9 research outputs found
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
- Hallan Stein
- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G
- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
- Hillege Hans L
- Hilton Gina
- Hindorff Lucia
- Hingorani Aroon
- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
- Holm Hilma
- Holmen Oddgeir
- Homuth Georg
- Hopewell Jemma C
- Horikoshi Momoko
- Hosseini Mohsen
- Hottenga Jouke-Jan
- Hovingh G Kees
- Howard Philip
- Hsiung Chao Agnes
- Hsu Yi-Hsiang
- Hu Frank B
- Huang Huateng
- Huang Jinyan
- Hui Jennie
- Humphries Steve E
- Hundertmark Claudia
- Hung Yi-Jen
- Hunt Sarah E
- Hunt Steven C
- Hunter David J
- Husted Lise Bjerre
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl Wilmar
- Ikram M Arfan
- Illig Thomas
- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
- Isaacs Aaron
- Isakova Tamara
- Islam Muhammad
- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
- Johnson Paul C D
- Johnson Toby
- Jones Graeme
- Jones Michelle R
- Jousilahti Pekka
- Ju Sung Yun
- Jukema J Wouter
- Jula Antti
- Juliusdottir Thorhildur
- Justice Anne E
- Järvelin Marjo-Riitta
- Jöckel Karl-Heinz
- Kaakinen Marika
- Kahali Bratati
- Kalafati Ioanna-Panagiota
- Kaleebu Pontiano
- Kammerer Candace M
- Kanaya Alka
- Kang Hyun M
- Kang Hyun Min
- Kangas Antti J
- Kanoni Stavroula
- Kao Linda
- Kao W H L
- Kao Wen Hong Linda
- Kaplan Robert C
- Kaprio Jaakko
- Kaptoge Stephen K
- Kapur Karen A
- Karasik David
- Kardia Sharon L
- Karjalainen Juha
- Karlsson Magnus
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Katsareli Efi
- Kedenko Lyudmyla
- Kee Frank
- Keildson Sarah
- Keinanen-Kiukaanniemi Sirkka M
- Keller Benjamin J
- Kemp John P
- Kennedy Stephen H
- Kessler Thorsten
- Kestenbaum Bryan
- Kesäniemi Antero
- Ketkar Shamika
- Kettunen Johannes
- Keyzer Jules
- Khaw Kay-Tee
- Khusainova Rita
- Khusnutdinova Elza
- Kiel Douglas P
- Kiess Wieland
- Kilpeläinen Tuomas O
- Kim Eric
- Kim Ghi Su
- Kim Hyo-Soo
- Kim Hyung-Lae
- Kim Stuart K
- Kinnunen Leena
- Kinra Sanjay
- Kiryluk Krzysztof
- Kita Yoshikuni
- Kivimaki Mika
- Kizer Jorge R
- Klaric Irena Martinovic
- Kleber Marcus E
- Klopp Norman
- Kloppenburg Margreet
- Knowles David
- Knowles Joshua W
- Kocarnik Jonathan
- Koenig Wolfgang
- Koh Jung-Min
- Kolcic Ivana
- Koller Daniel L
- Kollerits Barbara
- Kollia Panagoula
- Kolonel Laurence
- Kolovou Genovefa
- Komulainen Pirjo
- Kong Augustine
- Kooner Ishminder K
- Kooner Jaspal
- Kooperberg Charles
- Koromila Theodora
- Koudstaal Peter J
- Kovacs Peter
- Kraft Peter
- Kraja Aldi T
- Kramer Holly
- Kratzer Wolfgang
- Krauss Ronald M
- Krestyaninova Maria
- Kretzler Matthias
- Kristiansson Kati
- Kroemer Heyo K
- Kronenberg Florian
- Kruk Marcin
- Krämer Bernhard K
- Kuh Diana
- Kulkarni Smita R
- Kuller Lew
- Kumar M J Kranthi
- Kumari Meena
- Kung Annie Wai Chee
- Kutalik Zoltan
- Kutalik Zoltán
- Kuulasmaa Kari
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kwan Tony
- Kytö Janne
- Kyvik Kirsten O
- Kähönen Mika
- König Inke R
- Körner Antje
- Köttgen Anna
- Laakso Markku
- Laaksonen Marika
- Laaksonen Reijo
- Laan Maris
- LaCroix Andrea
- Lacroix Andrea Z
- Ladenvall Claes
- Ladouceur Martin
- Lagou Vasiliki
- Lahermo Päivi
- Lahti Jari
- Lai Sandra
- Laisk Triin
- Laitinen Jaana
- Lajer Maria
- Lakatta Edward G
- Lakka Timo A
- Lambert Ann
- Lamina Claudia
- Langdahl Bente Lomholt
- Langefeld Carl D
- Langenberg Claudia
- Langford Cordelia
- Larson Martin
- Larson Martin G
- Lathrop Mark
- Lauc Lovorka Barac
- Launer Lenore
- Laven Joop S E
- Lawlor Debbie A
