A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7 (8H)-ones

Wheland intermediates are usually unstable compounds and only a few have been isolated at very low temperatures. During our work on tyrosine kinase inhibitors, we studied the bromination of 7 in order to obtain a dibromo substituted pyrido[2,3-d]pyrimidin-7(8H)-one which could be orthogonally decorated. Surprisingly, treatment of 7 with 3 equiv. of Br2 in acetic acid (AcOH) afforded 12, a captured room temperature stable Wheland bromination intermediate stabilized by the bromination of the imino tautomer of the amino group at C4 of the pyridopyrimidine skeleton. The structure was confirmed by crystal structure determination from powder X-ray diffraction data. Treatment of 12 with DMSO afforded the dibromo substituted compound 13 presenting a bromine atom at C6 and C5-C6 unsaturation. 13 was directly accessed by treating 7 with N-bromosuccinimide (NBS), a protocol extended to other compounds using NBS or N-iodosuccinimide (NIS) to afford 6-halo substituted systems. 26, bearing an iodine at C6 and a p-bromophenylamino at C2, allows the orthogonal decoration of pyridopyrimidines

Blue space as caring space – water and the cultivation of care in social and environmental practice

This paper studies three sites or ‘landscapes of care’ in Leeds, Bristol and London where water and associated built and natural environments are used to co-construct and facilitate forms of social and environmental care. Our research narrates the ways in which blue spaces are cultivated for the production of particular forms of caring bodies and sensibilities. Interpreting care as both a doing (caring for) and emotion (caring about), we draw attention to the diverse practices and distributed nature of care in these environments. Our paper has three main insights. First, we draw attention to the role of water as both a material and site of care. Second, we identify a range of more-than-human benefits associated with blue spaces and how these emerge via collaborative, non-linear and reciprocal forms of care. Third, we argue that by understanding how care works in everyday social practice, new forms of ecological care and pro-environmental ways of living with the world can emerge

Affective practices, care and bioscience: a study of two laboratories

Scientific knowledge-making is not just a matter of experiments, modelling and fieldwork. It also involves affective, embodied and material practices (Wetherell 2012) which can be understood together as 'matters of care' (Puig de la Bellacasa, 2011). In this paper we explore how affect spans and connects material, subjective and organisational practices, focusing in particular on the patterns of care we encountered in an observational study of two bioscience laboratories. We explore the preferred emotional subjectivities of each lab and their relation to material practice. We go on to consider flows and clots in the circulation of affect and their relation to care through an exploration of belonging and humour in the labs. We show how being a successful scientist or group of researchers involves a careful choreography of affect in relation to materials, colleagues and others to produce scientific results, subjects and workplaces. We end by considering how thinking with care troubles dominant constructions of scientific practice, successful scientific selves and collectives

Violence and creation: the recovery of the body in the work of Elaine Scarry

Elaine Scarry’s book The Body in Pain justly deserves it place as one the pivotal works that opened up the field of ‘body studies’. The text needs to be evaluated in the retrospective terms of the field it established, and also with respect to the changing status of both ‘torture’ and ‘war’ in contemporary state politics. Scarry’s analysis of the relationship between making and unmaking, tools and weapons, under-estimates the reversibility and the situated relational character of these processes and artefacts. The changing nature of modern conflict, and the rising concern with global terrorism rather than ‘conventional’ and ‘nuclear’ war, makes the ‘referential instability’ of the body difficult to recuperate in post-conflict discourse. At the same, the normalisation of the logic of torture in the contemporary governance of the bodies of the most vulnerable in society makes Scarry’s analysis all the more prescient

Caring for soil life in the Anthropocene: the role of attentiveness in more-than-human ethics

This paper considers the work that attentiveness can and can’t do in generating more ethical relations with non-humans. How to build better relations with non-humans has been a central debate in geography and cognate disciplines. These concerns include ethical relations with non-humans who both pervade and create liveable environments, such as soil biota. Scholars have specifically identified attentiveness as key in generating more-than-human ethics. However, how attentiveness may arise, and what work attentiveness may be able to do in generating ethical relations has not been sufficiently explored. Additionally, soils as relational materialities remain underexplored in social sciences. In this paper, I address these two important gaps in scholarship. Investigating the rising concern with soil biota in conventional English farming, I propose the care network as a way of conceptualising and investigating the ethical potential of attentiveness. As concerns grow about soil degradation, and the dangers this is posing to food production and to human survival, land managers are attending to soil ecosystems as part of caring for their farm businesses. While this attentiveness is producing some transformative effects, its potential is limited by the configuration of the soil care network. As long as soil care is configured primarily as a farmers’ concern, the potential of attentiveness in generating ethical regard to the needs of soil biota will be limited. In the conclusions, I suggest ways of expanding attentiveness to soils, and building a wider and practical relational ethic of soil care. I also argue we need more attention in geographic research to attentiveness and care as systemic, unequally distributed, and operating at multiple scales

Re-Shape: A Method to Teach Data Ethics for Data Science Education

Data has become central to the technologies and services that human-computer interaction (HCI) designers make, and the ethical use of data in and through these technologies should be given critical attention throughout the design process. However, there is little research on ethics education in computer science that explicitly addresses data ethics. We present and analyze Re-Shape, a method to teach students about the ethical implications of data collection and use. Re-Shape, as part of an educational environment, builds upon the idea of cultivating care and allows students to collect, process, and visualizetheir physical movement data in ways that support critical reflection and coordinated classroom activities about data, data privacy, and human-centered systems for data science. We also use a case study of Re-Shape in an undergraduate computer science course to explore prospects and limitations of instructional designs and educational technology such as Re-Shape that leverage personal data to teach data ethics

Science under Siege? Being alongside the life sciences, giving science life

The aim in this paper is to explore conditions of possibility for giving life to science in the context of science being under siege from twin agendas of industrialization and managerialization. The focus of this exploration is my experiencing a shift from being brought in as an ally in the strategic conduct of others to then becoming engaged in the life sciences of ageing. In nuancing these different ways of ‘being alongside’ (Latimer 2013), I show how social and life scientist’s attachment and detachment to things can bring them into an intimate entanglement with each other’s world-making. Keeping in view possibilities for breaching the dividing practices by which each of us are emplaced, as either life scientist or social scientist, I focus on gatherings that give science life and so get beyond things as “as others want them”