122 research outputs found
Microwave cavity light shining through a wall optimization and experiment
It has been proposed that microwave cavities can be used in a photon
regeneration experiment to search for hidden sector photons. Using two isolated
cavities, the presence of hidden sector photons could be inferred from a 'light
shining through a wall' phenomenon. The sensitivity of the experiment has
strong a dependence on the geometric construction and electromagnetic mode
properties of the two cavities. In this paper we perform an in depth
investigation to determine the optimal setup for such an experiment. We also
describe the results of our first microwave cavity experiment to search for
hidden sector photons. The experiment consisted of two cylindrical copper
cavities stacked axially inside a single vacuum chamber. At a hidden sector
photon mass of 37.78 micro eV we place an upper limit on the kinetic mixing
parameter chi = 2.9 * 10^(-5). Whilst this result lies within already
established limits our experiment validates the microwave cavity `light shining
through a wall' concept. We also show that the experiment has great scope for
improvement, potentially able to reduce the current upper limit on the mixing
parameter chi by several orders of magnitude.Comment: To be published in PR
Microwave cavity hidden sector photon threshold crossing
Hidden sector photons are a weakly interacting slim particle arising from an
additional U(1) gauge symmetry predicted by many standard model extensions. We
present and demonstrate a new experimental method using a single microwave
cavity to search for hidden sector photons. Only photons with a great enough
energy are able to oscillate into hidden sector photons of a particular mass.
If our cavity is driven on resonance and tuned over the corresponding threshold
frequency, there is an observable drop in the circulating power signifying the
creation of hidden sector photons. This approach avoids the problems of
microwave leakage and frequency matching inherent in photon regeneration
techniques
A bottom-up fabrication method for the production of visible light active photonic crystals
A method which combines polymer particle assembly, chemical infiltration and etching with an aerosol assisted deposition process is described for the fabrication of 3D inverse opal (10) structures with sub-micron periodicity and precision. This procedure not only overcomes limitations associated with slow, expensive micro-fabrication methods but also permits the tuning of refractive index contrast via the direct incorporation of photonically-active, preformed, tailored silicon nanostructures. It is demonstrated that this approach can be used to modify the photonic band gap (PBG) by effectively depositing/patterning optically active silicon nanocrystals (ncSi) onto the pore walls of a 3D inverse opal structure. This simple, yet effective method for preparing functional complex 3D structures has the potential to be used generically to fabricate a variety of functional porous 3D structures that could find application not only in new or improved photonic crystal (PC) devices but also in areas such as catalysis, separation, fuel cells technology, microelectronics and optoelectronics
Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples
Background
Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifestyle factors can affect STL and associated clinical outcomes.
Objectives
The purpose of this manuscript is to investigate any association between STL with lifestyle factors, semen parameters and clinical outcomes.
Materials and methods
Sperm telomere length was measured using real‐time PCR in normozoospermic male partners (n = 66) of couples undergoing ART treatment. Each participant also completed a detailed questionnaire about general lifestyle. Linear regression univariate analysis and ANCOVA were performed to respectively determine correlations between STL and study parameters or identify statistically significant differences in STL while controlling for age, BMI and other factors.
Results
Using a linear regression model, STL is positively correlated with in vitro fertilization success (n = 65, r = 0.37, P = .004) but not with embryo cleavage rates and post‐implantation clinical outcomes including gestational age‐adjusted birth weight. No associations were observed between STL and sperm count, concentration or progressive motility. We further found that STL did not associate age, BMI, health or lifestyle factors.
Discussion
In somatic cells, the rate of telomere shortening is influenced by a number of lifestyle factors such as smoking, diet and occupation. However, little is known about how lifestyle factors affect STL and subsequently reproductive outcome. Out data suggest that STL might have an important role mechanistically for fertilization rate regardless of sperm parameters and lifestyle factors.