- Lawrence Robert W
- Le Marchand Loic
- Le Marchand Loïc
- Leak Tennille S
- Leander Karin
- Lecoeur Cecile
- Lee Ji-Young
- Lee Jong-Young
- Lee Nanette R
- Lee Sang Hong
- Lee Seung Hun
- Lefebvre Pierre
- Lehtimäki Terho
- Lehto Markku
- Leo Paul J
- Leslie William D
- Leung Ping C
- Levy Daniel
- Lewis Joshua R
- Li Guo
- Li Man
- Li Rui
- Li Shengxu
- Li Xiaohui
- Li Yali
- Liang Liming
- Lichtner Peter
- Lifton Richard P
- Lim Unhee
- Lin Danyu
- Lin Peng
- Lin Shih-Yi
- Lin Yi
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Lips Paul
- Liu Ching-Ti
- Liu Jianjun
- Liu Yongmei
- Ljunggren Östen
- Lobbens Stéphane
- Locke Adam E
- Lohman Kurt
- Lohman Kurt K
- Lokki Marja-Liisa
- Longstreth W T
- Loo Britt-Marie
- Loos Ruth J F
- Lopez Lorna M
- Lorenc Roman S
- Lorentzon Mattias
- Louwers Yvonne V
- Lowe Christopher E
- Lu Xiaoning
- Luan Jian'an
- Luben Robert
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- Ludwig Barbara
- Lumley Thomas
- Lundmark Anders
- Lundmark Per
- Lunetta Kathryn L
- Lyssenko Valeriya
- Lyytikainen Leo-Pekka
- Lyytikäinen Leo-Pekka
- Ma Baoshan
- MacCluer Jean
- Macgregor Stuart
- Mach François
- Maerz Winfried
- Maestroni Anna
- Maestroni Silvia
- Magnusson Patrik K E
- Mahajan Anubha
- Malinowski Jennifer
- Mangino Massimo
- Mani K Radha
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- Manolio Teri
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- Marette André
- Marmot Michael G
- Marongiu Mara
- Marre Michel
- Martin Finian
- Martin Nicholas G
- Marullo Letizia
- Masciullo Corrado
- Masi Laura
- Mateo Leach Irene
- Matise Tara
- Mattace-Raso Francesco U S
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- McArdle Patick F
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- McArdle Wendy L
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- McCloskey Eugene
- McKay Gareth J
- McKenzie Colin A
- McKnight Amy J
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- Medina-Gomez Carolina
- Medina-Gómez Carolina
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- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Melbye Mads
- Mellström Dan
- Melzer David
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- Meneton Pierre
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- Merger Sigrun
- Meschia James F
- Metspalu Andres
- Metzger Marie
- Meulenbelt Ingrid
- Mihai Ioana
- Mihailov Evelin
- Miki Tetsuro
- Milaneschi Yuri
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- Miljkovic Iva
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- Minelli Cosetta
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- Missmer Stacey A
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- Mitchell Paul
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- Moilanen Leena
- Monda Keri L
- Monroe Kristine
- Montasser May E
- Montgomery Grant W
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- Mora Samia
- Morken Mario A
- Morris Andrew D
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- Männistö Satu
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- Müller Gabriele
- Müller Gabrielle
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- Nestle Frank O
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- Nieminen Markku S
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- Nogues Xavier
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- Ntzani Evangelia E
- Nuotio Marja-Liisa
- Nyberg Fredrik
- Nyholt Dale R
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- O'Connell Jeffrey R
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- O'Rahilly Stephen
