Area espositiva del progetto 3DLab-Sicilia

Il documento fornisce suggerimenti circa le dimensioni dell’area espositiva del progetto 3DLab-Sicilia e gli arredi e le attrezzature da installare in tale area

L’architettura e l’immagine dei luoghi. Esplorazioni dello spazio attraverso la fotografia

Il lavoro riguarda il progetto grafico del volume che costituisce l’attività conclusiva e di sintesi della ricerca condotta nel 2007 dall'Università degli Studi di Palermo, con il Corso di laurea in Ingegneria Edile/Architettura di Palermo ed il Corso di laurea in Architettura - sede di Agrigento, in collaborazione con l'Azienda Regionale Foreste Demaniali, e con l'attiva partecipazione dell'Amministrazione comunale di Santo Stefano Quisquina. Il libro raccoglie i contributi sulla cultura dell’immagine e della fotografia (elaborati in seno al seminario Architettura e Fotografia), e i risultati della ricerca fotografica sull'architettura ed i luoghi nella Riserva Naturale Orientata 'Monte Cammarata' ed a Santo Stefano Quisquina (svolta nel laboratorio Natura e Architettura)

Genomic Adaptation of Local Cattle Breeds in the Alpine Massif

Understanding adaptive ability of livestock is a key factor in the context of global climate change and become a crucial focus in conservation and management for a sustainable farming in a changing environment. One way to better understand adaptation abilities is to identify genes underlying adaptation phenotypes. This goal can be achieved by genetically characterising livestock species and detecting footprints of selection in the animal genome. The recent availability of genome-wide SNP panels allows providing background information concerning genome structure in domestic animals, opening new perspectives to livestock genetics. In order to investigate the genetic regions with a potential adaptive role, we investigate 24 cattle breeds, (high productive specialised breeds and several autochthonous populations) reared in six different neighbouring nations from East to West Alpine Massif. Several analyses have been performed to detect footprints of selection and genomic regions associated with climate variables. More precisely, using breed GPS coordinates, 4 climatic variables (annual mean temperature, annual precipitation, annual mean radiation, and annual mean moisture index) were extracted from the Climond database. In order to identify footprints of selection, a whole genome scan for adaptive differentiation were performed using Bovine 50K SNP chip genotyping data with the XtX model implemented in the BAYPASS software. In addition, across-population whole genome scans for association with the population-specific climatic variables were performed using the AUX model. Footprints of selection were detected on BTA6 and BTA18 pointing out several candidate genes (i.e. LCORL, PDGFRA, KDR and SPG7); moreover different genomic regions (on BTA 6, 10, 19 and 20) were associated with annual mean radiation. Ongoing analyses will specify candidate regions and genes involved in local adaptation in the Alpine massif

Poprawa jakości życia i aktywności chorych na migrenę po leczeniu profilaktycznym. Wieloośrodkowe, długotrwałe badanie prospektywne

Głównym celem w leczeniu migreny jest poprawa jakości życia warunkowanej stanem zdrowia (HRQOL, health-related quality of life) i zmniejszenie ograniczeń aktywności. Brakuje jednak danych dotyczących wpływu leczenia profilaktycznego na wymienione parametry. U 141 kolejno zgłaszających się pacjentów z migreną bez aury, u których stosowano leczenie profilaktyczne, autorzy monitorowali zmiany HRQOL przy użyciu kwestionariusza Short Form 36 (SF-36) i ograniczenie aktywności związane z bólami głowy za pomocą kwestionariusza Migraine Disability Assessment Score (MIDAS). Trwające 3 miesiące badanie ukończyło łącznie 102 pacjentów. Średnia (SD, standard deviation) liczba dni z bólami głowy w ciągu miesiąca zmniejszyła się z 8,0 (3,7) do 5,0 (2,3) (p < 0,001). Średnie miesięczne stosowanie leków doraźnych zmalało z 7,4 (3,5) do 4,4 (3,1) (p < 0,001). Całkowity wynik w skali MIDAS zmniejszył się znacząco (poprawa). Wszystkie wyniki uzyskane z użyciem skal SF-36 wzrosły (poprawa), przy czym większość z nich w sposób znaczący. Jest to pierwsze badanie, w którym prospektywnie oceniono wpływ leczenia profilaktycznego na HRQOL i aktywność codzienną w dużej serii grupie chorych. Wskazuje ono, że leczenie profilaktyczne może zmniejszyć indywidualne i społeczne obciążenia związane z migreną

Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Vomiting in children with acute gastroenteritis (AG) is not only a direct cause of fluid loss but it is also a major factor of failure of oral rehydration therapy (ORT). Physicians who provide care to paediatric patients in the emergency department (ED) usually prescribe intravenous fluid therapy (IVT) for mild or moderate dehydration when vomiting is the major symptom. Thus, effective symptomatic treatment of vomiting would lead to an important reduction in the use of IVT and, consequently, of the duration of hospital stay and of frequency of hospital admission. Available evidence on symptomatic treatment of vomiting shows the efficacy of the most recently registered molecule (ondansetron) but a proper evaluation of antiemetics drugs largely used in clinical practice, such as domperidone, is lacking.</p> <p>Objectives</p> <p>To compare the efficacy of ondansetron and domperidone for the symptomatic treatment of vomiting in children with AG who have failed ORT.</p> <p>Methods/Design</p> <p>Multicentre, double-blind randomized controlled trial conducted in paediatric EDs. Children aged from 1 to 6 years who vomiting, with a presumptive clinical diagnosis of AG, and without severe dehydration will be included. After the failure of a initial ORS administration in ED, eligible children will be randomized to receive: 1) ondansetron syrup (0,15 mg/Kg of body weight); 2) domperidone syrup (0,5 mg/Kg of body weight); 3) placebo. The main study outcome will be the percentage of patients needing nasogastric or IVT after symptomatic oral treatment failure, defined as vomiting or fluid refusal after a second attempt of ORT. Data relative to study outcomes will be collected at 30 minute intervals for a minimum of 6 hours. A telephone follow up call will be made 48 hours after discharge. A total number of 540 children (i.e. 180 patients in each arm) will be enrolled.</p> <p>Discussion</p> <p>The trial results would provide evidence on the efficacy of domperidone, which is largely used in clinical practice despite the lack of proper evaluation and a controversial safety profile, as compared to ondansetron, which is not yet authorized in Italy despite evidence supporting its efficacy in treating vomiting. The trial results would contribute to a reduction in the use of IVT and, consequently, in hospital admissions in children with AG. The design of this RCT, which closely reflect current clinical practice in EDs, will allow immediate transferability of results.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01257672">NCT01257672</a></p