309 research outputs found
A novel medium size lactam ring analoges as antibacterial agents
A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione (6a-f) analogues
were synthesized from (E)-3-(2-nitrophenyl)acrylicacid (2) reacting with various amino acid esters using
Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried out by using reagent 1-Ethyl-3(3-
dimethylaminopropyl) Carbodiimide Hydrochloride. The synthesized compounds have been supported by Mass,
1H-NMR and 13C-NMR. Further antibacterial studies were conducted, where some molecules are noticed with
potent activity, especially molecule 6d shown highest activity which was also supported by molecular docking
studies. All final molecules were docked with enzyme peptide deformylase to determine the probable binding
conformation
Effect of temperature and time on paramagnetic resonance of Mn<SUP>2+</SUP> in NaCl single crystal
Exchange of intensities among various spectra of Mn2+ in NaCl single crystal, corresponding to Mn+2 ion associated with various point defects, is described as a function of temperature and time. The variation of line width with temperature is discussed. The fine structure parameter D for a particular spectrum is measured with temperature and is shown to behave like D=D0 (1+bT+cT2). Thermal formation of new complexes and their lifetimes are discussed. A new short-lived complex is found and a model for the same is suggested
Effect of antiorthostatic BedRest (BR) on GastroIntestinal Motility (GIM) of normal subjects
The combined effects of postural changes, fluid shifts and diuresis associated with the absence of the gravity vector may decrease gastrointestinal motility (GIM) during space flight. GIM can be estimated from the mouth to cecum transit time (MCTT) of orally administered lactulose (LAC); this test is used to assess changes in GIM in normal subjects and in patients with GI pathology and related disease conditions. Since bedrest (BR) mimics some of the physiological changes that occur during space flight, the effect of ten days of BR on GIM was evaluated from the MCTT of LAC. Methods: Subjects were 12 nonsmoking males between the ages of 35 and 50. After an 8-10 hour fast, subjects ingested Cephulac (registered) (20 g solution) with a low-fiber breakfast on four different days (45, 30, 25, and 20) before BR and on three separate days (4, 7, and 10) during BR. Breath-H2 concentrations were measured before and at 10 minute intervals for 4 hours after breakfast using a Quintron breathalyzer and MCTT was determined from these data. Results: MCTT ranged between 10 and 122 minutes during ambulation and 80 to 120 minutes during BR with means of 79 minutes and 122 minutes respectively. Conclusion: Mean MCTT during BR was 54 percent longer than during ambulation, suggesting that absorption and availability of orally administered medications and nutrients may be delayed or impaired as a result of decreased GIM during bedrest
Scattering of rare-gas atoms at a metal surface: evidence of anticorrugation of the helium-atom potential-energy surface and the surface electron density
Recent measurements of the scattering of He and Ne atoms at Rh(110) suggest
that these two rare-gas atoms measure a qualitatively different surface
corrugation: While Ne atom scattering seemingly reflects the electron-density
undulation of the substrate surface, the scattering potential of He atoms
appears to be anticorrugated. An understanding of this perplexing result is
lacking. In this paper we present density functional theory calculations of the
interaction potentials of He and Ne with Rh(110). We find that, and explain
why, the nature of the interaction of the two probe particles is qualitatively
different, which implies that the topographies of their scattering potentials
are indeed anticorrugated.Comment: RevTeX, 4 pages, 10 figure
Electron paramagnetic resonance studies of photorefractive crystals II: Fe<SUP>3+</SUP> doped Bi<SUB>12</SUB>SiO<SUB>20</SUB> with copper vapour laser illumination in 10-100 K range
Photo-induced charge transfer and its kinetics were investigated in Bi12SiO20 in 10-300 K temperature range, using EPR of Fe3+ centre, underin situ illumination with copper vapour laser (CVL). The decay kinetics was found to follow double exponential behaviour. Relaxation of the photo-induced electron transfer to the preillumination condition occurred even at 10 K. Shallow traps were, therefore, associated with the electron trapping, leading to a better understanding of the fast photorefractive response of BSO
Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria. We show that expression of Trim17 is increased both at the mRNA and protein level in several in vitro models of transcription-dependent neuronal apoptosis. Expression of Trim17 is controlled by the PI3K/Akt/GSK3 pathway in cerebellar granule neurons (CGN). Moreover, the Trim17 protein is expressed in vivo, in apoptotic neurons that naturally die during post-natal cerebellar development. Overexpression of active Trim17 in primary CGN was sufficient to induce the intrinsic pathway of apoptosis in survival conditions. This pro-apoptotic effect was abolished in Bax(-/-) neurons and depended on the E3 activity of Trim17 conferred by its RING domain. Furthermore, knock-down of endogenous Trim17 and overexpression of dominant-negative mutants of Trim17 blocked trophic factor withdrawal-induced apoptosis both in CGN and in sympathetic neurons. Collectively, our data are the first to assign a cellular function to Trim17 by showing that its E3 activity is both necessary and sufficient for the initiation of neuronal apoptosis. Cell Death and Differentiation (2010) 17, 1928-1941; doi: 10.1038/cdd.2010.73; published online 18 June 201
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