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- O'Seaghdha Conall M
- Obermayer-Pietsch Barbara
- Oei Ling
- Oetjens Matthew
- Ogihara Toshio
- Ohkubo Takayoshi
- Ohlsson Claes
- Okamura Tomonori
- Oksa Heikki
- Olafsson Isleifur
- Oldehinkel Albertine J
- Olden Matthias
- Olmos José M
- Olsson Christian
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- Oostra Ben A
- Ordovas Jose M
- Org Elin
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- Orru Marco
- Ouwehand Willem H
- Painter Jodie N
- Palmas Walter
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- Palmer Colin
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- Palmer Nicholette D
- Palotie Aarno
- Palsson Stefan Th
- Panduru Nicolae Mircea
- Pankow James
- Papamarkou Theodore
- Parish Sarah
- Park Jeong E
- Park Lani
- Parker Alex N
- Parkkonen Maija
- Parsa Afshin
- Parts Leopold
- Parving Hans-Henrik
- Paré Guillaume
- Pasko Dorota
- Pastinen Tomi
- Patel Millan S
- Paterson Andrew D
- Patsy Bruce
- Pattaro Cristian
- Paulweber Bernhard
- Peacock Munro
- Pechlivanis Sonali
- Peden John F
- Pedersen Nancy L
- Peeters Petra H M
- Peloso Gina M
- Peltonen Leena
- Pendergrass Sarah
- Pennell Craig E
- Penninx Brenda W
- Peralta Carmen A
- Perola Markus
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- Pers Tune H
- Person Sharina
- Peters Annette
- Peters Marjolein J
- Peters Ulrike
- Petersen Ann-Kristin
- Pettersson-Kymmer Ulrika
- Peyser Patricia A
- Pharoah Paul
- Pihur Vasyl
- Pirastu Mario
- Pistis Giorgio
- Pitkäniemi Janne
- Platou Carl G P
- Plump Andrew
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- Polasek Ozren
- Pols Huibert A P
- Pomilla Cristina
- Pop Victor J M
- Porcu Eleonora
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- Postma Dirkje S
- Potter Simon
- Pouta Anneli
- Power Chris
- Prabhakaran Dorairajan
- Pramstaller Peter P
- Prentice Ross
- Prezelj Janez
- Price Jackie F
- Prince Richard L
- Prior Sarah
- Probst-Hensch Nicole M
- Prokopenko Inga
- Province Michael
- Province Michael A
- Psaty Bruce
- Pérusse Louis
- Qi Lu
- Quertermous Thomas
- Quibrera Miguel
- Rader Daniel J
- Rafelt Suzanne
- Raffel Leslie J
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- Raitakari Olli
- Ralston Stuart H
- Randall Joshua C
- Rankinen Tuomo
- Rao D C
- Rao Dabeeru C
- Rao Madhumathi
- Rasheed Asif
- Rasmussen-Torvik Laura J
- Rathmann Wolfgang
- Rauramaa Rainer
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Redline Susan
- Reeve Jonathan
- Rehnberg Emil
- Reid David M
- Reid Ian R
- Reilly Muredach
- Reinmaa Eva
- Renstrom Frida
- Reppe Sjur
- Restrepo Nicole
- Rettig Rainer
- Riancho José A
- Ricceri Fulvio
- Rice John P
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- Rice Kenneth M
- Rice Treva K
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- Ridker Paul
- Ried Janina S
- Rigalleau Vincent
- Ring Susan M
- Ripatti Samuli
- Ritchie Marylyn
- Rivadeneira Fernando
- Robbins John
- Roberts Robert
- Robertson Neil
- Robino Antonietta
- Roman Tamara S
- Rose Lynda M
- Roseman Fenella
- Rosengren Annika
- Rosengård-Bärlund Milla
- Rosinger Silke
- Rosmalen Judith G M
- Rosse Stephanie
- Rossing Peter
- Rotimi Charles
- Rotter Jerome I
- Rousseau François
- Roussel Ronan
- Rubin Diana
- Rudan Igor
- Rudock Megan E
- Ruggiero Daniela
- Rumpf Moritz P
- Ruokonen Aimo
- Rybin Denis
- Räikkönen Katri
- Saaristo Timo E
- Sadlier Denise M
- Sala Cinzia
- Salako Tunde
- Saleheen Danish
- Salem Rany M
- Salo Perttu
- Salomaa Veikko
- Salumets Andres
- Samani Nilesh
- Sambrook Philip N
- Sandholm Niina
