Terzyme: a tool for identification and analysis of the plant terpenome.

BACKGROUND: Terpenoid hydrocarbons represent the largest and most ancient group of phytochemicals, such that the entire chemical library of a plant is often referred to as its 'terpenome'. Besides having numerous pharmacological properties, terpenes contribute to the scent of the rose, the flavors of cinnamon and the yellow of sunflowers. Rapidly increasing -omics datasets provide an unprecedented opportunity for terpenome detection, paving the way for automated web resources dedicated to phytochemical predictions in genomic data. RESULTS: We have developed Terzyme, a predictive algorithm for identification, classification and assignment of broad substrate unit to terpene synthase (TPS) and prenyl transferase (PT) enzymes, known to generate the enormous structural and functional diversity of terpenoid compounds across the plant kingdom. Terzyme uses sequence information, plant taxonomy and machine learning methods for predicting TPSs and PTs in genome and proteome datasets. We demonstrate a significant enrichment of the currently identified terpenome by running Terzyme on more than 40 plants. CONCLUSIONS: Terzyme is the result of a rigorous analysis of evolutionary relationships between hundreds of characterized sequences of TPSs and PTs with known specificities, followed by analysis of genome-wide gene distribution patterns, ontology based clustering and optimization of various parameters for building accurate profile Hidden Markov Models. The predictive webserver and database is freely available at http://nipgr.res.in/terzyme.html and would serve as a useful tool for deciphering the species-specific phytochemical potential of plant genomes

Optimizing Gingival Biotype Using Subepithelial Connective Tissue Graft: A Case Report and One-Year Followup

Gingival recession is the exposure of root surfaces due to apical migration of the gingival tissue margins. The principal objectives of treating a gingival recession are to achieve better esthetics and reduce hypersensitivity. The gingival biotype is an important modifying factor in the treatment of gingival recession. The purpose of this paper is to highlight the significance of changing the soft tissue biotype to a more favorable one while attempting root coverage, to achieve more stable and long-lasting results using subepithelial connective tissue graft

Periodontal Considerations in the placement of Dental Implants

The creation of an esthetic implant restoration with gingival architecture that harmonizes with the adjacent dentition is a formidable challenge. The predictability of the peri-implant esthetic outcome may ultimately be determined by the patient’s own presenting anatomy rather than the clinician’s ability to manage state-of-the-art procedures. To more accurately predict the peri-implant esthetic outcome before removing a failing tooth, five diagnostic keys are discussed. These keys include relative tooth position, form of the periodontium, biotype of the periodontium, tooth shape and position of the osseous crest.   KEYWORDS:  Dental Implants, Periodontal, Peri-implan

Updating non-standard neutrinos properties with Planck-CMB data and full-shape analysis of BOSS and eBOSS galaxies

Using the latest observational data from Planck-CMB and its combination with the pre-reconstructed full-shape (FS) galaxy power spectrum measurements from the BOSS DR12 sample and eBOSS LRG DR16 sample, we report the observational constraints on the cosmic neutrino properties given by the extended $\Lambda$CDM scenario: $\Lambda$CDM + $N_{\rm eff}$ + $\sum m_{\nu}$ + $c^2_{\rm eff}$ + $c^2_{\rm vis}$ + $\xi_{\nu}$, and its particular case $\Lambda$CDM + $c^2_{\rm eff}$ + $c^2_{\rm vis}$ + $\xi_{\nu}$, where $N_{\rm eff}$, $\sum m_{\nu}$, $c^2_{\rm eff}$, $c^2_{\rm vis}$, $\xi_{\nu}$ are the effective number of species, the total neutrino mass, the sound speed in the neutrinos rest frame, the viscosity parameter and the degeneracy parameter quantifying a cosmological leptonic asymmetry, respectively. We observe that the combination of FS power spectrum measurements with the CMB data significantly improves the parametric space of the models compared to the CMB data alone case. We find no evidence for neutrinos properties other than the ones predicted by the standard cosmological theory. Our most robust observational constraints are given by CMB + BOSS analysis. For the generalized extended $\Lambda$CDM scenario, we find $c^2_{\rm eff}=0.3304^{+0.0064}_{-0.0075}$, $c^2_{\rm vis}=0.301^{+0.037}_{-0.033}$, $\xi_{\nu} < 0.05$, $N_{\rm eff}=2.90 \pm 0.15$ at 68\% CL, with $\sum m_{\nu} < 0.116$ eV at 95\% CL. These are the strongest limits ever reported for these extended $\Lambda$CDM scenarios.Comment: 22 pages, 4 figures, 3 tables; Substantial changes in the text with updated results; matches the version published in JCAP except some additional refs in this versio

New cosmological constraints on f(T)f(T) gravity in the light of full Planck-CMB and type Ia Supernovae data

