5,394 research outputs found
Investigation of the current status of anticoagulant resistance in UK Norway rats by VKORC1 genotyping
Clarke, D.J., Prescott, C.V
Measurement of the parity violating 6S-7S transition amplitude in cesium achieved within 2 \times 10^{-13} atomic-unit accuracy by stimulated-emission detection
We exploit the process of asymmetry amplification by stimulated emission
which provides an original method for parity violation (PV) measurements in a
highly forbidden atomic transition. The method involves measurements of a
chiral, transient, optical gain of a cesium vapor on the 7S-6P_{3/2}
transition, probed after it is excited by an intense, linearly polarized,
collinear laser, tuned to resonance for one hyperfine line of the forbidden
6S-7S transition in a longitudinal electric field. We report here a 3.5 fold
increase, of the one-second-measurement sensitivity, and subsequent reduction
by a factor of 3.5 of the statistical accuracy compared with our previous
result [J. Gu\'ena et al., Phys. Rev. Lett. 90, 143001 (2003)]. Decisive
improvements to the set-up include an increased repetition rate, better
extinction of the probe beam at the end of the probe pulse and, for the first
time to our knowledge, the following: a polarization-tilt magnifier,
quasi-suppression of beam reflections at the cell windows, and a Cs cell with
electrically conductive windows. We also present real-time tests of systematic
effects, consistency checks on the data, as well as a 1% accurate measurement
of the electric field seen by the atoms, from atomic signals. PV measurements
performed in seven different vapor cells agree within the statistical error.
Our present result is compatible with the more precise Boulder result within
our present relative statistical accuracy of 2.6%, corresponding to a 2 \times
10^{-13} atomic-unit uncertainty in E_1^{pv}. Theoretical motivations for
further measurements are emphasized and we give a brief overview of a recent
proposal that would allow the uncertainty to be reduced to the 0.1% level by
creating conditions where asymmetry amplification is much greater.Comment: Article 21 pages, 6 figures, 3 tables Typos, addition of few comments
and little more data (1 week) leading to a slight reduction of the error bar
Accepted for publication in Phys.Rev.
Cross-country differences in unemployment : fiscal policy, unions, and household preferences in general equilibrium
We develop a five period overlapping generations model with individuals who differ by ability and with an imperfect labour market (union wage setting) for the individuals of lower ability. The model explains human capital formation, hours
worked and unemployment within one coherent framework. Its predictions match the differences in the unemployment rate across 12 OECD countries remarkably well. A Shapley decomposition of these differences reveals an almost equal role
for fiscal policy variables and union preferences. As to fiscal policy, differences in unemployment benefits play a much more important role than tax differences. Differences in households’ taste for leisure are unimportant
Atomic Hydrogen Cleaning of Polarized GaAs Photocathodes
Atomic hydrogen cleaning followed by heat cleaning at 450C was used
to prepare negative-electron-affinity GaAs photocathodes. When hydrogen ions
were eliminated, quantum efficiencies of 15% were obtained for bulk GaAs
cathodes, higher than the results obtained using conventional 600C heat
cleaning. The low-temperature cleaning technique was successfully applied to
thin, strained GaAs cathodes used for producing highly polarized electrons. No
depolarization was observed even when the optimum cleaning time of about 30
seconds was extended by a factor of 100
Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device
Neurobehavioral data from intact, decerebrate, and neonatal rats, suggests that the reticular formation provides
a brainstem substrate for action selection in the vertebrate central nervous system. In this article, Kilmer,
McCulloch and Blum’s (1969, 1997) landmark reticular formation model is described and re-evaluated, both in
simulation and, for the first time, as a mobile robot controller. Particular model configurations are found to
provide effective action selection mechanisms in a robot survival task using either simulated or physical robots.
The model’s competence is dependent on the organization of afferents from model sensory systems, and a genetic
algorithm search identified a class of afferent configurations which have long survival times. The results support
our proposal that the reticular formation evolved to provide effective arbitration between innate behaviors
and, with the forebrain basal ganglia, may constitute the integrative, ’centrencephalic’ core of vertebrate brain
architecture. Additionally, the results demonstrate that the Kilmer et al. model provides an alternative form of
robot controller to those usually considered in the adaptive behavior literature
The Buckland Park air shower array
The new Buckland Park Air Shower Array has been producing analyzed shower data since July 1984. The array is described and some preliminary performance figures are presented
Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Children Less Than 5 Years of Age.
BACKGROUND:Hizentra® (IGSC 20%) is a 20% liquid IgG product approved for subcutaneous administration in adults and children 2 years of age and older who have primary immunodeficiency disease (PIDD). There is limited information about the use of IGSC 20 % in very young children including those less than 5 years of age. METHODS:A retrospective chart review involved 88 PIDD infants and children less than 5 years of age who received Hizentra®. RESULTS:The mean age at the start of Hizentra® was 34 months (range 2 to 59 months). IGSC 20 % was administered weekly to 86 infants (two additional infants received twice weekly and three times weekly infusions, respectively) and included an average of 63 infusions (range 6-182) for an observation period up to 45.5 months. Infusion by manual delivery occurred in 15 patients. The mean dose was 674 mg/kg/4 weeks. The mean IgG level was 942 mg/dL while on IGSC 20 %, compared to a mean trough IgG level of 794 mg/dL (p < 0.0001) during intravenous or subcutaneous IgG administration prior to IGSC 20 %. Average infusion time was 47 (range 5-120) minutes, and the median number of infusion sites was 2 (range 1-4). Local reactions were mostly mild and observed in 36/88 (41%) children. No serious adverse events were reported. A significant increase in weight percentile (7 % ± 19.2, p = 0.0012) among subjects was observed during IGSC 20% administration. The rate of serious bacterial infections was 0.067 per patient-year while receiving IGSC 20%, similar to previously reported efficacy studies. CONCLUSIONS:Hizentra® is effective in preventing infections, and is well tolerated in children less than age 5 years
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