- Sandhu Manjinder S
- Sanghera Dharambir K
- Sanna Serena
- Saraheimo Markku
- Saramies Jouko
- Sarti Cinzia
- Sarzynski Mark A
- Sattar Naveed
- Savage David A
- Saxena Richa
- Schadt Eric
- Scharnagl Hubert
- Scherag André
- Schlessinger David
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholtens Salome
- Schork Nicholas J
- Schreiber Stefan
- Schumacher Fredrick
- Schunkert Heribert
- Schwartz Stephen M
- Schwarz Peter E H
- Schäfer Arne
- Scollen Serena
- Scott James
- Scott Laura J
- Scott Robert A
- Scuteri Angelo
- Seeley Janet
- Segrè Ayellet V
- Sehmi Joban S
- Seielstad Mark
- Sekowska Magdalena
- Semple Robert
- Sengupta Sebanti
- Sennblad Bengt
- Serafinceanu Cristian
- Service Susan K
- Seshadri Sudha
- Seufferlein Thomas
- Shah Sonia
- Shah Svati H
- Sham Pak Chung
- Sharma Pankaj
- Shaw-Hawkins Sue
- Sheu Wayne H-H
- Shi Gang
- Shin So-Youn
- Shlipak Michael G
- Shohet Ralph
- Shrine Nick R G
- Shriner Daniel
- Shuldiner Alan R
- Shungin Dmitry
- Sidore Carlo
- Siegbahn Agneta
- Siggeirsdottir Kristin
- Sigurdsson Gunnar
- Sijbrands Eric J G
- Silander Kaisa
- Sim Xueling
- Singleton Andrew
- Sinisalo Juha
- Siscovick David S
- Sitlani Colleen M
- Sivananthan Mohan
- Sjögren Marketa
- Skorpen Frank
- Slaets Joris P
- Slagboom P Eline
- Small Kerrin
- Small Kerrin S
- Smit Johannes H
- Smith Albert
- Smith Erin N
- Smith George Davey
- Smith Jennifer A
- Smith Nicholas L
- Snider Harold
- Snieder Harold
- Soininen Pasi
- Song Ci
- Song Kijoung
- Soranzo Nicole
- Sorice Rossella
- Soro-Paavonen Aino
- Sovio Ulla
- Spector Tim D
- Spector Timothy D
- Speliotes Elizabeth K
- Spencer Kylee
- Srinivasan Sathanur R
- St Pourcain Beate
- Stacey Simon N
- Staessen Jan A
- Stanèáková Alena
- Stančáková Alena
- Stark Klaus
- Starr John M
- Stathopoulou Maria G
- Stavarachi Monica
- Stefansson Kari
- Steinle Nanette I
- Steinthorsdottir Valgerdur
- Stewart Alexandre F R
- Stirrups Kathleen
- Stolk Lisette
- Stolk Ronald P
- Strachan David P
- Stracke Sylvia
- Stram Daniel
- Strauch Konstantin
- Strawbridge Rona J
- Streeten Elizabeth A
- Stringham Heather M
- Struchalin Maksim
- Stumvoll Michael
- Styrkarsdottir Unnur
- Sulem Patrick
- Sun Yan V
- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
- Syvänen Ann-Christine
- Sõber Siim
- Söderlund Jenny
- Tabara Yasuharu
- Tai E Shyong
- Taliun Daniel
- Talmud Philippa J
- Tammesoo Mar-Liis
- Tan Sian-Tsung
- Tanaka Toshiko
- Tang Nelson L S
- Tarnow Lise
- Taylor Andrew
- Taylor Kira
- Tayo Bamidele
- Tenesa Albert
- Terzic Janos
- Teslovich Tanya M
- Teumer Alexander
- Thelle Dag S
- Thompson John R
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
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- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
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- van der Harst Pim
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- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
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- van Nierop Peter
- van Oort Floor V A
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- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Feminist perspectives and the criminal justice curriculum
- Author
- Adler Freda
- Bowker Lee H.
- Bowles Gloria
- Campbell Anne
- Carlen Pat
- Carlen Pat
- Chesney-Lind Meda
- Culley Margo
- Davidson Sue
- Feinman Clarice
- Flowers Ronald Barri
- Garrison Carole
- Geselthorpe Loraine
- Goodstein Lynne
- Hall Roberta
- Heindensohn Frances
- Heindensohn Frances
- Howe Florence
- Johnson Sonia
- Kelly Gadol Joan
- Lowney Kathleen S.