We investigate two new observational perspectives in the context of torsional gravitational modification of general relativity, i.e., the $f(T)$ gravity: i) We use Pantheon data of type Ia supernovae motivated by a time variation of the Newton's constant on the supernovae distance modulus relation, and find that a joint analysis with Baryon Acoustic Oscillations (BAO) and Big Bang Nucleosynthesis (BBN), i.e., Pantheon+BAO+BBN, provides constraints on the effective free parameter of the theory to be well compatible with the $\Lambda$CDM prediction; ii) We present the framework of $f(T)$ gravity at the level of linear perturbations with the phenomenological functions, namely the effective gravitational coupling $\mu$ and the light deflection parameter $\Sigma$, which are commonly used to parameterize possible modifications of the Poisson equation relating the matter density contrast to the lensing and the Newtonian potentials, respectively. We use the available Cosmic Microwave Background (CMB) data sets from the Planck 2018 release to constrain the free parameters of the $f(T)$ gravity and $\Lambda$CDM models. We find that CMB data, and its joint analyses with Pantheon and BAO data constrain the $f(T)$ gravity scenario to be practically indistinguishable from the $\Lambda$CDM model. We obtain the strongest limits ever reported on $f(T)$ gravity scenario at the cosmological level.Comment: 18 pages, 2 tables, 5 figure

Video assisted thoracoscopy surgery a viable alternative for duplication cyst excision: a case report on foregut duplication cyst

Alimentary tract duplication is a relatively uncommon congenital abnormality. It can be found anywhere from the mouth to the anus and can be symptomatic or undetectable. Although congenital duplication can happen anywhere in the gastrointestinal tract, the ileum, oesophagus, and colon are the most common locations. The foregut, which includes the stomach, and first and second segments of the duodenum, is the source of one-third of all duplications. When foregut duplication involves the bronchial tree, respiratory symptoms are often present. Furthermore, excision through surgery is required for pathological examination of the resected specimen for definitive diagnosis. The most promising surgical approach for cyst excision has been thought to be open surgical resection through a posterolateral thoracotomy incision. However, video assisted thoracoscopy surgery has recently emerged as a viable surgical option for duplication cyst removal In paediatric surgery, video assisted thoracoscopy surgery has been established to facilitate the removal of mediastinal masses. However there is a limitation of research in the literature regarding the best surgical technique for oesophageal duplication cyst excision. In girls, foregut duplication is more common, especially in cases when bronchopulmonary involvement is present. While many duplications result in issues in early development, some are discovered by accident. When foregut duplication involves the bronchial tree, respiratory symptoms are often present. Haemoptysis and respiratory distress may be present in specific cases of the patient. Here, we described a 5-year-old male infant's case of foregut duplication with bronchial involvement and its management

A Novel Method of Butterfly Optimization Algorithm for Load Balancing in Cloud Computing

Cloud computing is frequently alluded to as a model that furnishes boundless information handling conveniences with a compensation for each utilization framework. Present day cloud foundations resources as virtual machines (VMs) to actual machines utilizing virtualization innovation. All VMs works their involved structure and exhaust resources from their actual machine which behaves like a host. For load adjusting, Cloud moves VMs from exceptionally troubled real machines to low troubled actual machines. The delay of this calculation expansions in the organization as virtual machines are relocated. This work puts forward a new algorithm, namely Butterfly optimization for VM migration. The proposed optimization algorithm has been implemented in the MATLAB software. &nbsp;A comparative analysis is performed between the outcomes of the preceding and the new algorithm.&nbsp; The proposed algorithm has been evaluated over three performance parameters including delay, bandwidth used, and space used

New cosmological constraints on f(T) gravity in light of full Planck-CMB and type Ia supernovae data

We investigate two new observational perspectives in the context of torsional gravitational modification of general relativity, i.e., the f(T) gravity: (i) We use Pantheon data of type Ia supernovae motivated by a time variation of the Newton’s constant on the supernovae distance modulus relation, and find that a joint analysis with baryon acoustic oscillations (BAO) and big bang nucleosynthesis (BBN), i.e., Pantheon + BAO + BBN , provides constraints on the effective free parameter of the theory to be well compatible with the Λ CDM prediction; (ii) We present the framework of f(T) gravity at the level of linear perturbations with the phenomenological functions, namely the effective gravitational coupling μ and the light deflection parameter Σ , which are commonly used to parametrize possible modifications of the Poisson equation relating the matter density contrast to the lensing and the Newtonian potentials, respectively. We use the available cosmic microwave background (CMB) datasets from the Planck 2018 release to constrain the free parameters of the f(T) power-law gravity and Λ CDM models. We find that CMB data, and its joint analyses with Pantheon and BAO data constrain the f(T) power-law gravity scenario to be practically indistinguishable from the Λ CDM model. We obtain the strongest limits ever reported on f(T) power-law gravity scenario at the cosmological level

New late-time constraints on f(R)f(R) gravity

Modification of general relativity (GR) inspired by theories like $f(R)$ gravity is among the most popular ones to explain the late-time acceleration of the Universe as an alternative to the $\Lambda$CDM model. In this work, we use the state-of-the-art BAO+BBN data and the most recent Type Ia supernovae (SNe Ia) sample namely PantheonPlus, including the Cepheid host distances and covariance from SH0ES samples, to robustly constrain the $f(R)$ gravity framework via two of the most popular $f(R)$ models in literature, namely, the Hu-Sawicki and Starobinsky models. Additionally, we consider how the time variation of the Newton's gravitational constant affects the supernovae distance modulus relation. We find a minor evidence for $f(R)$ gravity under the Hu-Sawicki dynamics from BAO+BBN and BAO+BBN+uncalibrated supernovae joint analysis, but the inclusion of Cepheid host distances, makes the model compatible with GR. Further, we notice tendency of this model to relax the $H_0$ tension. In general, in all the analyses carried out in this study with the late time probes, we find both the $f(R)$ models to be consistent with GR at 95\% CL.Comment: 9 pages, 3 figures, 1 table, matches the version published in Physics of Dark Univers