron-Kaczmarska, A.eo, Pynka, M.eo, Beniowski, M.eo, Trocha, H.eo, Smiatacz, T.eo, Antunes, F.ep, Mansinho, K.ep, Maltez, F.ep, Duiculescu, D.eq, Streinu-Cercel, A.eq, Mokrás, M.er, Staneková, D.er, González-Lahoz, J.es, Diaz, B.es, GarcĂa-Benayas, T.es, Martin-Carbonero, L.es, Soriano, V.es, Clotet, B.es, Jou, A.es, Conejero, J.es, Tural, C.es, Gatell, J.M.es, MirĂł, J.M.es, Zamora, L.es, Blaxhult, A.et, Karlsson, A.et, Pehrson, P.et, Francioli, P.eu, Hirschel, B.eu, Schiffer, V.eu, Furrer, H.eu, Chentsova, N.ev, Barton, S.ew, Johnson, A.M.ew, Mercey, D.ew, Phillips, A.ew, Youle, M.ew, Johnson, M.A.ew, Mocroft, A.ew, Murphy, M.ew, Weber, J.ew, Scullard, G.ew, Fisher, M.ew, Brettle, R.ew, Loveday, C.ew, Clotet, B.ex, Ruiz, L.ex, Helm, E.B.fb, Carlebach, A.fb, Mösch, M.fb, MĂĽller, A.fb, Haberl, A.fb, Korn, S.fb, Stephan, C.fb, Bickel, M.fb, Gute, P.fb, Locher, L.fb, Lutz, T.fb, Klauke, S.fb, Doerr, H.W.fb, StĂĽrmer, M.fb, Dauer, B.fb, Jennings, B.fb, Alexander, C.fb, Braitstein, P.fb, Chan, K.fb, Cote, H.fb, Gataric, N.fb, Harrigan, P.R.fb, Harris, M.fb, Bonner, S.fb, Montaner, J.fb, O'Shaughnessy, M.fb, Wood, E.fb, Yip, B.fb, Chaloner, C.fb, Gumley, H.fb, Ransom, D.fb, Sabin, C.A.fb, Mocroft, A.fb, Lipman, M.fb, Youle, M.fb, Johnson, M.fb, Gill, J.ey, Read, R.ey, Mazzotta, F.ez, Riccio, G.fa, Borghi, V.fb, Bedini, A.fb, Esposito, R.fb
- Sabin C
- Staszewski S
- Walker AS
- Weber R
- Wit F
- Publication venue
- Lancet Limited:42 Bedford Square, London WC1B 3SL United Kingdom:011 44 207 4364981, EMAIL: [email protected], INTERNET: http://www.thelancet.com, Fax: 011 44 207 3236433
- Publication date
- 01/01/2004
- Field of study