- Lynne Goodstein
- McIntosh Peggy
- McIntosh Peggy
- Messerschmidt James
- Morash
- Morris Allison
- Naffine Ngaire
- Price Barbara Raffel
- Rafter Nicole Hahn
- Richey Mann Coramae
- Schmitz Betty
- Schneidewind Nancy
- Schuster Marilyn R.
- Schuster Marilyn R.
- Shrewbury C.M.
- Smart Carol
- Spanier Bonnie
- Stimpson Catharine
- Ward Kelly
- Warren Marguerite Q.
- Weisheit Ralph
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
The Most-Cited Scholars and Works in Women and Crime Publications
- Author
- Adler Freda
- Barbara Raffel Price
- Belknap Joanne
- Browne Angela
- Brownmiller Susan
- Chapman A. J.
- Chesney-Lind Meda
- Cindy Sheridan
- Cohn Ellen G.
- Cohn Ellen G.
- Cohn Ellen G.
- Cole Stephen
- Dob-ash Rebecca Emerson
- Ewing Charles Patrick
- Feinman Clarice
- Freedman Estelle B.
- Gelsthorpe Loraine
- Ghck Ruth M.
- Gilligan Carol
- Gottfredson Michael R.
- Heidensohn Frances M.
- Hirschi Travis
- Kanter Rosabeth Moss
- Leonard Eileen B.
- Maguire Kathleen
- Mann Coramae Richey
- Martin Susan Ehrlich
- Martin Susan Ehrlich
- Merlo Alida V.
- Merton Robert K.
- Morris Allison
- Moyer Imogene
- Muraskin Rosalyn
- Naffine Ngaire
- Nicole Hahn Rafter
- Pollak Otto
- Pollock-Byrne Joycelyn
- Richard A. Wright
- Russell Diana E. H.
- Smart Carol
- Smart Carol
- Stanko Elizabeth A.
- Walker Leonore E.
- Ward David A.
- Wolfgang Marvin E.
- Wright Richard A.
- Wright Richard A.
- Wright Richard A.
- Zimmer Lynn E.
- Publication venue
- 'The Haworth Press'
- Publication date
- Field of study
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
- Author
- Alan F. Wright
- Albert Hofman
- Ananth C. Viswanathan
- Andrea Richardson
- Andrew D. Paterson
- André G. Uitterlinden
- Angela Döring
- Barbara Klein
- Ben A. Oostra
- Bhalla
- Biino
- Bitel
- Brian Fleck
- Caroline C.W. Klaver
- Caroline Hayward
- Christian Gieger
- Claire L. Simpson
- Cornelia M. van Duijn
- Dirani
- Dirani
- Dwight Stambolian
- Elena Rochtchina
- Elizabeth G. Holliday
- Emily Y. Chew
- Fan
- Federico Murgia
- Fernando Rivadeneira
- Fogel
- Fotis Topouzis
- Gehman
- Gentle
- H.-Erich Wichmann
- Hammond
- Harry Campbell
- He
- Holden
- Hysi
- Igor Rudan
- Ip
- James F. Wilson
- Jerome I. Rotter
- Jie Jin Wang
- Jing Xie
- Joan E. Bailey-Wilson
- Johannes R. Vingerling
- John Attia
- Kang
- Kent
- Klein
- Konrad Oexle
- Krista Kazmierkiewicz
- Laura Portas
- Laurie
- Lee
- Lennart C. Karssen
- Leslie J. Raffel
- Li
- Li
- Lin
- Lyhne
- Marchini
- Maria Schache
- Mario Pirastu
- Martin
- Mary Frances Cotch
- Maurizio Fossarello
- Michael Inouye
- Morgan
- Najaf Amin
- Nakahata
- Nakanishi
- Nallasamy
- Ovcharenko
- Ovcharenko
- Ozren Polašek
- Patterson
- Paul J. Foster
- Paul Mitchell
- Paul N. Baird
- Peet
- Penha
- Peter McGuffin
- Pizzarello
- Price
- Purcell
- Robert Wojciechowski
- Rodney J. Scott
- Ronald Klein
- Rose
- S.M. Hosseini
- Sanna
- Saw
- Schippert
- Seang Mei Saw
- Shi
- Shi
- Smigielski
- Solouki
- Stothard
- Thomas Bettecken
- Thomas Meitinger
- Thomas-Chollier
- Tien Y. Wong
- Veerappan
- Verhoeven
- Veronique Vitart
- Virginie J.M. Verhoeven
- Voineagu
- Willer
- Wistow
- Wojciechowski
- Wojciechowski
- Xiaohui Li
- Xueling Sim
- Yanovitch
- Zhang
- Zoran Vatavuk
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2013
- Field of study
10.1093/hmg/ddt116Human Molecular Genetics22132754-2764HMGE
Different Ways of Conceptualizing Sex/Gender in Feminist Theory and their Implications for Criminology
- Author
- Andersen Margaret L.