Conclusion
The results of this study demonstrate that STL is associated with in vitro fertilization rates, but not with semen parameters nor lifestyle factors. Further investigations are warranted to identify the potential variation of STL overtime to clarify its significance as a potential biomarker in ART
Effect of surface and defect chemistry on the photo-catalytic properties of intentionally defect-rich ZnO nanorod arrays
Due to the abundance of intrinsic defects in zinc oxide (ZnO) the material properties are often governed by same. Knowledge of the defect chemistry has proven to be highly important, especially in terms of the photo-catalytic degradation of pollutants. Given the fact that defect-free materials or structures exhibiting only one type of defect are extremely difficult to produce, it is necessary to evaluate what influence various defects may have when present together in the material. In this study, intentionally defect-rich ZnO nanorod (NR) arrays are grown using a simple low-temperature solution-based growth technique. Upon changing the defect chemistry using rapid thermal annealing (RTA) the material properties are carefully assessed and correlated to the resulting photo-catalytic properties. Special focus is put on the investigation of these properties for samples showing strong orange photoluminescence (PL). It is shown that intense orange emitting NR arrays exhibit improved dye-degradation rates under UV-light irradiation. Furthermore strong dye-adsorption has been observed for some samples. This behavior is found to stem from a graphitic surface structure (e.g. shell) formed during RTA in vacuum. Since orange-luminescent samples also exhibit an enhancement of the dye-adsorption a possible interplay and synergy of these two defects is elucidated. Additionally, evidence is presented suggesting that in annealed ZnO NRs structural defects may be responsible for the often observed PL emission at 3.31 eV. However, a clear correlation with the photo-catalytic properties could not be established for these defects. Building on the specific findings presented here, this study also presents some more general guidelines which it is suggested, should be employed when assessing the photo-catalytic properties of defect-rich ZnO
Back-gated Nb-doped MoS2 junctionless field-effect-transistors
Electrical measurements were carried out to measure the performance and evaluate the characteristics of MoS2 flakes doped with Niobium (Nb). The flakes were obtained by mechanical exfoliation and transferred onto 85 nm thick SiO2 oxide and a highly doped Si handle wafer. Ti/Au (5/45 nm) deposited on top of the flake allowed the realization of a back-gate structure, which was analyzed structurally through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). To best of our knowledge this is the first cross-sectional TEM study of exfoliated Nb-doped MoS2 flakes. In fact to date TEM of transition-metal-dichalcogenide flakes is extremely rare in the literature, considering the recent body of work. The devices were then electrically characterized by temperature dependent Ids versus Vds and Ids versus Vbg curves. The temperature dependency of the device shows a semiconductor behavior and, the doping effect by Nb atoms introduces acceptors in the structure, with a p-type concentration 4.3 × 1019 cm−3 measured by Hall effect. The p-type doping is confirmed by all the electrical measurements, making the structure a junctionless transistor. In addition, other parameters regarding the contact resistance between the top metal and MoS2 are extracted thanks to a simple Transfer Length Method (TLM) structure, showing a promising contact resistivity of 1.05 × 10−7 Ω/cm2 and a sheet resistance of 2.36 × 102 Ω/sq
One or two doses of live varicella virus-containing vaccines: Efficacy, persistence of immune responses, and safety six years after administration in healthy children during their second year of life
Abstract Background This phase III B follow-up of an initial multicenter study (NCT00226499) will evaluate the ten-year efficacy of two doses of the combined measles-mumps-rubella-varicella vaccine (MMRV) and one dose of the live attenuated varicella vaccine (V) versus a measles-mumps-rubella control group (MMR) for the prevention of clinical varicella disease. Here we present efficacy results for six years post-vaccination. Methods In phase A of the study, healthy children aged 12–22 months from ten European countries were randomized (3:3:1) and received either two doses of MMRV, or one dose of combined MMR and one dose of monovalent varicella vaccine (MMR+V), or two doses of the MMR vaccine (control), 42 days apart. Vaccine efficacy against all and against moderate or severe varicella (confirmed by detection of viral DNA or epidemiological link) was assessed from six weeks up to six years post-dose 2 for the MMRV and MMR+V groups, and was calculated with 95% confidence intervals (CI). The severity of varicella was calculated using the modified Vazquez scale (mild ≤ 7; moderately severe = 8–15; severe ≥ 16). Herpes zoster cases were also recorded. Results 5289 children (MMRV = 2279, mean age = 14.2, standard deviation [SD] = 2.5; MMR+V = 2266, mean age = 14.2, SD = 2.4; MMR = 744, mean age = 14.2, SD = 2.5 months) were included in the efficacy cohort. 815 varicella cases were confirmed. Efficacy of two doses of MMRV against all and against moderate or severe varicella was 95.0% (95% CI: 93.6–96.2) and 99.0% (95% CI: 97.7–99.6), respectively. Efficacy of one dose of varicella vaccine against all and against moderate or severe varicella was 67.0% (95% CI: 61.8–71.4) and 90.3% (95% CI: 86.9–92.8), respectively. There were four confirmed herpes zoster cases (MMR+V = 2, MMR = 2), all were mild and three tested positive for the wild-type virus. Conclusions Two doses of the MMRV vaccine and one dose of the varicella vaccine remain efficacious through six years post-vaccination
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