- Anthias Floya
- Austin Regina
- Barrett Michele
- Beirne Piers
- Belkhir Jean
- Bell Derrick
- Bordo Susan
- Bordo Susan
- Brown Wendy
- Butler Judith
- Butler Judith
- Butler Judith
- Cain Maureen
- Cain Maureen
- Cain Maureen
- Cain Maureen
- Carlen Pat
- Carlen Pat
- Carlen Pat
- Carrington Kerry
- Carrington Kerry
- Cole Johnetta B.
- Collins Patricia Hill
- Collins Patricia Hill
- Combahee River Collective
- Connell R. W.
- Connell R. W.
- Daly Kathleen
- Daly Kathleen
- Daly Kathleen
- Daly Kathleen
- Daly Kathleen
- Daly Kathleen
- Davis Angela
- de Lauretis Teresa
- di Leonardo Micaela
- di Stefano Christine
- Fineman Martha
- Flax Jane
- Gallop Jane
- Gatens Moira
- Giddens Anthony
- Grosz Elizabeth
- Grosz Elizabeth
- Grosz Elizabeth
- Harding Sandra
- Harding Sandra
- Harding Sandra
- Hartsock Nancy
- Henry Stuart
- hooks bell
- Howe Adrian
- Howe Adrian
- Jaggar Alison
- Jaggar Alison
- Jefferson Tony
- Jordan June
- KATHLEEN DALY
- Katz Jonathan
- Lemert Charles C.
- Lorde Audre
- Lubiano Wahneema
- Lugones Maria C.
- Maher Lisa
- Marcus Sharon
- Martin Susan E.
- Messerschmidt James W.
- Moraga Cherrie
- Naffine Ngaire
- Nicholson Linda
- Norris Christopher
- Platt Anthony M.
- Pratt Minnie Bruce
- Price Barbara Raffel
- Radford Jill
- Rich Adrienne
- Ruiz Vicki L.
- Sargeant Lydia
- Schwartz Martin D.
- Scott Joan W.
- Seidman Steven
- Smart Carol
- Smart Carol
- Smart Carol
- Smith Dorothy
- Smith Dorothy E.
- Spivak Gayatri Chakravorty
- Stivers Camilla
- Thorne Barrie
- Wagner David G.
- Williams Patricia J.
- Worrall Anne
- Yeatman Anna
- Young Alison
- Young Alison
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair [editorial comment]
- Author
- Abecasis Gonçalo R.
- Albrecht Eva
- Alizadeh Behrooz Z.
- Altmaier Elisabeth
- Amin Najaf
- Andrulis Irene L.
- Anton-Culver Hoda
- Antoniou Antonis C.
- Arndt Volker
- Arnold Alice M.
- Barbieri Caterina
- Beckmann Matthias W.
- Beeghly-Fadiel Alicia
- Benitez Javier
- Bergmann Sven
- Bernstein Leslie
- Bielinski Suzette J.
- Blomqvist Carl
- Boerwinkle Eric
- Bogdanova Natalia V.
- Bojesen Stig E.
- Bolla Manjeet K.
- Boomsma Dorret I.
- Borresen-Dale Anne-Lise
- Boutin Thibaud S.
- Brauch Hiltrud
- Brenner Hermann
- Brody Jennifer A.
- Brüning Thomas
- Bulik-Sullivan Brendan
- Buring Julie E.
- Burwinkel Barbara
- Campbell Archie
- Campbell Harry
- Chang-Claude Jenny
- Chanock Stephen J.
- Chapman J. Ross
- Chasman Daniel I.
- Chenevix-Trench Georgia
- Ciullo Marina
- Corre Tanguy
- Couch Fergus J.
- Coviello Andrea D.
- Cox Angela
- Crisponi Laura
- Czene Kamila
- Darabi Hatef
- Day Felix R.
- De Vivo Immaculata
- Demerath Ellen W.
- Dennis Joe
- Devilee Peter
- dos-Santos-Silva Isabel
- Dunning Alison M.
- Dörk Thilo
- Easton Douglas F.
- Eicher John D.
- Elks Cathy E.
- Esko Tõnu
- Fasching Peter A.
- Faul Jessica D.
- Ferrucci Luigi
- Figueroa Jonine
- Finucane Hilary K.
- Flesch-Janys Dieter
- Franceschini Nora
- Franke Lude L.
- Gandin Ilaria
- Garcia Melissa E.
- García-Closas Montserrat
- Gasparini Paolo P.
- Gieger Christian
- Giles Graham G.
- Girotto Giorgia G.
- Goldberg Mark S.
- González-Neira Anna
- Goodarzi Mark O.
- Grove Megan L.
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Guénel Pascal
- Haiman Christopher A.
- Hall Per
- Hamann Ute
- Harris Tamara B.
- Hayward Caroline
- He Chunyan
- Henderson Brian E.
- Hocking Lynne J.
- Hofman Albert
- Homuth Georg
- Hooning Maartje J.
- Hopper John L.
- Hottenga Jouke-Jan
- Hu Frank B.
- Huang Jinyan
- Huffman Jennifer E.
- Humphreys Keith
- Hunter David J.
- Ida Chen Yii-Der
- Jakubowska Anna
- Johnson Andrew D.
- Jones Samuel E.
- Kabisch Maria
- Karasik David
- Kardia Sharon L. R.
- Keller Margaux F.
- Knight Julia A.
- Kolcic Ivana
- Kooperberg Charles
- Kosma Veli-Matti
- Kraft Peter
- Kriebel Jennifer
- Kristensen Vessela
- Lambrechts Diether
- Langenberg Claudia
- Li Jingmei
- Li Xin
- Lindström Sara
- Liu Yongmei
- Luan Jian’an
- Lubinski Jan
- Lunetta Kathryn L.
- Mangino Massimo
- Mannermaa Arto
- Manz Judith
- Margolin Sara
- Marten Jonathan
- Martin Nicholas G.
- Masciullo Corrado
- McArdle Patrick F.
- McKnight Barbara
- Meindl Alfons
- Metspalu Andres
- Michailidou Kyriaki
- Mihailov Evelin
- Milani Lili
- Milne Roger L.
- Montgomery Grant W.
- Morrison Alanna C.
- Murabito Joanne M.
- Murray Anna
- Mägi Reedik
- Müller-Nurasyid Martina
- Nalls Michael
- Neale Benjamin M.
- Nevanlinna Heli
- Neven Patrick
- Newman Anne B.
- Nordestgaard Børge G.
- Nutile Teresa
- Olson Janet E.
- Ong Ken K.
- Padmanabhan Sandosh
- Perry John R. B.
- Pervjakova Natalia
- Peterlongo Paolo
- Peters Ulrike
- Petersmann Astrid
- Peto Julian
- Pharoah Paul D. P.
- Pirastu Nicola N.
- Pirie Ailith
- Pistis Giorgio
- Polasek Ozren
- Porcu Eleonora
- Porteous David
- Price Alkes L.
- Psaty Bruce M.
- Pylkäs Katri
- Radice Paolo
- Raffel Leslie J.
- Reiner Alex P.
- Ridker Paul M.
- Rivadeneira Fernando
- Robino Antonietta
- Rose Lynda M.
- Rotter Jerome I.
- Rudan Igor
- Rudolph Anja
- Ruggiero Daniela
- Ruth Katherine S.
- Sala Cinzia F.
- Sanna Serena
- Sawyer Elinor J.
- Schick Ursula M.
- Schlessinger David
- Schmidt Frank
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Schoemaker Minouk J.
- Scott Robert A.
- Seynaeve Caroline M.
- Simard Jacques
- Smith Albert V.
- Smith Jennifer A.
- Sorice Rossella
- Southey Melissa C.
- Spector Tim D.
- Stefansson Kari
- Stolk Lisette
- Strauch Konstantin
- Stöckl Doris
- Sulem Patrick
- Swerdlow Anthony
- Tanaka Toshiko
- Taylor Kent D.
- Teumer Alexander
- Thompson Deborah J.
- Thorsteinsdottir Unnur
- Toland Amanda E.
- Tomlinson Ian
- Toniolo Daniela
- Traglia Michela
- Truong Thérèse
- Tryggvadottir Laufey
- Turner Stephen T.
- Uitterlinden André G.
- Ulivi Sheila
- van Duijn Cornelia M.
- Visser Jenny A.
- Vozzi Diego
- Vuckovic Dragana
- Völzke Henry
- Wang Qin
- Wareham Nicholas J.
- Weir David R.
- Wellons Melissa
- Willemsen Gonneke
- Wilson James F.
- Winqvist Robert
- Wolffenbuttel Bruce B. H. R.
- Wright Alan F.
- Yannoukakos Drakoulis
- Yao Jie
- Yerges-Armstrong Laura M.
- Zemunik Tatijana
- Zhao Wei
- Zheng Wei
- Zygmunt Marek
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/12/2015
- Field of study
ABSTRACT: Menopause timing has a major impact on infertility and risk of disease. Younger age at natural (nonsurgical) menopause (ANM) is associated with a higher risk of osteoporosis, cardiovascular disease, and type 2 diabetes and a lower risk of breast cancer. Late menopause is associated with a higher risk of breast cancer. It is well known that the age at which women go through menopause is partly determined by genes, but the underlying mechanisms are poorly understood. Genome-wide association studies have identified 18 common genetic variants associated with ANM. These variants explain less than 5% of the variation in ANM compared with the 21% explained by all common variants on genome-wide association study arrays.
This genome-wide association study was the collaborative effort of researchers from 177 institutions worldwide. The study was designed to investigate genetic variants associated with timing of menopause among a population of approximately 70,000 women of European ancestry. A dual strategy was used to identify both common and, for the first time, low-frequency coding variants associated with ANM. The causal relationship between ANM and breast cancer was investigated using a Mendelian randomization approach.
Combined analysis identified 1208 single-nucleotide polymorphisms (SNPs) of a total of approximately 2.6 million that reached the genome-wide significance threshold for association with ANM. Forty-four regions with common variants were identified; among these 44 loci were 2 rare low-frequency missense alleles of large effect. A majority of ANM SNPs were enriched in DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal relationship between delayed ANM and breast cancer risk; there was approximately 6% increase in risk per year; P = 3 × 10-14); increased risk with delayed menopause appeared to be mediated primarily by prolonged sex hormone exposure in a woman’s lifetime, not DDR mechanisms.
This is the first study to confirm the link between early and late menopause and breast cancer risk using genetic information. Age at natural menopause genetic variants influence breast cancer risk primarily through variation in menopause timing. Although carrying higher numbers of ANM-increasing variants and enrichment in DDR genes are associated with a modest increase in breast cancer risk, the major mechanism for increased risk appears to be prolonged estrogen and/or progesterone exposure due to delayed menopause
Feminism and criminology
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- Abel Elizabeth
- Ackoff Linda
- Adler Freda
- Alexander Priscilla
- Allen Hilary
- Andersen Margaret L.
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Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
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- A Fogli
- A Trifunovic
- Ailith Pirie
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- Alanna C Morrison
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- Alfons Meindl
- Alice M Arnold
- Alicia Beeghly-Fadiel
- Alison M Dunning
- Alkes L Price
- Amanda E Toland
- AN Monteiro
- Andrea D Coviello
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- Angela Cox
- Anja Rudolph
- Anna González-Neira
- Anna Jakubowska
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- Anne-Lise Borresen-Dale
- Anthony Swerdlow
- Antonietta Robino
- Antonis C Antoniou
- Archie Campbell
- Arto Mannermaa
- Astrid Petersmann
- AV Segrè
- B Howie
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- Barbara Burwinkel
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- Benjamin M Neale
- Brendan Bulik-Sullivan
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- Carl Blomqvist
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- Qin Wang
- R Andersson
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- Robert Winqvist
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- 'Springer Science and Business Media LLC'
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- 01/01/2015
- Field of study
Copyright © 2015, Rights Managed by Nature Publishing GroupThis is the author's version of an article subsequently published in definitive form at: Nature Genetics (2015) doi:10.1038/ng.3412See supplementary documents for full affiliations and acknowledgmentsMenopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms
Genetic studies of body mass index yield new insights for obesity biology
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- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p